dbPTM

PKHA5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKHA5_HUMAN
UniProt AC	Q9HAU0
Protein Name	Pleckstrin homology domain-containing family A member 5
Gene Name	PLEKHA5
Organism	Homo sapiens (Human).
Sequence Length	1116
Subcellular Localization	Cytoplasm .
Protein Description
Protein Sequence	MAADLNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRPESICSVTPSTHDKTLGPGAEEKRRSMRDDTMWQLYEWQQRQFYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSPQRTYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEGPDYRLYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSASPVPSTQPQLTEGSHFMCV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAADLNLEW ------CCCCCCCEE	22.46	22223895
11	Phosphorylation	DLNLEWISLPRSWTY CCCCEEEECCCCEEE	33.13	24719451
22	Methylation	SWTYGITRGGRVFFI CEEEEECCCCEEEEE	43.58	115487831
55	Phosphorylation	VTGHRRQSTDLPTGW EECCCCCCCCCCCCC	23.29	30266825
56	Phosphorylation	TGHRRQSTDLPTGWE ECCCCCCCCCCCCCE	32.96	30266825
56 (in isoform 6)	Phosphorylation	-	32.96	27251275
60	Phosphorylation	RQSTDLPTGWEEAYT CCCCCCCCCCEEEEE	63.32	22199227
66	Phosphorylation	PTGWEEAYTFEGARY CCCCEEEEEECCCEE	18.42	23927012
67	Phosphorylation	TGWEEAYTFEGARYY CCCEEEEEECCCEEE	23.43	23927012
111	Phosphorylation	QTVATMTSEEKKERP CEEEECCCHHHHCCC	32.70	21712546
120	Phosphorylation	EKKERPISMINEASN HHHCCCCCCHHHHHC	19.12	21945579
120 (in isoform 6)	Phosphorylation	-	19.12	27251275
126	Phosphorylation	ISMINEASNYNVTSD CCCHHHHHCCCCCCC	33.40	21945579
128	Phosphorylation	MINEASNYNVTSDYA CHHHHHCCCCCCCCE	14.44	21945579
131	Phosphorylation	EASNYNVTSDYAVHP HHHCCCCCCCCEECC	16.55	21945579
132	Phosphorylation	ASNYNVTSDYAVHPM HHCCCCCCCCEECCC	25.09	21945579
134	Phosphorylation	NYNVTSDYAVHPMSP CCCCCCCCEECCCCC	15.41	21945579
140	Phosphorylation	DYAVHPMSPVGRTSR CCEECCCCCCCCCCC	22.38	21945579
140 (in isoform 6)	Phosphorylation	-	22.38	27251275
145	Phosphorylation	PMSPVGRTSRASKKV CCCCCCCCCCCHHHH	19.35	30387612
159	Phosphorylation	VHNFGKRSNSIKRNP HHCCCCCCCCCCCCC	38.11	27251789
159 (in isoform 6)	Phosphorylation	-	38.11	27251275
161	Phosphorylation	NFGKRSNSIKRNPNA CCCCCCCCCCCCCCC	30.63	23927012
245	Phosphorylation	AAHPNMRTYYFCTDT CCCCCCEEEEEECCC	16.29	29496907
247	Phosphorylation	HPNMRTYYFCTDTGK CCCCEEEEEECCCCH	7.49	29496907
275	Ubiquitination	LVQTEPVKRVDKITS HHCCCCCCCHHHCCC	58.37	-
279	Ubiquitination	EPVKRVDKITSENAP CCCCCHHHCCCCCCC	45.05	-
301	Sumoylation	PNHRVLIKPEIQNNQ CCCEEEECHHHHCCC	32.22	-
301	Sumoylation	PNHRVLIKPEIQNNQ CCCEEEECHHHHCCC	32.22	28112733
326	Ubiquitination	KKALEAEKYGFQKDG HHHHHHHHHCCCCCC	58.69	-
327	Phosphorylation	KALEAEKYGFQKDGQ HHHHHHHHCCCCCCC	18.06	28152594
343	Phosphorylation	RPLTKINSVKLNSLP CCCCEECEEECCCCC	24.89	27251789
348	Phosphorylation	INSVKLNSLPSEYES ECEEECCCCCCCCCC	52.69	23927012
