| UniProt ID | CP250_HUMAN | |
|---|---|---|
| UniProt AC | Q9BV73 | |
| Protein Name | Centrosome-associated protein CEP250 | |
| Gene Name | CEP250 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 2442 | |
| Subcellular Localization | Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Component of the core centrosome. In interphase cells, it specifically associates with the pr | |
| Protein Description | Probably plays an important role in centrosome cohesion during interphase.. | |
| Protein Sequence | METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVLLHPSPSTTQAASR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----METRSPGLNN -----CCCCCCCCCC | 48.59 | 23663014 | |
| 5 | Phosphorylation | ---METRSPGLNNMK ---CCCCCCCCCCCC | 30.64 | 23663014 | |
| 12 | Acetylation | SPGLNNMKPQSLQLV CCCCCCCCHHHHHHH | 41.87 | 11688535 | |
| 20 | Ubiquitination | PQSLQLVLEEQVLAL HHHHHHHHHHHHHHH | 9.01 | 29967540 | |
| 38 | Ubiquitination | MAENQAASWRKLKNS HHHHHHHHHHHHHCH | 30.35 | 32015554 | |
| 45 | Phosphorylation | SWRKLKNSQEAQQRQ HHHHHHCHHHHHHHH | 28.01 | 27251275 | |
| 54 | Phosphorylation | EAQQRQATLVRKLQA HHHHHHHHHHHHHHH | 19.90 | - | |
| 62 | Ubiquitination | LVRKLQAKVLQYRSW HHHHHHHHHHHHHHH | 30.43 | - | |
| 75 | Ubiquitination | SWCQELEKRLEATGG HHHHHHHHHHHHHCC | 74.94 | 29967540 | |
| 112 | Phosphorylation | EEQQRCESLAEVNTQ HHHHHHHHHHHHHHH | 36.18 | 26657352 | |
| 118 | Phosphorylation | ESLAEVNTQLRLHME HHHHHHHHHHHHHHH | 33.87 | 26657352 | |
| 126 | Ubiquitination | QLRLHMEKADVVNKA HHHHHHHHHHHHHHH | 42.17 | 29967540 | |
| 132 | Ubiquitination | EKADVVNKALREDVE HHHHHHHHHHHHHHH | 36.87 | 29967540 | |
| 155 | Ubiquitination | ARDELMRKESQWQME HHHHHHHHHHHHHHH | 47.99 | 29967540 | |
| 167 | Ubiquitination | QMEQEFFKGYLKGEH HHHHHHHHHHHCCCC | 52.55 | 29967540 | |
| 179 | Phosphorylation | GEHGRLLSLWREVVT CCCHHHHHHHHHHHH | 30.40 | 24719451 | |
| 186 | Phosphorylation | SLWREVVTFRRHFLE HHHHHHHHHHHHHHH | 19.32 | - | |
| 206 | Ubiquitination | DRDLMELKAEHVRLS CHHHHHHHHHHHHHH | 38.12 | - | |
| 252 | Ubiquitination | QLLLLLAKTQELEKE HHHHHHHHHHHHHHH | 51.19 | - | |
| 253 | Phosphorylation | LLLLLAKTQELEKEA HHHHHHHHHHHHHHH | 22.97 | - | |
| 260 | Ubiquitination | TQELEKEAHERSQEL HHHHHHHHHHHHHHH | 22.40 | 29967540 | |
| 264 | Phosphorylation | EKEAHERSQELIQLK HHHHHHHHHHHHHHH | 25.64 | 25159151 | |
| 271 | Ubiquitination | SQELIQLKSQGDLEK HHHHHHHHHHCCHHH | 25.10 | 29967540 | |
| 286 | Phosphorylation | AELQDRVTELSALLT HHHHHHHHHHHHHHH | 31.91 | 29978859 | |
