WDR6_HUMAN - dbPTM
WDR6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDR6_HUMAN
UniProt AC Q9NNW5
Protein Name WD repeat-containing protein 6
Gene Name WDR6
Organism Homo sapiens (Human).
Sequence Length 1121
Subcellular Localization Cytoplasm . Colocalizes in the cytoplasm with STK11/LKB1.
Protein Description Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy..
Protein Sequence MDALEDYVWPRATSELILLPVTGLECVGDRLLAGEGPDVLVYSLDFGGHLRMIKRVQNLLGHYLIHGFRVRPEPNGDLDLEAMVAVFGSKGLRVVKISWGQGHFWELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWEQLLEDKHFQSYCLLEAAPGPEGFGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGYEELLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVLLFPSRPGLLKDPGVGGKARAGAGAPVVGSGSSGGGNAFTGLGPVSTLPSLHGKQGVTSVTCHGGYVYTTGRDGAYYQLFVRDGQLQPVLRQKSCRGMNWLAGLRIVPDGSMVILGFHANEFVVWNPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCTRPHVILREGLHGREITCVKRVGTITLGPEYGVPSFMQPDDLEPGSEGPDLTDIVITCSEDTTVCVLALPTTTGSAHALTAVCNHISSVRAVAVWGIGTPGGPQDPQPGLTAHVVSAGGRAEMHCFSIMVTPDPSTPSRLACHVMHLSSHRLDEYWDRQRNRHRMVKVDPETRYMSLAVCELDQPGLGPLVAAACSDGAVRLFLLQDSGRILQLLAETFHHKRCVLKVHSFTHEAPNQRRRLLLCSAATDGSLAFWDLTTMLDHDSTVLEPPVDPGLPYRLGTPSLTLQAHSCGINSLHTLPTREGHHLVASGSEDGSLHVFVLAVEMLQLEEAVGEAGLVPQLRVLEEYSVPCAHAAHVTGLKILSPSIMVSASIDQRLTFWRLGHGEPTFMNSTVFHVPDVADMDCWPVSPEFGHRCALGGQGLEVYNWYD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDALEDYV
-------CCHHHHCC		32.0722223895
7Phosphorylation-MDALEDYVWPRATS
-CCHHHHCCCCCCCC		8.6123663014
90UbiquitinationMVAVFGSKGLRVVKI
HEEHHHCCCEEEEEE		63.44-
120UbiquitinationWNMSDWIWDARWLEG
CCHHHHHHHHHHHHC		6.75-
237UbiquitinationDRSVRIWKVGDLRVP
CCCEEEEEECCEECC		33.6921890473
267UbiquitinationRVWQVKLLENYLISA
HHHHHHHHHHHHHHC		3.12-
267UbiquitinationRVWQVKLLENYLISA
HHHHHHHHHHHHHHC		3.1221890473
343UbiquitinationGVSALCFKSRSRPGT
CEEEEEECCCCCCCC		43.92-
352UbiquitinationRSRPGTLKAVTLAGS
CCCCCCEEEEEECCC		40.42-
373UbiquitinationTDTGALYLYDVEVKC
ECCCCEEEEEEEHHH		2.83-
382UbiquitinationDVEVKCWEQLLEDKH
EEEHHHHHHHHCCCC		40.60-
418UbiquitinationANGEGRVKVVPINTP
ECCCCCEEEEECCCC		35.8321890473
437UbiquitinationDQTLFPGKVHSLSWA
CCCCCCCCHHHHHHH		36.6921890473
448PhosphorylationLSWALRGYEELLLLA
HHHHHHCHHHHHHHH		10.37-
448UbiquitinationLSWALRGYEELLLLA
HHHHHHCHHHHHHHH		10.37-
467UbiquitinationGVVACLEISAAPSGK
CEEEEEEEEECCCCC		1.8821890473
467UbiquitinationGVVACLEISAAPSGK
CEEEEEEEEECCCCC		1.88-
490UbiquitinationRYLLPPSKQRWHTCS
HHCCCCHHHCCEECC		50.0521890473
514PhosphorylationVCGDRRGSVLLFPSR
EECCCCCCEEEECCC		14.0522617229
520UbiquitinationGSVLLFPSRPGLLKD
CCEEEECCCCCCCCC		43.7121890473
520UbiquitinationGSVLLFPSRPGLLKD
CCEEEECCCCCCCCC		43.71-
526UbiquitinationPSRPGLLKDPGVGGK
CCCCCCCCCCCCCCC		67.9121890473