351	Phosphorylation	VKLNSLPSEYESGSA EECCCCCCCCCCCCC	59.09	25394399
353	Phosphorylation	LNSLPSEYESGSACP CCCCCCCCCCCCCCC	21.52	27259358
355	Phosphorylation	SLPSEYESGSACPAQ CCCCCCCCCCCCCCC	36.83	27259358
357	Phosphorylation	PSEYESGSACPAQTV CCCCCCCCCCCCCEE	35.66	29978859
363	Phosphorylation	GSACPAQTVHYRPIN CCCCCCCEEEEEECC	16.03	29978859
366	Phosphorylation	CPAQTVHYRPINLSS CCCCEEEEEECCCCC	17.47	25394399
372	Phosphorylation	HYRPINLSSSENKIV EEEECCCCCCCCCEE	27.59	25850435
373	Phosphorylation	YRPINLSSSENKIVN EEECCCCCCCCCEEE	44.85	29255136
374	Phosphorylation	RPINLSSSENKIVNV EECCCCCCCCCEEEE	41.64	29255136
378 (in isoform 6)	Phosphorylation	-	4.03	27251275
382	O-linked_Glycosylation	ENKIVNVSLADLRGG CCCEEEEEHHHHCCC	16.79	30059200
382	O-linked_Glycosylation	ENKIVNVSLADLRGG CCCEEEEEHHHHCCC	16.79	20068230
382	Phosphorylation	ENKIVNVSLADLRGG CCCEEEEEHHHHCCC	16.79	29255136
388 (in isoform 6)	Phosphorylation	-	45.05	27251275
394	Phosphorylation	RGGNRPNTGPLYTEA CCCCCCCCCCCCCHH	42.74	21945579
398	Phosphorylation	RPNTGPLYTEADRVI CCCCCCCCCHHHHHH	12.98	21945579
399	Phosphorylation	PNTGPLYTEADRVIQ CCCCCCCCHHHHHHH	32.17	21945579
408	Phosphorylation	ADRVIQRTNSMQQLE HHHHHHHHCHHHHHH	18.44	30266825
410	Phosphorylation	RVIQRTNSMQQLEQW HHHHHHCHHHHHHHH	19.84	23927012
410 (in isoform 4)	Phosphorylation	-	19.84	21406692
416 (in isoform 6)	Phosphorylation	-	56.65	27251275
424	Methylation	WIKIQKGRGHEEETR HHHHHCCCCCCCHHC	50.78	54558061
435	Phosphorylation	EETRGVISYQTLPRN CHHCCEEEEECCCCC	14.58	30266825
436	Phosphorylation	ETRGVISYQTLPRNM HHCCEEEEECCCCCC	8.39	23927012
438	Phosphorylation	RGVISYQTLPRNMPS CCEEEEECCCCCCCC	30.42	19664994
444 (in isoform 6)	Phosphorylation	-	30.45	27251275
454	Phosphorylation	RAQIMARYPEGYRTL HHHHHHHCCCCCCCC	8.97	23403867
458	Phosphorylation	MARYPEGYRTLPRNS HHHCCCCCCCCCCCC	9.96	26657352
460	Phosphorylation	RYPEGYRTLPRNSKT HCCCCCCCCCCCCCC	32.41	30266825
460 (in isoform 6)	Phosphorylation	-	32.41	27251275
466 (in isoform 6)	Phosphorylation	-	52.69	27251275
467	Phosphorylation	TLPRNSKTRPESICS CCCCCCCCCCHHHCC	51.80	23403867
471	Phosphorylation	NSKTRPESICSVTPS CCCCCCHHHCCCCCC	31.42	22617229
474	Phosphorylation	TRPESICSVTPSTHD CCCHHHCCCCCCCCC	27.62	23403867
476	Phosphorylation	PESICSVTPSTHDKT CHHHCCCCCCCCCCC	8.67	25159151
477 (in isoform 6)	Phosphorylation	-	34.77	27251275
478	Phosphorylation	SICSVTPSTHDKTLG HHCCCCCCCCCCCCC	29.07	28387310
479	Phosphorylation	ICSVTPSTHDKTLGP HCCCCCCCCCCCCCC	34.98	23403867
480 (in isoform 6)	Phosphorylation	-	38.62	27251275
483	Phosphorylation	TPSTHDKTLGPGAEE CCCCCCCCCCCCHHH	42.90	22210691
488 (in isoform 8)	Phosphorylation	-	25.55	22210691
494	Phosphorylation	GAEEKRRSMRDDTMW CHHHHHHHCCCCHHH	23.39	22617229
