G2E3_HUMAN - dbPTM
G2E3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID G2E3_HUMAN
UniProt AC Q7L622
Protein Name G2/M phase-specific E3 ubiquitin-protein ligase
Gene Name G2E3
Organism Homo sapiens (Human).
Sequence Length 706
Subcellular Localization Nucleus, nucleolus . Cytoplasm . Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage.
Protein Description E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death..
Protein Sequence MNESKPGDSQNLACVFCRKHDDCPNKYGEKKTKEKWNLTVHYYCLLMSSGIWQRGKEEEGVYGFLIEDIRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSYHFPCGLQRECIFQFTGNFASFCWDHRPVQIITSNNYRESLPCTICLEFIEPIPSYNILRSPCCKNAWFHRDCLQVQAINAGVFFFRCTICNNSDIFQKEMLRMGIHIPEKDASWELEENAYQELLQHYERCDVRRCRCKEGRDYNAPDSKWEIKRCQCCGSSGTHLACSSLRSWEQNWECLECRGIIYNSGEFQKAKKHVLPNSNNVGITDCLLEESSPKLPRQSPGSQSKDLLRQGSKFRRNVSTLLIELGFQIKKKTKRLYINKANIWNSALDAFRNRNFNPSYAIEVAYVIENDNFGSEHPGSKQEFLSLLMQHLENSSLFEGSLSKNLSLNSQALKENLYYEAGKMLAISLVHGGPSPGFFSKTLFNCLVYGPENTQPILDDVSDFDVAQIIIRINTATTVADLKSIINECYNYLELIGCLRLITTLSDKYMLVKDILGYHVIQRVHTPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSELFTVHTLPDVKALGFWNSYLQAVEDGKSTTTMEDILIFATGCSSIPPAGFKPTPSIECLHVDFPVGNKCNNCLAIPITNTYKEFQENMDFTIRNTLRLEKEESSHYIGH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19UbiquitinationLACVFCRKHDDCPNK
EEEEEEECCCCCCCC		53.20-
31AcetylationPNKYGEKKTKEKWNL
CCCCCCCCCHHHHHE		61.6019815605
42PhosphorylationKWNLTVHYYCLLMSS
HHHEEHHHHHHHHHC		7.49-
86UbiquitinationLKCCVCKKNGASIGC
CEEEEECCCCCEEEE		56.33-
90PhosphorylationVCKKNGASIGCVAPR
EECCCCCEEEEECCC		22.4026270265
101PhosphorylationVAPRCKRSYHFPCGL
ECCCCCCCCCCCCCC		14.4124719451
166UbiquitinationILRSPCCKNAWFHRD
CCCCCCCCCCCCCCC		57.31-
200UbiquitinationNNSDIFQKEMLRMGI
CCCHHHHHHHHHCCC		34.05-
252UbiquitinationDYNAPDSKWEIKRCQ
CCCCCCCCCEEEECC		57.11-
290PhosphorylationLECRGIIYNSGEFQK
HCCCEEEECCCHHHH		11.0129496907
292PhosphorylationCRGIIYNSGEFQKAK
CCEEEECCCHHHHHH		23.8025159151
297UbiquitinationYNSGEFQKAKKHVLP
ECCCHHHHHHHHCCC		68.45-
300UbiquitinationGEFQKAKKHVLPNSN
CHHHHHHHHCCCCCC		43.75-
312PhosphorylationNSNNVGITDCLLEES
CCCCCCHHHHHHHCC		18.0923898821
319PhosphorylationTDCLLEESSPKLPRQ
HHHHHHCCCCCCCCC		42.4325159151
320PhosphorylationDCLLEESSPKLPRQS
HHHHHCCCCCCCCCC		29.3625159151
322UbiquitinationLLEESSPKLPRQSPG
HHHCCCCCCCCCCCC		73.41-
327PhosphorylationSPKLPRQSPGSQSKD
CCCCCCCCCCHHHHH		32.2925159151
330PhosphorylationLPRQSPGSQSKDLLR
CCCCCCCHHHHHHHH		34.3628102081
332PhosphorylationRQSPGSQSKDLLRQG
CCCCCHHHHHHHHHH		29.8128102081
333UbiquitinationQSPGSQSKDLLRQGS
CCCCHHHHHHHHHHH		44.77-
347PhosphorylationSKFRRNVSTLLIELG
HHHHHHHHHHHHHHC		19.5222210691
348PhosphorylationKFRRNVSTLLIELGF
HHHHHHHHHHHHHCC		22.6922210691
435PhosphorylationGSLSKNLSLNSQALK
CCCCCCCCCCCHHHH		34.5926270265
438PhosphorylationSKNLSLNSQALKENL
CCCCCCCCHHHHHCH		23.3226270265
442UbiquitinationSLNSQALKENLYYEA
CCCCHHHHHCHHHHH		47.8021890473
571UbiquitinationKTLGVLEKIQAYPEA
HHHHHHHHHHHCCHH		35.64-
586UbiquitinationFCSILCHKPESLSAK
HHHHHCCCCHHHHHH		49.86-
688PhosphorylationFQENMDFTIRNTLRL
HHHHCCCCHHHCEEE		18.1124719451
697UbiquitinationRNTLRLEKEESSHYI
HHCEEECCCCCCCCC		71.96-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of G2E3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of G2E3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of G2E3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CYTSA_HUMANSPECC1Lphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of G2E3_HUMAN

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Related Literatures of Post-Translational Modification

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