| 289 | Phosphorylation | QDRVTELSALLTQSQ HHHHHHHHHHHHHHH | 15.61 | 29978859 | |
| 293 | Phosphorylation | TELSALLTQSQKQNE HHHHHHHHHHHHHCH | 27.33 | 29978859 | |
| 295 | Phosphorylation | LSALLTQSQKQNEDY HHHHHHHHHHHCHHH | 33.82 | 29978859 | |
| 297 | Acetylation | ALLTQSQKQNEDYEK HHHHHHHHHCHHHHH | 61.41 | 11790007 | |
| 297 | Ubiquitination | ALLTQSQKQNEDYEK HHHHHHHHHCHHHHH | 61.41 | 29967540 | |
| 302 | Phosphorylation | SQKQNEDYEKMIKAL HHHHCHHHHHHHHHH | 15.98 | 29978859 | |
| 324 | Ubiquitination | ETNHTELMEHEASLS HCCHHHHHHHHHHHC | 3.93 | 29967540 | |
| 329 | Phosphorylation | ELMEHEASLSRNAQE HHHHHHHHHCCHHHH | 24.72 | 27174698 | |
| 331 | Phosphorylation | MEHEASLSRNAQEEK HHHHHHHCCHHHHHH | 22.46 | 27174698 | |
| 338 | Ubiquitination | SRNAQEEKLSLQQVI CCHHHHHHHCHHHHH | 42.49 | 29967540 | |
| 378 | Ubiquitination | LDSSIFSQFDYQDAD CCHHHHHCCCCCCHH | 25.20 | 29967540 | |
| 384 | Ubiquitination | SQFDYQDADKALTLV HCCCCCCHHHHHHHH | 12.51 | 29967540 | |
| 404 | Ubiquitination | RRRQAVQDLRQQLAG HHHHHHHHHHHHHHH | 36.90 | 29967540 | |
| 416 | Ubiquitination | LAGCQEAVNLLQQQH HHHHHHHHHHHHHHH | 5.22 | 21890473 | |
| 441 | Phosphorylation | RQRLQKLTGERDTLA HHHHHHHHCCCCCCC | 43.99 | 24719451 | |
| 446 | Phosphorylation | KLTGERDTLAGQTVD HHHCCCCCCCCCCCC | 25.40 | 23684312 | |
| 460 | Phosphorylation | DLQGEVDSLSKEREL CCHHHHCCHHHHHHH | 39.45 | 26471730 | |
| 462 | Phosphorylation | QGEVDSLSKERELLQ HHHHCCHHHHHHHHH | 36.10 | 23684312 | |
| 463 | Ubiquitination | GEVDSLSKERELLQK HHHCCHHHHHHHHHH | 67.11 | 29967540 | |
| 502 | Phosphorylation | ELQLQGDSAQGQKEE EEEECCCCCCCCHHH | 29.35 | 20068231 | |
| 516 | Ubiquitination | EQQEELHLAVRERER HHHHHHHHHHHHHHH | 8.03 | 21890473 | |
| 552 | Phosphorylation | LREALESSHLEGELL HHHHHHHCCCCHHHH | 23.79 | 28555341 | |
| 576 | Phosphorylation | ALARAEQSIAELSSS HHHHHHHHHHHHHCC | 18.44 | 20068231 | |
| 581 | Phosphorylation | EQSIAELSSSENTLK HHHHHHHHCCCCCCH | 24.27 | 20068231 | |
| 582 | Phosphorylation | QSIAELSSSENTLKT HHHHHHHCCCCCCHH | 55.05 | 20068231 | |
| 582 | Ubiquitination | QSIAELSSSENTLKT HHHHHHHCCCCCCHH | 55.05 | 21890473 | |
| 583 | Phosphorylation | SIAELSSSENTLKTE HHHHHHCCCCCCHHH | 31.33 | 20068231 | |
| 586 | Phosphorylation | ELSSSENTLKTEVAD HHHCCCCCCHHHHHH | 26.11 | 20068231 | |
| 588 | Ubiquitination | SSSENTLKTEVADLR HCCCCCCHHHHHHHH | 40.37 | 29967540 | |
| 600 | Ubiquitination | DLRAAAVKLSALNEA HHHHHHHHHHHHHHH | 31.81 | 29967540 | |
| 622 | Ubiquitination | LNQQLLQLEEENQSV CCHHHHHHHHHHHHH | 10.11 | 33845483 | |
| 636 | Ubiquitination | VCSRMEAAEQARNAL HHHHHHHHHHHHHHH | 8.98 | 29967540 | |