494 (in isoform 8)	Phosphorylation	-	23.39	22210691
497 (in isoform 8)	Phosphorylation	-	47.28	22210691
499	Phosphorylation	RRSMRDDTMWQLYEW HHHCCCCHHHHHHHH	25.29	27134283
500 (in isoform 6)	Phosphorylation	-	2.49	27251275
504	Phosphorylation	DDTMWQLYEWQQRQF CCHHHHHHHHHHHHH	10.46	27259358
512	Phosphorylation	EWQQRQFYNKQSTLP HHHHHHHHCCCCCCC	17.08	-
522	Phosphorylation	QSTLPRHSTLSSPKT CCCCCCCCCCCCCCE	32.12	29396449
523	Phosphorylation	STLPRHSTLSSPKTM CCCCCCCCCCCCCEE	25.24	28857561
525	Phosphorylation	LPRHSTLSSPKTMVN CCCCCCCCCCCEEEE	44.69	25159151
526	Phosphorylation	PRHSTLSSPKTMVNI CCCCCCCCCCEEEEC	33.26	30576142
529	Phosphorylation	STLSSPKTMVNISDQ CCCCCCCEEEECCCC	29.72	27080861
534	Phosphorylation	PKTMVNISDQTMHSI CCEEEECCCCCCCCC	20.61	22199227
537	Phosphorylation	MVNISDQTMHSIPTS EEECCCCCCCCCCCC	23.11	22199227
540	Phosphorylation	ISDQTMHSIPTSPSH CCCCCCCCCCCCCCC	21.31	22199227
543	Phosphorylation	QTMHSIPTSPSHGSI CCCCCCCCCCCCCCC	52.15	26657352
544	Phosphorylation	TMHSIPTSPSHGSIA CCCCCCCCCCCCCCE	21.03	23403867
546	Phosphorylation	HSIPTSPSHGSIAAY CCCCCCCCCCCCEEC	40.00	26657352
549	Phosphorylation	PTSPSHGSIAAYQGY CCCCCCCCCEECCCC	12.02	22199227
550 (in isoform 6)	Phosphorylation	-	2.77	27251275
552 (in isoform 6)	Phosphorylation	-	8.77	27251275
553	Phosphorylation	SHGSIAAYQGYSPQR CCCCCEECCCCCCCC	8.08	23403867
556	Phosphorylation	SIAAYQGYSPQRTYR CCEECCCCCCCCCEE	11.14	23403867
557	Phosphorylation	IAAYQGYSPQRTYRS CEECCCCCCCCCEEC	22.75	22199227
561	Phosphorylation	QGYSPQRTYRSEVSS CCCCCCCCEECCCCC	20.31	21712546
562	Phosphorylation	GYSPQRTYRSEVSSP CCCCCCCEECCCCCC	17.84	21712546
563 (in isoform 6)	Phosphorylation	-	26.23	27251275
564	Phosphorylation	SPQRTYRSEVSSPIQ CCCCCEECCCCCCCC	31.75	20068231
567	Phosphorylation	RTYRSEVSSPIQRGD CCEECCCCCCCCCCC	26.75	21712546
568	Phosphorylation	TYRSEVSSPIQRGDV CEECCCCCCCCCCCC	31.06	19664994
573 (in isoform 6)	Phosphorylation	-	19.84	27251275
576	Phosphorylation	PIQRGDVTIDRRHRA CCCCCCCEECHHHHH	23.15	20068231
590	Phosphorylation	AHHPKHVYVPDRRSV HCCCCCEECCCCCCC	13.14	29496907
596	Phosphorylation	VYVPDRRSVPAGLTL EECCCCCCCCCCCEE	33.09	29255136
602	Phosphorylation	RSVPAGLTLQSVSPQ CCCCCCCEEEECCCC	23.10	24732914
602 (in isoform 6)	Phosphorylation	-	23.10	27251275
605	Phosphorylation	PAGLTLQSVSPQSLQ CCCCEEEECCCCHHC	27.89	28387310
607	Phosphorylation	GLTLQSVSPQSLQGK CCEEEECCCCHHCCC	23.59	30266825
607 (in isoform 3)	Phosphorylation	-	23.59	25159151
610	Phosphorylation	LQSVSPQSLQGKTLS EEECCCCHHCCCCCC	26.50	30266825
610 (in isoform 3)	Phosphorylation	-	26.50	25159151
613 (in isoform 6)	Phosphorylation	-	30.15	27251275
615	Phosphorylation	PQSLQGKTLSQDEGR CCHHCCCCCCCCCCC	38.17	22617229
617	Phosphorylation	SLQGKTLSQDEGRGT HHCCCCCCCCCCCCE	40.60	29214152
