ABR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABR_HUMAN
• UniProt AC: Q12979
• Protein Name: Active breakpoint cluster region-related protein
• Gene Name: ABR
• Organism: Homo sapiens (Human).
• Sequence Length: 859
• Protein Description: GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them..
• Protein Sequence: MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 3)	Phosphorylation	-	55.75	22210691
7 (in isoform 4)	Phosphorylation	-	44.99	29507054
7	Methylation	-MEPLSHRGLPRLSW -CCCCCCCCCCCCCH	44.99	-
11 (in isoform 3)	Phosphorylation	-	46.53	22210691
30 (in isoform 2)	Phosphorylation	-	46.77	25159151
32 (in isoform 2)	Phosphorylation	-	56.82	28348404
33 (in isoform 2)	Phosphorylation	-	52.99	28348404
36 (in isoform 2)	Phosphorylation	-	62.69	28348404
38 (in isoform 2)	Phosphorylation	-	76.34	28348404
53	Phosphorylation	TMPYIDESPTMSPQL CCCCCCCCCCCCCHH	23.17	25849741
55	Phosphorylation	PYIDESPTMSPQLSA CCCCCCCCCCCHHHC	39.29	26471730
57	Phosphorylation	IDESPTMSPQLSARS CCCCCCCCCHHHCCC	16.39	29802988
61	Phosphorylation	PTMSPQLSARSQGGG CCCCCHHHCCCCCCC	19.18	22115753
64	Phosphorylation	SPQLSARSQGGGDGV CCHHHCCCCCCCCCC	32.66	28450419
72	Phosphorylation	QGGGDGVSPTPPEGL CCCCCCCCCCCCCCC	28.69	14205469
74	Phosphorylation	GGDGVSPTPPEGLAP CCCCCCCCCCCCCCC	43.92	26657352
87	Ubiquitination	APGVEAGKGLEMRKL CCCCCCCCCHHHHHH	68.33	-
151	Ubiquitination	QDIYEIHKEFYDNLC HHHHHHHHHHHHHCC	56.00	-
160	Ubiquitination	FYDNLCPKVQQWDSQ HHHHCCHHHHHHHHH	52.24	-
169	Phosphorylation	QQWDSQVTMGHLFQK HHHHHHCHHHHHHHH	15.14	25159151
176	Ubiquitination	TMGHLFQKLASQLGV HHHHHHHHHHHHHCC	38.39	-
185	Ubiquitination	ASQLGVYKAFVDNYK HHHHCCHHHHHCHHH	32.70	-
192	Ubiquitination	KAFVDNYKVALETAE HHHHCHHHHHHHHHH	27.56	-
200	Ubiquitination	VALETAEKCSQSNNQ HHHHHHHHHHHCCHH	36.40	-
210	Ubiquitination	QSNNQFQKISEELKV HCCHHHHHHHHHHCC	49.87	-
216	Ubiquitination	QKISEELKVKGPKDS HHHHHHHCCCCCCCC	45.22	-
223	Phosphorylation	KVKGPKDSKDSHTSV CCCCCCCCCCCCCCE	44.48	24144214
226	Phosphorylation	GPKDSKDSHTSVTME CCCCCCCCCCCEEHH	32.19	24144214
228	Phosphorylation	KDSKDSHTSVTMEAL CCCCCCCCCEEHHHH	28.92	24144214
229	Phosphorylation	DSKDSHTSVTMEALL CCCCCCCCEEHHHHH	15.35	24144214
231	Phosphorylation	KDSHTSVTMEALLYK CCCCCCEEHHHHHCC	14.73	24144214
237	Phosphorylation	VTMEALLYKPIDRVT EEHHHHHCCCCCHHC	18.63	24144214
238	Ubiquitination	TMEALLYKPIDRVTR EHHHHHCCCCCHHCC	35.15	-
244	Phosphorylation	YKPIDRVTRSTLVLH CCCCCHHCCHHHHHH	21.57	22191169
246	Phosphorylation	PIDRVTRSTLVLHDL CCCHHCCHHHHHHHH	19.41	22191179
247	Phosphorylation	IDRVTRSTLVLHDLL CCHHCCHHHHHHHHH	20.00	27251275
264	Phosphorylation	TPVDHPDYPLLQDAL CCCCCCCCHHHHHHH	10.55	22817900