| 648 | Ubiquitination | NALQVDLAEAEKRRE HHHHHHHHHHHHHHH | 14.97 | 29967540 | |
| 652 | Ubiquitination | VDLAEAEKRREALWE HHHHHHHHHHHHHHH | 64.90 | 29967540 | |
| 670 | Ubiquitination | HLEAQLQKAEEAGAE HHHHHHHHHHHHHHH | 67.37 | 32015554 | |
| 682 | Ubiquitination | GAELQADLRDIQEEK HHHHHHHHHHHHHHH | 6.25 | 21890473 | |
| 699 | Phosphorylation | IQKKLSESRHQQEAA HHHHHHHHHHHHHHH | 31.52 | - | |
| 780 | Ubiquitination | LFEAQQQNSVIEVTK HHHHHHHCCEEEEEC | 33.63 | 32015554 | |
| 785 | Ubiquitination | QQNSVIEVTKGQLEV HHCCEEEEECCEEEE | 4.62 | 29967540 | |
| 804 | Ubiquitination | VTQAKEVIQGEVRCL HHHHHHHHHCCHHHE | 4.58 | 21890473 | |
| 817 | Ubiquitination | CLKLELDTERSQAEQ HEEEECCCHHHHHHH | 46.02 | 29967540 | |
| 834 | Ubiquitination | DAAARQLAQAEQEGK HHHHHHHHHHHHHHH | 9.74 | 32015554 | |
| 842 | Phosphorylation | QAEQEGKTALEQQKA HHHHHHHHHHHHHHH | 47.54 | - | |
| 846 | Ubiquitination | EGKTALEQQKAAHEK HHHHHHHHHHHHHHH | 51.42 | 21890473 | |
| 852 | Ubiquitination | EQQKAAHEKEVNQLR HHHHHHHHHHHHHHH | 46.30 | 29967540 | |
| 870 | Ubiquitination | EKERSWHQQELAKAL HHHHHHHHHHHHHHH | 31.98 | 29967540 | |
| 892 | Ubiquitination | MELEMRLKEQQTEME HHHHHHHHHHHHHHH | 43.01 | 29967540 | |
| 901 | Ubiquitination | QQTEMEAIQAQREEE HHHHHHHHHHHHHHH | 1.91 | 29967540 | |
| 904 | Ubiquitination | EMEAIQAQREEERTQ HHHHHHHHHHHHHHH | 36.62 | 21890473 | |
| 925 | Ubiquitination | QMQLETEKERVSLLE HHHHHCHHHHHHHHH | 59.23 | 21890473 | |
| 929 | Phosphorylation | ETEKERVSLLETLLQ HCHHHHHHHHHHHHH | 33.20 | 20860994 | |
| 933 | Phosphorylation | ERVSLLETLLQTQKE HHHHHHHHHHHHHHH | 32.51 | - | |
| 942 | Ubiquitination | LQTQKELADASQQLE HHHHHHHHHHHHHHH | 16.06 | 23000965 | |
| 945 | Ubiquitination | QKELADASQQLERLR HHHHHHHHHHHHHHH | 21.00 | 21890473 | |
| 946 | Ubiquitination | KELADASQQLERLRQ HHHHHHHHHHHHHHH | 54.31 | 21890473 | |
| 956 | Ubiquitination | ERLRQDMKVQKLKEQ HHHHHHHHHHHHHHH | 50.21 | 29967540 | |
| 971 | Phosphorylation | ETTGILQTQLQEAQR HHHHHHHHHHHHHHH | 28.00 | - | |
| 971 | Ubiquitination | ETTGILQTQLQEAQR HHHHHHHHHHHHHHH | 28.00 | 21890473 | |
| 992 (in isoform 2) | Ubiquitination | - | 17.08 | 21890473 | |
| 1010 | Ubiquitination | QDKMDLQKQVEDLKS HHHHHHHHHHHHHHH | 64.70 | 29967540 | |
| 1016 | Ubiquitination | QKQVEDLKSQLVAQD HHHHHHHHHHHHHCC | 48.77 | 29967540 | |
| 1025 | Ubiquitination | QLVAQDDSQRLVEQE HHHHCCHHHHHHHHH | 26.03 | 21890473 | |
| 1032 | Ubiquitination | SQRLVEQEVQEKLRE HHHHHHHHHHHHHHH | 32.44 | 32015554 | |
| 1036 | Ubiquitination | VEQEVQEKLRETQEY HHHHHHHHHHHHHHH | 35.43 | 29967540 | |