624	Phosphorylation	SQDEGRGTLYKYRPE CCCCCCCEEEECCHH	26.08	28857561
647	Acetylation	SRLCEQDKVVHALEE HHHHHHHHHHHHHHH	45.94	25953088
672	Phosphorylation	TLEQALLSASQEIEM HHHHHHHHHHHHHHH	27.07	24719451
674	Phosphorylation	EQALLSASQEIEMHA HHHHHHHHHHHHHHC	25.60	28348404
709	Phosphorylation	LSTCRELSRATAELE HHHHHHHHHHHHHHH	18.34	23403867
712	Phosphorylation	CRELSRATAELERAW HHHHHHHHHHHHHHH	21.39	23403867
712 (in isoform 8)	Phosphorylation	-	21.39	22468782
716 (in isoform 8)	Phosphorylation	-	31.68	22468782
781	Phosphorylation	KHKQQRGTTEIGMIG HHHHHCCCCEEEEEC	24.36	20068231
781 (in isoform 5)	Phosphorylation	-	24.36	24275569
782	Phosphorylation	HKQQRGTTEIGMIGS HHHHCCCCEEEEECC	28.56	20068231
782 (in isoform 5)	Phosphorylation	-	28.56	24275569
786 (in isoform 5)	Phosphorylation	-	3.73	24275569
789	Phosphorylation	TEIGMIGSKPFSTVK CEEEEECCCCCCCEE	26.65	20068231
789 (in isoform 8)	Phosphorylation	-	26.65	29507054
791 (in isoform 8)	Phosphorylation	-	30.07	29507054
793	Phosphorylation	MIGSKPFSTVKYKNE EECCCCCCCEEECCC	40.60	28555341
793 (in isoform 4)	Phosphorylation	-	40.60	22468782
794	Phosphorylation	IGSKPFSTVKYKNEG ECCCCCCCEEECCCC	22.77	28857561
797	Phosphorylation	KPFSTVKYKNEGPDY CCCCCEEECCCCCCC	18.08	22468782
797 (in isoform 4)	Phosphorylation	-	18.08	22468782
804	Phosphorylation	YKNEGPDYRLYKSEP ECCCCCCCCCCCCCC	12.97	27259358
807	Phosphorylation	EGPDYRLYKSEPELT CCCCCCCCCCCCCCE	11.94	30576142
809	Phosphorylation	PDYRLYKSEPELTTV CCCCCCCCCCCCEEE	44.84	19664994
814	Phosphorylation	YKSEPELTTVAEVDE CCCCCCCEEEEEECC	19.98	30266825
815	Phosphorylation	KSEPELTTVAEVDES CCCCCCEEEEEECCC	30.28	30266825
822	Phosphorylation	TVAEVDESNGEEKSE EEEEECCCCCCCCCC	45.75	26657352
828	Phosphorylation	ESNGEEKSEPVSEIE CCCCCCCCCCCCEEE	50.87	26657352
832	Phosphorylation	EEKSEPVSEIETSVV CCCCCCCCEEEEEEE	43.50	26657352
836	Phosphorylation	EPVSEIETSVVKGSH CCCCEEEEEEECCCC	32.27	25850435
837	Phosphorylation	PVSEIETSVVKGSHF CCCEEEEEEECCCCC	16.48	25850435
842	Phosphorylation	ETSVVKGSHFPVGVV EEEEECCCCCCCCCC	19.08	-
855	Phosphorylation	VVPPRAKSPTPESST CCCCCCCCCCCCHHH	32.78	19664994
857	Phosphorylation	PPRAKSPTPESSTIA CCCCCCCCCCHHHHH	46.94	29255136
860	Phosphorylation	AKSPTPESSTIASYV CCCCCCCHHHHHHHH	33.70	25463755
861	Phosphorylation	KSPTPESSTIASYVT CCCCCCHHHHHHHHH	23.36	30266825
862	Phosphorylation	SPTPESSTIASYVTL CCCCCHHHHHHHHHH	29.82	29255136
862 (in isoform 2)	Phosphorylation	-	29.82	27642862
865	Phosphorylation	PESSTIASYVTLRKT CCHHHHHHHHHHHHC	19.11	29255136
866	Phosphorylation	ESSTIASYVTLRKTK CHHHHHHHHHHHHCC	6.61	29255136
868	Phosphorylation	STIASYVTLRKTKKM HHHHHHHHHHHCCHH	16.77	29255136
870 (in isoform 4)	Phosphorylation	-	34.92	29507054
872	Phosphorylation	SYVTLRKTKKMMDLR HHHHHHHCCHHHCCC	29.48	-
872 (in isoform 4)	Phosphorylation	-	29.48	21406692