279	Phosphorylation	RISQNFLSSINEDID HHCHHHHHHCCCCCC	25.65	27251275
280	Phosphorylation	ISQNFLSSINEDIDP HCHHHHHHCCCCCCC	31.42	24076635
293	Phosphorylation	DPRRTAVTTPKGETR CCCCCEECCCCCCCC	34.61	24719451
294	Phosphorylation	PRRTAVTTPKGETRQ CCCCEECCCCCCCCH	19.19	24719451
296	Ubiquitination	RTAVTTPKGETRQLV CCEECCCCCCCCHHE	68.25	-
299	Phosphorylation	VTTPKGETRQLVKDG ECCCCCCCCHHEECC	32.17	23312004
336	Phosphorylation	LCAKLKKTSAGKHQQ HHHHCCCCCCCCCCC	23.40	20860994
337	Phosphorylation	CAKLKKTSAGKHQQY HHHCCCCCCCCCCCC	43.85	20860994
366	Phosphorylation	SPEESEASPQVHPFP CHHHCCCCCCCCCCC	16.29	25159151
383	Ubiquitination	ELEDMKMKISALKSE HHHHHHHHHHHHHHH	28.17	-
388	Ubiquitination	KMKISALKSEIQKEK HHHHHHHHHHHHHHH	45.84	-
468	Phosphorylation	DLQAFVLSSVELQVL HHHHHHHHHHHHEEH	27.34	23401153
581	Ubiquitination	YDKTKVNKDNNEIVD CCCCCCCCCCCHHHH	65.89	-
589	Ubiquitination	DNNEIVDKIMGKGQI CCCHHHHHHCCCCEE	24.57	-
593	Ubiquitination	IVDKIMGKGQIQLDP HHHHHCCCCEEEECC	30.20	-
606	Ubiquitination	DPQTVETKNWHTDVI CCCCEEECCCCCCEE	44.53	-
623	Phosphorylation	NGIKVEFSMKFTSRD CCEEEEEEEEEECCC	13.93	24719451
628	Phosphorylation	EFSMKFTSRDMSLKR EEEEEEECCCCCCCC	29.43	25627689
632	Phosphorylation	KFTSRDMSLKRTPSK EEECCCCCCCCCCCC	34.72	25849741
636	Phosphorylation	RDMSLKRTPSKKQTG CCCCCCCCCCCCCCC	30.26	28450419
638	Phosphorylation	MSLKRTPSKKQTGVF CCCCCCCCCCCCCCC	52.45	23401153
640	Ubiquitination	LKRTPSKKQTGVFGV CCCCCCCCCCCCCCE	58.38	-
640	Malonylation	LKRTPSKKQTGVFGV CCCCCCCCCCCCCCE	58.38	26320211
642	Phosphorylation	RTPSKKQTGVFGVKI CCCCCCCCCCCCEEE	44.16	25159151
650	Phosphorylation	GVFGVKISVVTKRER CCCCEEEEEEECCHH	12.57	46157289
653	Phosphorylation	GVKISVVTKRERSKV CEEEEEEECCHHCCC	23.41	29083192
654	Ubiquitination	VKISVVTKRERSKVP EEEEEEECCHHCCCC	40.42	-
659	Malonylation	VTKRERSKVPYIVRQ EECCHHCCCCHHHHH	54.15	26320211
659	Ubiquitination	VTKRERSKVPYIVRQ EECCHHCCCCHHHHH	54.15	-
662	Phosphorylation	RERSKVPYIVRQCVE CHHCCCCHHHHHHHH	18.29	28064214
785	Acetylation	HLKRVAEKEPINKMS HHHHHHHHCCCCHHC	60.08	7396825
785	Ubiquitination	HLKRVAEKEPINKMS HHHHHHHHCCCCHHC	60.08	-
790	Ubiquitination	AEKEPINKMSLHNLA HHHCCCCHHCHHHHH	30.50	-
817	Phosphorylation	VESKAHLTSAADIWS HCCCCCCCCHHHHHC	13.37	24043423
818	Phosphorylation	ESKAHLTSAADIWSH CCCCCCCCHHHHHCH	28.02	24043423
824	Phosphorylation	TSAADIWSHDVMAQV CCHHHHHCHHHHHHH	15.33	24043423
836	Phosphorylation	AQVQVLLYYLQHPPI HHHHHHHHHHHCCCC	9.66	24043423
837	Phosphorylation	QVQVLLYYLQHPPIS HHHHHHHHHHCCCCC	10.39	24043423
844	Phosphorylation	YLQHPPISFAELKRN HHHCCCCCHHHHHCC	24.95	24043423
852	Phosphorylation	FAELKRNTLYFSTDV HHHHHCCEEEEECCC	27.20	27642862
854	Phosphorylation	ELKRNTLYFSTDV-- HHHCCEEEEECCC--	8.08	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.