| 1040 | Phosphorylation | VQEKLRETQEYNRIQ HHHHHHHHHHHHHHH | 21.92 | - | |
| 1047 | Ubiquitination | TQEYNRIQKELEREK HHHHHHHHHHHHHHH | 29.90 | 29967540 | |
| 1048 | Acetylation | QEYNRIQKELEREKA HHHHHHHHHHHHHHH | 62.99 | 19608861 | |
| 1048 | Ubiquitination | QEYNRIQKELEREKA HHHHHHHHHHHHHHH | 62.99 | 22817900 | |
| 1048 (in isoform 1) | Ubiquitination | - | 62.99 | 21890473 | |
| 1056 | Phosphorylation | ELEREKASLTLSLME HHHHHHHHHHHHHHH | 32.71 | 20068231 | |
| 1057 | Ubiquitination | LEREKASLTLSLMEK HHHHHHHHHHHHHHH | 7.16 | 29967540 | |
| 1058 | Phosphorylation | EREKASLTLSLMEKE HHHHHHHHHHHHHHH | 16.29 | 20068231 | |
| 1060 | Phosphorylation | EKASLTLSLMEKEQR HHHHHHHHHHHHHHH | 22.04 | 20068231 | |
| 1071 | Ubiquitination | KEQRLLVLQEADSIR HHHHHHHHHCHHHHH | 3.72 | 21890473 | |
| 1082 | Ubiquitination | DSIRQQELSALRQDM HHHHHHHHHHHHHHH | 2.93 | 24816145 | |
| 1092 (in isoform 2) | Ubiquitination | - | 13.04 | 21890473 | |
| 1100 | Phosphorylation | QGEQKELSAQMELLR HHHHHHHHHHHHHHH | 19.97 | 26074081 | |
| 1108 | Ubiquitination | AQMELLRQEVKEKEA HHHHHHHHHHHHHHH | 60.86 | 23000965 | |
| 1111 | Ubiquitination | ELLRQEVKEKEADFL HHHHHHHHHHHHHHH | 63.42 | 21890473 | |
| 1148 | Ubiquitination | SLWAQEAKAAQLQLR HHHHHHHHHHHHHHH | 43.43 | 23000965 | |
| 1148 (in isoform 1) | Ubiquitination | - | 43.43 | 21890473 | |
| 1165 | Ubiquitination | STESQLEALAAEQQP CCHHHHHHHHHHCCC | 15.87 | 29967540 | |
| 1223 | Ubiquitination | LEPDQNGARSLFKRG CCCCCCCCCCHHHHC | 12.87 | 32015554 | |
| 1225 | Phosphorylation | PDQNGARSLFKRGPL CCCCCCCCHHHHCCH | 37.31 | 24719451 | |
| 1233 | Ubiquitination | LFKRGPLLTALSAEA HHHHCCHHHHHCHHH | 2.72 | 29967540 | |
| 1237 | Phosphorylation | GPLLTALSAEAVASA CCHHHHHCHHHHHHH | 22.92 | 24247654 | |
| 1248 | Ubiquitination | VASALHKLHQDLWKT HHHHHHHHHHHHHHH | 2.82 | 24816145 | |
| 1254 | Ubiquitination | KLHQDLWKTQQTRDV HHHHHHHHHHHHHHH | 43.69 | 33845483 | |
| 1268 | Ubiquitination | VLRDQVQKLEERLTD HHHHHHHHHHHHHCC | 60.04 | 29967540 | |
| 1269 | Ubiquitination | LRDQVQKLEERLTDT HHHHHHHHHHHHCCC | 4.64 | 29967540 | |
| 1280 | Ubiquitination | LTDTEAEKSQVHTEL HCCCHHHHHHHHHHH | 53.92 | 29967540 | |
| 1295 | Phosphorylation | QDLQRQLSQNQEEKS HHHHHHHHHCHHHHH | 20.81 | 26471730 | |
| 1304 | Ubiquitination | NQEEKSKWEGKQNSL CHHHHHHHHHHHHHH | 27.02 | 32015554 | |
| 1310 | Phosphorylation | KWEGKQNSLESELME HHHHHHHHHHHHHHH | 30.90 | 18452278 | |
| 1313 | Phosphorylation | GKQNSLESELMELHE HHHHHHHHHHHHHHH | 41.12 | 18452278 | |
| 1324 | Phosphorylation | ELHETMASLQSRLRR HHHHHHHHHHHHHHH | 19.00 | 18452278 | |