880	Phosphorylation	KKMMDLRTERPRSAV CHHHCCCCCCCHHHH	43.58	23312004
885	Phosphorylation	LRTERPRSAVEQLCL CCCCCCHHHHHHHHH	39.07	30266825
895	Phosphorylation	EQLCLAESTRPRMTV HHHHHHCCCCCCCCH	24.90	23312004
896	Phosphorylation	QLCLAESTRPRMTVE HHHHHCCCCCCCCHH	35.88	23312004
896 (in isoform 6)	Phosphorylation	-	35.88	22468782
900 (in isoform 6)	Phosphorylation	-	5.65	22468782
918 (in isoform 4)	Phosphorylation	-	54.28	21406692
920 (in isoform 4)	Phosphorylation	-	54.04	21406692
923 (in isoform 4)	Phosphorylation	-	31.22	21406692
925 (in isoform 4)	Phosphorylation	-	31.84	21406692
930	Phosphorylation	GLNVIGASDQSPLQS CCCCCCCCCCCCCCC	30.85	30266825
933	Phosphorylation	VIGASDQSPLQSPSN CCCCCCCCCCCCCCC	32.35	29255136
937	Phosphorylation	SDQSPLQSPSNLRDN CCCCCCCCCCCCCCC	37.67	29255136
939	Phosphorylation	QSPLQSPSNLRDNPF CCCCCCCCCCCCCCC	54.46	30266825
951	Phosphorylation	NPFRTTQTRRRDDKE CCCCCCHHHCCCHHH	24.85	22210691
973 (in isoform 6)	Phosphorylation	-	64.96	29507054
974	Phosphorylation	DVKPDHETPATEIVQ CCCCCCCCCCCEEEE	18.14	28857561
975 (in isoform 6)	Phosphorylation	-	33.91	29507054
977	Phosphorylation	PDHETPATEIVQLKE CCCCCCCCEEEECCC	27.70	23312004
980 (in isoform 6)	Phosphorylation	-	4.43	27251275
994 (in isoform 6)	Phosphorylation	-	68.04	27251275
998 (in isoform 6)	Phosphorylation	-	73.94	27251275
999	Phosphorylation	FSKELKKTENISYEM CCHHHHCCCCCCEEE	32.45	25907765
1003	Phosphorylation	LKKTENISYEMLFEP HHCCCCCCEEEEECC	26.99	25907765
1003 (in isoform 6)	Phosphorylation	-	26.99	27251275
1004	Phosphorylation	KKTENISYEMLFEPE HCCCCCCEEEEECCC	11.10	25907765
1017	Phosphorylation	PEPNGVNSVEMMDKE CCCCCCCCCCCCCCH	19.63	25907765
1021 (in isoform 6)	Phosphorylation	-	4.16	27251275
1035	Phosphorylation	DKMPEDVTFSPQDET CCCCCCCCCCCCCCC	30.62	28555341
1037	Phosphorylation	MPEDVTFSPQDETQT CCCCCCCCCCCCCCC	16.58	28985074
1051 (in isoform 6)	Phosphorylation	-	73.58	27251275
1067	Phosphorylation	SVDEQEETVISYEST CCCHHHCEEEEEECC	23.53	28796482
1070	Phosphorylation	EQEETVISYESTPEV HHHCEEEEEECCCCC	20.64	28796482
1071	Phosphorylation	QEETVISYESTPEVS HHCEEEEEECCCCCC	11.63	28796482
1073	Phosphorylation	ETVISYESTPEVSRG CEEEEEECCCCCCCC	40.82	28796482
1074	Phosphorylation	TVISYESTPEVSRGN EEEEEECCCCCCCCC	16.13	28796482
1083	Phosphorylation	EVSRGNQTMAVKSLS CCCCCCEEEEEEECC	15.88	-
1088	Phosphorylation	NQTMAVKSLSPSPES CEEEEEEECCCCCCC	27.72	28450419
1090	Phosphorylation	TMAVKSLSPSPESSA EEEEEECCCCCCCCC	30.35	28450419
1092	Phosphorylation	AVKSLSPSPESSASP EEEECCCCCCCCCCC	37.61	28450419
1095	Phosphorylation	SLSPSPESSASPVPS ECCCCCCCCCCCCCC	34.29	28450419
1096	Phosphorylation	LSPSPESSASPVPST CCCCCCCCCCCCCCC	30.98	28450419
1098	Phosphorylation	PSPESSASPVPSTQP CCCCCCCCCCCCCCC	28.51	25627689
