ARHG9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARHG9_HUMAN
• UniProt AC: O43307
• Protein Name: Rho guanine nucleotide exchange factor 9
• Gene Name: ARHGEF9
• Organism: Homo sapiens (Human).
• Sequence Length: 516
• Subcellular Localization: Cytoplasm .
• Protein Description: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters..
• Protein Sequence: MTLLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTLLITGDS ------CEEEEECCC	30.21	30576742
41	Phosphorylation	VIKVLDASNKDWWWG EEEEEECCCCCCEEE	44.04	-
113	Phosphorylation	NVINEIMSTERHYIK HHHHHHHHHHHHHHH	32.55	26503892
114	Phosphorylation	VINEIMSTERHYIKH HHHHHHHHHHHHHHH	21.47	30631047
116	Dimethylation	NEIMSTERHYIKHLK HHHHHHHHHHHHHHH	28.18	-
116	Methylation	NEIMSTERHYIKHLK HHHHHHHHHHHHHHH	28.18	-
131	Trimethylation	DICEGYLKQCRKRRD HHHHHHHHHHHHHHC	38.58	-
131	Methylation	DICEGYLKQCRKRRD HHHHHHHHHHHHHHC	38.58	23644510
141	Phosphorylation	RKRRDMFSDEQLKVI HHHHCCCCHHHHHHH	33.33	27499020
260	Phosphorylation	LAELLKYTAQDHSDY HHHHHHHHCCCCCCH	19.09	22210691
267	Phosphorylation	TAQDHSDYRYVAAAL HCCCCCCHHHHHHHH	13.58	22210691
269	Phosphorylation	QDHSDYRYVAAALAV CCCCCHHHHHHHHHH	6.55	22210691
408	Ubiquitination	EIHLFFAKKLEEKIR HEEEHHHHHHHHHHH	53.38	-
413	Ubiquitination	FAKKLEEKIRWLRAF HHHHHHHHHHHHHHH	28.35	-
500	Phosphorylation	EFTEPKRSQSPFWQN ECCCCCCCCCCCCCC	40.93	27732954
502	Phosphorylation	TEPKRSQSPFWQNFS CCCCCCCCCCCCCCC	24.26	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARHG9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARHG9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARHG9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GEPH_HUMAN	GPHN	physical	10607391
SMUF1_HUMAN	SMURF1	physical	18208356

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.