| 1330 | Ubiquitination | ASLQSRLRRAELQRM HHHHHHHHHHHHHHH | 34.35 | 23000965 | |
| 1333 | Ubiquitination | QSRLRRAELQRMEAQ HHHHHHHHHHHHHHH | 43.56 | 21890473 | |
| 1340 | Ubiquitination | ELQRMEAQGERELLQ HHHHHHHHHHHHHHH | 40.76 | 29967540 | |
| 1348 | Ubiquitination | GERELLQAAKENLTA HHHHHHHHHHHHHHH | 22.07 | 29967540 | |
| 1372 | Phosphorylation | VEARAQASAAGILEE HHHHHHHHHCCCHHH | 13.43 | 23917254 | |
| 1372 | Ubiquitination | VEARAQASAAGILEE HHHHHHHHHCCCHHH | 13.43 | 23000965 | |
| 1375 | Ubiquitination | RAQASAAGILEEDLR HHHHHHCCCHHHHHH | 25.40 | 21890473 | |
| 1386 | Phosphorylation | EDLRTARSALKLKNE HHHHHHHHHHHHCHH | 35.17 | - | |
| 1412 | Ubiquitination | LQEQGELKVAQGKAL HHHHCCHHHHHHHHH | 31.08 | 32015554 | |
| 1417 | Ubiquitination | ELKVAQGKALQENLA CHHHHHHHHHHHHHH | 33.57 | 29967540 | |
| 1431 | Ubiquitination | ALLTQTLAEREEEVE HHHHHHHHHHHHHHH | 19.72 | 29967540 | |
| 1439 | Phosphorylation | EREEEVETLRGQIQE HHHHHHHHHHHHHHH | 27.25 | 30108239 | |
| 1445 | Ubiquitination | ETLRGQIQELEKQRE HHHHHHHHHHHHHHH | 41.14 | 29967540 | |
| 1449 | Ubiquitination | GQIQELEKQREMQKA HHHHHHHHHHHHHHH | 68.24 | 29967540 | |
| 1451 | Ubiquitination | IQELEKQREMQKAAL HHHHHHHHHHHHHHH | 53.04 | 23000965 | |
| 1454 | Ubiquitination | LEKQREMQKAALELL HHHHHHHHHHHHHHH | 27.73 | 21890473 | |
| 1466 | Ubiquitination | ELLSLDLKKRNQEVD HHHHCCHHHHCCCCC | 49.72 | 32015554 | |
| 1467 | Ubiquitination | LLSLDLKKRNQEVDL HHHCCHHHHCCCCCC | 64.97 | - | |
| 1470 | Ubiquitination | LDLKKRNQEVDLQQE CCHHHHCCCCCCCHH | 57.00 | 24816145 | |
| 1484 | Ubiquitination | EQIQELEKCRSVLEH HHHHHHHHHHHHHHH | 47.80 | 29967540 | |
| 1497 | Ubiquitination | EHLPMAVQEREQKLT HHHHHHHHHHHHHHH | 34.20 | 23000965 | |
| 1498 | Ubiquitination | HLPMAVQEREQKLTV HHHHHHHHHHHHHHH | 52.14 | 29967540 | |
| 1500 | Phosphorylation | PMAVQEREQKLTVQR HHHHHHHHHHHHHCH | 51.84 | 32645325 | |
| 1500 | Ubiquitination | PMAVQEREQKLTVQR HHHHHHHHHHHHHCH | 51.84 | 21890473 | |
| 1502 | Ubiquitination | AVQEREQKLTVQREQ HHHHHHHHHHHCHHH | 41.18 | 29967540 | |
| 1504 | Phosphorylation | QEREQKLTVQREQIR HHHHHHHHHCHHHHH | 22.94 | 24719451 | |
| 1508 | Ubiquitination | QKLTVQREQIRELEK HHHHHCHHHHHHHHH | 33.01 | 29967540 | |
| 1512 | Ubiquitination | VQREQIRELEKDRET HCHHHHHHHHHHHHH | 64.01 | 24816145 | |
| 1521 (in isoform 2) | Ubiquitination | - | 42.52 | 21890473 | |
| 1533 | Ubiquitination | HQLLELEKKDQMIES HHHHHHHHHHHHHHH | 74.42 | 29967540 | |
| 1540 | Ubiquitination | KKDQMIESQRGQVQD HHHHHHHHCCCCHHH | 17.79 | 29967540 | |
