| UniProt ID | GLT18_HUMAN | |
|---|---|---|
| UniProt AC | Q6P9A2 | |
| Protein Name | Polypeptide N-acetylgalactosaminyltransferase 18 | |
| Gene Name | GALNT18 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 607 | |
| Subcellular Localization |
Golgi apparatus membrane Single-pass type II membrane protein. |
|
| Protein Description | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.. | |
| Protein Sequence | MVCTRKTKTLVSTCVILSGMTNIICLLYVGWVTNYIASVYVRGQEPAPDKKLEEDKGDTLKIIERLDHLENVIKQHIQEAPAKPEEAEAEPFTDSSLFAHWGQELSPEGRRVALKQFQYYGYNAYLSDRLPLDRPLPDLRPSGCRNLSFPDSLPEVSIVFIFVNEALSVLLRSIHSAMERTPPHLLKEIILVDDNSSNEELKEKLTEYVDKVNSQKPGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSFDNIKYDNFEIEEYPLAAQGFDWELWCRYLNPPKAWWKLENSTAPIRSPALIGCFIVDRQYFQEIGLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYTEDLTAHVRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSVYPEMRMYSDIIAYGVLQNSLKTDLCLDQGPDTENVPIMYICHGMTPQNVYYTSSQQIHVGILSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGPIQNRKSKRCLELQENSDLEFGFQLVLQKCSGQHWSITNVLRSLAS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Phosphorylation | TNIICLLYVGWVTNY HHHHHHHHHHHHHHH | - | ||
| 40 | Phosphorylation | TNYIASVYVRGQEPA HHHHHHHHHCCCCCC | - | ||
| 93 | O-linked_Glycosylation | EAEAEPFTDSSLFAH HHCCCCCCCCCHHHH | OGP | ||
| 146 | N-linked_Glycosylation | LRPSGCRNLSFPDSL CCCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 195 | N-linked_Glycosylation | EIILVDDNSSNEELK EEEEECCCCCCHHHH | UniProtKB CARBOHYD | ||
| 237 | Phosphorylation | GLIRSRVSGWRAATA CCCHHHHCCHHHCCC | 24719451 | ||
| 284 | Acetylation | SPSFDNIKYDNFEIE CCCCCCCEECCEEEE | 7480037 | ||
| 284 | Ubiquitination | SPSFDNIKYDNFEIE CCCCCCCEECCEEEE | - | ||
| 320 | N-linked_Glycosylation | KAWWKLENSTAPIRS CHHHCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 453 | Phosphorylation | QCKTFRWYLVSVYPE CCCEEHHHHHHHCHH | - | ||
| 456 | Phosphorylation | TFRWYLVSVYPEMRM EEHHHHHHHCHHHHH | - | ||
| 592 | Phosphorylation | QLVLQKCSGQHWSIT HHHHHHCCCCCCCHH | 29052541 | ||
| 597 | Phosphorylation | KCSGQHWSITNVLRS HCCCCCCCHHHHHHH | 29052541 | ||
| 599 | Phosphorylation | SGQHWSITNVLRSLA CCCCCCHHHHHHHHC | 29052541 | ||
| 604 | Phosphorylation | SITNVLRSLAS---- CHHHHHHHHCC---- | 29052541 | ||
| 607 | Phosphorylation | NVLRSLAS------- HHHHHHCC------- | 29052541 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GLT18_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GLT18_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GLT18_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GLT18_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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