EXTL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXTL3_HUMAN
• UniProt AC: O43909
• Protein Name: Exostosin-like 3 {ECO:0000303|PubMed:9479495}
• Gene Name: EXTL3 {ECO:0000312|HGNC:HGNC:3518}
• Organism: Homo sapiens (Human).
• Sequence Length: 919
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus .
• Protein Description: Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). [PubMed: 28132690]
• Protein Sequence: MTGYTMLRNGGAGNGGQTCMLRWSNRIRLTWLSFTLFVILVFFPLIAHYYLTTLDEADEAGKRIFGPRVGNELCEVKHVLDLCRIRESVSEELLQLEAKRQELNSEIAKLNLKIEACKKSIENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLLPEKDDAGLPPPKATRGCRLHNCFDYSRCPLTSGFPVYVYDSDQFVFGSYLDPLVKQAFQATARANVYVTENADIACLYVILVGEMQEPVVLRPAELEKQLYSLPHWRTDGHNHVIINLSRKSDTQNLLYNVSTGRAMVAQSTFYTVQYRPGFDLVVSPLVHAMSEPNFMEIPPQVPVKRKYLFTFQGEKIESLRSSLQEARSFEEEMEGDPPADYDDRIIATLKAVQDSKLDQVLVEFTCKNQPKPSLPTEWALCGEREDRLELLKLSTFALIITPGDPRLVISSGCATRLFEALEVGAVPVVLGEQVQLPYQDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFNTVLAMIRTRIQIPAAPIREEAAAEIPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASPRYLRNFTLTVTDFYRSWNCAPGPFHLFPHTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVPREQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMVVRTEKNSLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDIPHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITRKPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLPHDKTKCFKFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTGYTMLRN ------CCCCEEEEC	38.61	23532336
4	Phosphorylation	----MTGYTMLRNGG ----CCCCEEEECCC	4.64	28796482
5	Phosphorylation	---MTGYTMLRNGGA ---CCCCEEEECCCC	15.86	28796482
99	Ubiquitination	ELLQLEAKRQELNSE HHHHHHHHHHHHHHH	45.28	-
118	Acetylation	NLKIEACKKSIENAK HHHHHHHHHHHHHHH	57.51	6570381
125	Acetylation	KKSIENAKQDLLQLK HHHHHHHHHHHHHHH	56.79	6570289
138	O-linked_Glycosylation	LKNVISQTEHSYKEL HHHHHHHCHHHHHHH	28.95	OGP
142	Phosphorylation	ISQTEHSYKELMAQN HHHCHHHHHHHHHHC	15.47	-
154	Phosphorylation	AQNQPKLSLPIRLLP HHCCCCCCCCEEECC	37.92	24719451
277	N-linked_Glycosylation	GHNHVIINLSRKSDT CCCEEEEECCCCCCC	22.34	UniProtKB CARBOHYD
290	N-linked_Glycosylation	DTQNLLYNVSTGRAM CCCCEEEECCCCCEE	22.64	UniProtKB CARBOHYD
352	Phosphorylation	FQGEKIESLRSSLQE ECHHHHHHHHHHHHH	32.34	24702127
362	Phosphorylation	SSLQEARSFEEEMEG HHHHHHHHHHHHHCC	44.02	26471730
389	Phosphorylation	TLKAVQDSKLDQVLV HHHHHHCCCCCEEEE	20.30	24719451
401	Acetylation	VLVEFTCKNQPKPSL EEEEEECCCCCCCCC	56.40	7825943
499	Phosphorylation	EVHFLLRSLSDSDLL HHHHHHHHCCHHHHH	31.99	-
501	Phosphorylation	HFLLRSLSDSDLLAM HHHHHHCCHHHHHHH	35.99	-
521	Phosphorylation	FLWETYFSTADSIFN HHHHHHCHHHHHHHH	16.57	29978859
522	Phosphorylation	LWETYFSTADSIFNT HHHHHCHHHHHHHHH	25.28	29978859
525	Phosphorylation	TYFSTADSIFNTVLA HHCHHHHHHHHHHHH	26.98	29978859
529	Phosphorylation	TADSIFNTVLAMIRT HHHHHHHHHHHHHHH	13.22	29978859
557	Phosphorylation	AAEIPHRSGKAAGTD HHHCCCCCCCCCCCC	41.43	23532336
563	O-linked_Glycosylation	RSGKAAGTDPNMADN CCCCCCCCCCCCCCC	43.48	OGP
580	O-linked_Glycosylation	LDLGPVETEPPYASP CCCCCCCCCCCCCCC	54.76	OGP
589	Phosphorylation	PPYASPRYLRNFTLT CCCCCCHHHCCEEEE	17.25	23532336
592	N-linked_Glycosylation	ASPRYLRNFTLTVTD CCCHHHCCEEEEEEH	31.49	UniProtKB CARBOHYD
790	N-linked_Glycosylation	QSWLYNSNYSCELSM CHHHCCCCCCEEEEE	29.15	UniProtKB CARBOHYD
853	Phosphorylation	KPPIKVTSRWTFRCP CCCEEEEEEEEEECC	28.89	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXTL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXTL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXTL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XIAP_HUMAN	XIAP	physical	12021770

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.