| 1574 | Ubiquitination | HKMECQQKLIKELEG CHHHHHHHHHHHHHC | 26.71 | 23000965 | |
| 1577 | Ubiquitination | ECQQKLIKELEGQRE HHHHHHHHHHHCCHH | 67.68 | 23000965 | |
| 1577 (in isoform 1) | Ubiquitination | - | 67.68 | 21890473 | |
| 1591 | Ubiquitination | ETQRVALTHLTLDLE HHHHHHHHHHEECHH | 12.71 | 24816145 | |
| 1601 | Phosphorylation | TLDLEERSQELQAQS EECHHHHHHHHHHHH | 31.14 | 22817900 | |
| 1609 | Phosphorylation | QELQAQSSQIHDLES HHHHHHHHHCHHHHH | 22.52 | 22817900 | |
| 1618 | Phosphorylation | IHDLESHSTVLAREL CHHHHHHHHHHHHHH | 29.50 | 22817900 | |
| 1637 | Ubiquitination | QEVKSQREQIEELQR HHHHHHHHHHHHHHH | 48.55 | 24816145 | |
| 1650 | Phosphorylation | QRQKEHLTQDLERRD HHHHHHHHHHHHHHH | 23.19 | 30631047 | |
| 1664 | Ubiquitination | DQELMLQKERIQVLE HHHHHHHHHHHHHHH | 45.02 | 32015554 | |
| 1679 | Ubiquitination | DQRTRQTKILEEDLE HHHHHHHHHHHHHHH | 36.63 | 29967540 | |
| 1689 | Ubiquitination | EEDLEQIKLSLRERG HHHHHHHHHHHHHHH | 31.55 | 29967540 | |
| 1691 | Phosphorylation | DLEQIKLSLRERGRE HHHHHHHHHHHHHHH | 22.00 | 24719451 | |
| 1695 | Ubiquitination | IKLSLRERGRELTTQ HHHHHHHHHHHHHHH | 42.93 | 29967540 | |
| 1700 | Phosphorylation | RERGRELTTQRQLMQ HHHHHHHHHHHHHHH | 19.01 | 25137130 | |
| 1701 | Phosphorylation | ERGRELTTQRQLMQE HHHHHHHHHHHHHHH | 34.09 | - | |
| 1714 | Ubiquitination | QERAEEGKGPSKAQR HHHHHCCCCCCHHHH | 71.56 | 24816145 | |
| 1723 | Phosphorylation | PSKAQRGSLEHMKLI CCHHHHCCHHHHHHH | 32.54 | 20860994 | |
| 1774 | Phosphorylation | GETSLLLSQREQEIV CHHHHHHCHHHHHHH | 27.45 | 24719451 | |
| 1797 | Ubiquitination | AREQGELKEQSLQSQ HHHHCHHHHHHHHHH | 49.78 | 29967540 | |
| 1800 | Phosphorylation | QGELKEQSLQSQLDE HCHHHHHHHHHHHHH | 29.48 | 20873877 | |
| 1803 | Phosphorylation | LKEQSLQSQLDEAQR HHHHHHHHHHHHHHH | 37.69 | 20873877 | |
| 1853 | Phosphorylation | ALEQAHMTLKERHGE HHHHHHHHHHHHCCH | 25.47 | - | |
| 1855 | Ubiquitination | EQAHMTLKERHGELQ HHHHHHHHHHCCHHH | 43.46 | 32015554 | |
| 1865 | Ubiquitination | HGELQDHKEQARRLE CCHHHHHHHHHHHHH | 60.87 | 29967540 | |
| 1901 | Ubiquitination | AESREQEKALLALQQ HCCHHHHHHHHHHHH | 43.99 | 29967540 | |
| 1927 | Phosphorylation | ETRALQDSWLQAQAV HHHHHHHHHHHHHHH | 19.41 | 27251275 | |
| 1936 | Ubiquitination | LQAQAVLKERDQELE HHHHHHHHHHHHHHH | 44.07 | 32015554 | |
| 1972 | Ubiquitination | ALQEALGKAHAALQG HHHHHHHHHHHHHCH | 37.54 | 29967540 | |
| 1980 | Ubiquitination | AHAALQGKEQHLLEQ HHHHHCHHHHHHHHH | 41.04 | 29967540 | |
| 2063 | Ubiquitination | EREQLLEKSLAQRVQ HHHHHHHHHHHHHHH | 51.22 | 29967540 | |
| 2064 | Phosphorylation | REQLLEKSLAQRVQE HHHHHHHHHHHHHHH | 21.40 | - | |