544PhosphorylationGAGAPVVGSGSSGGG
CCCCCEECCCCCCCC		26.9027251275
545PhosphorylationAGAPVVGSGSSGGGN
CCCCEECCCCCCCCC		24.7222496350
547PhosphorylationAPVVGSGSSGGGNAF
CCEECCCCCCCCCCC		27.7522496350
548PhosphorylationPVVGSGSSGGGNAFT
CEECCCCCCCCCCCC		45.0129978859
555PhosphorylationSGGGNAFTGLGPVST
CCCCCCCCCCCCCCC		29.1429978859
556UbiquitinationGGGNAFTGLGPVSTL
CCCCCCCCCCCCCCC		23.37-
556UbiquitinationGGGNAFTGLGPVSTL
CCCCCCCCCCCCCCC		23.3721890473
561PhosphorylationFTGLGPVSTLPSLHG
CCCCCCCCCCCCCCC		27.6224667141
562PhosphorylationTGLGPVSTLPSLHGK
CCCCCCCCCCCCCCC		42.8124667141
563UbiquitinationGLGPVSTLPSLHGKQ
CCCCCCCCCCCCCCC		1.80-
565PhosphorylationGPVSTLPSLHGKQGV
CCCCCCCCCCCCCCE		35.7924719451
578PhosphorylationGVTSVTCHGGYVYTT
CEEEEEEECCEEEEC		24.29-
591PhosphorylationTTGRDGAYYQLFVRD
ECCCCCCEEEEEEEC		9.4028152594
592PhosphorylationTGRDGAYYQLFVRDG
CCCCCCEEEEEEECC		9.7528152594
599UbiquitinationYQLFVRDGQLQPVLR
EEEEEECCCCCHHCC		21.38-
622PhosphorylationWLAGLRIVPDGSMVI
CCCCEEECCCCCEEE		2.60-
647AcetylationWNPRSHEKLHIVNCG
ECCCCCCCEEEEECC		39.6823749302
647UbiquitinationWNPRSHEKLHIVNCG
ECCCCCCCEEEEECC		39.68-
677AcetylationAFAYLKDGDVMLYRA
HHHHCCCCCEEEEEE		28.02-
677UbiquitinationAFAYLKDGDVMLYRA
HHHHCCCCCEEEEEE		28.02-
708UbiquitinationGREITCVKRVGTITL
CCEEEEEEEEEEEEE		43.44-
738UbiquitinationEPGSEGPDLTDIVIT
CCCCCCCCCCCEEEE		73.40-
775PhosphorylationTAVCNHISSVRAVAV
HHHHHHHHCCCEEEE		18.4124719451
855UbiquitinationRNRHRMVKVDPETRY
HHCCCCEECCHHHHC		31.4221890473
885UbiquitinationLVAAACSDGAVRLFL
HHHHHCCCCCEEEEE		49.29-
896PhosphorylationRLFLLQDSGRILQLL
EEEEECCHHHHHHHH		19.6021712546
910UbiquitinationLAETFHHKRCVLKVH
HHHHHCCCCEEEEEE		38.63-
915UbiquitinationHHKRCVLKVHSFTHE
CCCCEEEEEEECCCC		19.94-
926PhosphorylationFTHEAPNQRRRLLLC
CCCCCCCHHHEEEEH		38.92-
940UbiquitinationCSAATDGSLAFWDLT
HHHCCCCCEEEEECC		21.23-
945UbiquitinationDGSLAFWDLTTMLDH
CCCEEEEECCCCCCC		27.90-
991PhosphorylationNSLHTLPTREGHHLV
CCCCCCCCCCCCEEE		44.45-
1052UbiquitinationAAHVTGLKILSPSIM
HHHHCCCEEECCEEE		42.84-
1082UbiquitinationHGEPTFMNSTVFHVP
CCCCCCCCCEEEECC		30.27-
1100PhosphorylationDMDCWPVSPEFGHRC
CCCCEECCCCCCCCC		18.03-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDR6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDR6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDR6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BORG4_HUMANCDC42EP4physical
16189514
G2E3_HUMANG2E3physical
16189514
PAPS2_HUMANPAPSS2physical
28514442
IGJ_HUMANIGJphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDR6_HUMAN

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Related Literatures of Post-Translational Modification

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