1099 (in isoform 6)	Phosphorylation	-	41.58	27251275
1102	Phosphorylation	SSASPVPSTQPQLTE CCCCCCCCCCCCCCC	39.65	27080861
1103	Phosphorylation	SASPVPSTQPQLTEG CCCCCCCCCCCCCCC	37.89	27080861
1103 (in isoform 6)	Phosphorylation	-	37.89	27251275
1169 (in isoform 6)	Phosphorylation	-		27251275
1258 (in isoform 6)	Phosphorylation	-		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PKHA5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKHA5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKHA5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DESM_HUMAN	DES	physical	20936779
EVPL_HUMAN	EVPL	physical	20936779
EXTL3_HUMAN	EXTL3	physical	20936779
K1C19_HUMAN	KRT19	physical	20936779
KTN1_HUMAN	KTN1	physical	20936779
LAMB2_HUMAN	LAMB2	physical	20936779
PLEC_HUMAN	PLEC	physical	20936779
SPTN1_HUMAN	SPTAN1	physical	20936779
SPTB2_HUMAN	SPTBN1	physical	20936779
PROM1_HUMAN	PROM1	physical	20936779
CE350_HUMAN	CEP350	physical	20936779
KIF3A_HUMAN	KIF3A	physical	20936779
CP250_HUMAN	CEP250	physical	20936779
PKHA6_HUMAN	PLEKHA6	physical	20936779
ARHG9_HUMAN	ARHGEF9	physical	20936779
ASPP1_HUMAN	PPP1R13B	physical	20936779
BL1S6_HUMAN	BLOC1S6	physical	20936779
K1C20_HUMAN	KRT20	physical	20936779
PKHA5_HUMAN	PLEKHA5	physical	20936779
CC186_HUMAN	CCDC186	physical	20936779
CCD92_HUMAN	CCDC92	physical	20936779
3BP5L_HUMAN	SH3BP5L	physical	20936779
CC88B_HUMAN	CCDC88B	physical	20936779
KANL1_HUMAN	KANSL1	physical	20936779
SOGA1_HUMAN	SOGA1	physical	20936779
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
LIMA1_HUMAN	LIMA1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
AGAP1_HUMAN	AGAP1	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKHA5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-933, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410; SER-568; SER-607;SER-930; SER-933 AND SER-937, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-855; SER-933 ANDSER-937, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-438; THR-476; SER-933AND SER-937, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction."; Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.; Mol. Cell. Proteomics 6:1952-1967(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-855, AND MASSSPECTROMETRY.	17693683 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-855; THR-857; SER-933AND SER-937, AND MASS SPECTROMETRY.	17081983 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-134 AND TYR-353, ANDMASS SPECTROMETRY.	19534553 [Abstract]
"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules."; Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.; Mol. Cell. Proteomics 4:1240-1250(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-128 AND TYR-134, ANDMASS SPECTROMETRY.	15951569 [Abstract]