| 2077 | Ubiquitination | QENMIQEKQNLGQER HHHHHHHHHHHCHHH | 28.27 | 29967540 | |
| 2095 | Phosphorylation | EIRGLHQSVRELQLT HHHHHHHHHHHHHHH | 16.64 | 27251275 | |
| 2128 | Phosphorylation | NLEALPHSHKTSPME CHHCCCCCCCCCCHH | 25.41 | 30108239 | |
| 2130 | Ubiquitination | EALPHSHKTSPMEEQ HCCCCCCCCCCHHHH | 54.43 | 29967540 | |
| 2131 | Phosphorylation | ALPHSHKTSPMEEQS CCCCCCCCCCHHHHC | 32.41 | 30108239 | |
| 2132 | Phosphorylation | LPHSHKTSPMEEQSL CCCCCCCCCHHHHCH | 27.36 | 21815630 | |
| 2138 | Phosphorylation | TSPMEEQSLKLDSLE CCCHHHHCHHHHCHH | 30.65 | 30108239 | |
| 2140 | Ubiquitination | PMEEQSLKLDSLEPR CHHHHCHHHHCHHHH | 56.34 | 29967540 | |
| 2143 | Phosphorylation | EQSLKLDSLEPRLQR HHCHHHHCHHHHHHH | 45.10 | - | |
| 2172 | Ubiquitination | REIEWREKAQDLALS HHHHHHHHHHHHHHH | 42.65 | 29967540 | |
| 2179 | Phosphorylation | KAQDLALSLAQTKAS HHHHHHHHHHHHCHH | 18.95 | 29255136 | |
| 2183 | Phosphorylation | LALSLAQTKASVSSL HHHHHHHHCHHHHHH | 23.99 | 29255136 | |
| 2186 | Phosphorylation | SLAQTKASVSSLQEV HHHHHCHHHHHHHHH | 24.88 | 22468782 | |
| 2188 | Phosphorylation | AQTKASVSSLQEVAM HHHCHHHHHHHHHHH | 23.88 | 22468782 | |
| 2189 | Phosphorylation | QTKASVSSLQEVAMF HHCHHHHHHHHHHHH | 31.73 | 28348404 | |
| 2200 | Phosphorylation | VAMFLQASVLERDSE HHHHHHHHHHCCCHH | 17.80 | 22468782 | |
| 2218 | Phosphorylation | LQDELELTRRALEKE HHHHHHHHHHHHHHH | 14.56 | 30001349 | |
| 2229 | Phosphorylation | LEKERLHSPGATSTA HHHHHCCCCCCCCHH | 29.62 | 29255136 | |
| 2233 | Phosphorylation | RLHSPGATSTAELGS HCCCCCCCCHHHCCC | 32.31 | 23401153 | |
| 2234 | Phosphorylation | LHSPGATSTAELGSR CCCCCCCCHHHCCCC | 25.70 | 23927012 | |
| 2235 | Phosphorylation | HSPGATSTAELGSRG CCCCCCCHHHCCCCC | 21.57 | 23927012 | |
| 2240 | Phosphorylation | TSTAELGSRGEQGVQ CCHHHCCCCCCCCCC | 50.14 | 23401153 | |
| 2252 | Phosphorylation | GVQLGEVSGVEAEPS CCCCCCCCCCCCCCC | 32.58 | 30108239 | |
| 2259 | Phosphorylation | SGVEAEPSPDGMEKQ CCCCCCCCCCCHHHH | 27.42 | 30108239 | |
| 2265 | Ubiquitination | PSPDGMEKQSWRQRL CCCCCHHHHHHHHHH | 40.51 | - | |
| 2267 | Phosphorylation | PDGMEKQSWRQRLEH CCCHHHHHHHHHHHH | 34.98 | 30108239 | |
| 2322 | Phosphorylation | MRAAQAGSLEISKAT HHHHHHCCCEEECCC | 26.33 | 29255136 | |
| 2326 | Phosphorylation | QAGSLEISKATASSP HHCCCEEECCCCCCC | 13.58 | 29255136 | |
| 2327 | Ubiquitination | AGSLEISKATASSPT HCCCEEECCCCCCCC | 56.25 | 29967540 | |
| 2329 | Phosphorylation | SLEISKATASSPTQQ CCEEECCCCCCCCCC | 30.70 | 27251275 | |
| 2331 | Phosphorylation | EISKATASSPTQQDG EEECCCCCCCCCCCC | 32.28 | 29255136 | |
| 2332 | Phosphorylation | ISKATASSPTQQDGR EECCCCCCCCCCCCC | 29.51 | 29255136 | |
| 2334 | Phosphorylation | KATASSPTQQDGRGQ CCCCCCCCCCCCCCC | 40.59 | 29255136 | |
| 2347 | Ubiquitination | GQKNSDAKCVAELQK CCCCCCHHHHHHHHH | 33.94 | - | |
| 2364 | Phosphorylation | VLLQAQLTLERKQKQ HHHHHHHHHHHHHHH | 17.94 | - | |
| 2373 | Phosphorylation | ERKQKQDYITRSAQT HHHHHHHHHHHHHHH | 11.16 | 17384208 | |
| 2390 | Phosphorylation | ELAGLHHSLSHSLLA HHHHHHHHHHHHHHH | 22.33 | 24247654 | |
| 2392 | Phosphorylation | AGLHHSLSHSLLAVA HHHHHHHHHHHHHHH | 17.66 | 20708153 | |
| 2394 | Phosphorylation | LHHSLSHSLLAVAQA HHHHHHHHHHHHHCC | 23.00 | 20708153 | |
| 2405 | Phosphorylation | VAQAPEATVLEAETR HHCCCCCCHHHHHHH | 24.78 | 28634298 | |
| 2411 | Phosphorylation | ATVLEAETRRLDESL CCHHHHHHHCCCHHH | 28.30 | 28634298 | |
| 2417 | Phosphorylation | ETRRLDESLTQSLTS HHHCCCHHHHHHCCC | 36.06 | 21076410 | |
| 2419 | Phosphorylation | RRLDESLTQSLTSPG HCCCHHHHHHCCCCC | 25.95 | 30108239 | |
| 2421 | Phosphorylation | LDESLTQSLTSPGPV CCHHHHHHCCCCCCE | 28.51 | 21076410 | |
| 2423 | Phosphorylation | ESLTQSLTSPGPVLL HHHHHHCCCCCCEEE | 37.82 | 25627689 | |
| 2424 | Phosphorylation | SLTQSLTSPGPVLLH HHHHHCCCCCCEEEC | 32.90 | 30108239 | |
| 2433 | Phosphorylation | GPVLLHPSPSTTQAA CCEEECCCCCCCCCC | 22.27 | 30108239 | |
| 2435 | Phosphorylation | VLLHPSPSTTQAASR EEECCCCCCCCCCCC | 48.72 | 26074081 | |
| 2436 | Phosphorylation | LLHPSPSTTQAASR- EECCCCCCCCCCCC- | 26.72 | 26074081 | |
| 2437 | Phosphorylation | LHPSPSTTQAASR-- ECCCCCCCCCCCC-- | 22.13 | 26074081 | |
| 2441 | Phosphorylation | PSTTQAASR------ CCCCCCCCC------ | 41.35 | 26074081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 2392 | S | Phosphorylation | Kinase | SIK2 | Q9H0K1 | GPS |
| 2394 | S | Phosphorylation | Kinase | SIK2 | Q9H0K1 | GPS |
| 2417 | S | Phosphorylation | Kinase | NEK2 | P51955 | Uniprot |
| 2421 | S | Phosphorylation | Kinase | NEK2 | P51955 | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CP250_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CP250_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1048, AND MASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Components of the Hippo pathway cooperate with Nek2 kinase toregulate centrosome disjunction."; Mardin B.R., Lange C., Baxter J.E., Hardy T., Scholz S.R., Fry A.M.,Schiebel E.; Nat. Cell Biol. 12:1166-1176(2010). Cited for: PHOSPHORYLATION AT SER-2417 AND SER-2421. | |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2229 AND SER-2259, ANDMASS SPECTROMETRY. | |
