dbPTM

AKIB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AKIB1_HUMAN
UniProt AC	Q9P2G1
Protein Name	Ankyrin repeat and IBR domain-containing protein 1
Gene Name	ANKIB1
Organism	Homo sapiens (Human).
Sequence Length	1089
Subcellular Localization
Protein Description	Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates..
Protein Sequence	MGNTTTKFRKALINGDENLACQIYENNPQLKESLDPNTSYGEPYQHNTPLHYAARHGMNKILGTFLGRDGNPNKRNVHNETSMHLLCMGPQIMISEGALHPRLARPTEDDFRRADCLQMILKWKGAKLDQGEYERAAIDAVDNKKNTPLHYAAASGMKACVELLVKHGGDLFAENENKDTPCDCAEKQHHKDLALNLESQMVFSRDPEAEEIEAEYAALDKREPYEGLRPQDLRRLKDMLIVETADMLQAPLFTAEALLRAHDWDREKLLEAWMSNPENCCQRSGVQMPTPPPSGYNAWDTLPSPRTPRTTRSSVTSPDEISLSPGDLDTSLCDICMCSISVFEDPVDMPCGHDFCRGCWESFLNLKIQEGEAHNIFCPAYDCFQLVPVDIIESVVSKEMDKRYLQFDIKAFVENNPAIKWCPTPGCDRAVRLTKQGSNTSGSDTLSFPLLRAPAVDCGKGHLFCWECLGEAHEPCDCQTWKNWLQKITEMKPEELVGVSEAYEDAANCLWLLTNSKPCANCKSPIQKNEGCNHMQCAKCKYDFCWICLEEWKKHSSSTGGYYRCTRYEVIQHVEEQSKEMTVEAEKKHKRFQELDRFMHYYTRFKNHEHSYQLEQRLLKTAKEKMEQLSRALKETEGGCPDTTFIEDAVHVLLKTRRILKCSYPYGFFLEPKSTKKEIFELMQTDLEMVTEDLAQKVNRPYLRTPRHKIIKAACLVQQKRQEFLASVARGVAPADSPEAPRRSFAGGTWDWEYLGFASPEEYAEFQYRRRHRQRRRGDVHSLLSNPPDPDEPSESTLDIPEGGSSSRRPGTSVVSSASMSVLHSSSLRDYTPASRSENQDSLQALSSLDEDDPNILLAIQLSLQESGLALDEETRDFLSNEASLGAIGTSLPSRLDSVPRNTDSPRAALSSSELLELGDSLMRLGAENDPFSTDTLSSHPLSEARSDFCPSSSDPDSAGQDPNINDNLLGNIMAWFHDMNPQSIALIPPATTEISADSQLPCIKDGSEGVKDVELVLPEDSMFEDASVSEGRGTQIEENPLEENILAGEAASQAGDSGNEAANRGDGSDVSSQTPQTSSDWLEQVHLV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGNTTTKFR ------CCCCCHHHH	52.04	-
2	Myristoylation	------MGNTTTKFR ------CCCCCHHHH	52.04	20213681
10	Ubiquitination	NTTTKFRKALINGDE CCCHHHHHHHHCCCC	51.15	29967540
24	Phosphorylation	ENLACQIYENNPQLK CCCEEEHHCCCHHHH	6.16	141903
31	Ubiquitination	YENNPQLKESLDPNT HCCCHHHHHCCCCCC	39.76	29967540
38	Phosphorylation	KESLDPNTSYGEPYQ HHCCCCCCCCCCCCC	28.81	28555341
40	Phosphorylation	SLDPNTSYGEPYQHN CCCCCCCCCCCCCCC	24.38	28555341
60	Ubiquitination	AARHGMNKILGTFLG HHHCCHHHHHHHHHC	30.34	29967540
133	Phosphorylation	AKLDQGEYERAAIDA CCCCCCHHHHHHHHH	19.96	24300666
144	Ubiquitination	AIDAVDNKKNTPLHY HHHHHCCCCCCHHHH	42.83	29967540
145	Ubiquitination	IDAVDNKKNTPLHYA HHHHCCCCCCHHHHH	72.77	29967540
166	Ubiquitination	ACVELLVKHGGDLFA HHHHHHHHCCCCCEE	36.18	33845483
188	Ubiquitination	PCDCAEKQHHKDLAL CCCHHHHHHHHHHHH	35.11	27667366
199	Phosphorylation	DLALNLESQMVFSRD HHHHHHHHHHECCCC	27.09	28787133
204	Phosphorylation	LESQMVFSRDPEAEE HHHHHECCCCCCHHH	25.10	28787133
216	Phosphorylation	AEEIEAEYAALDKRE HHHHHHHHHHHHCCC	12.29	28796482
221	Ubiquitination	AEYAALDKREPYEGL HHHHHHHCCCCCCCC	60.56	29967540
284	Phosphorylation	PENCCQRSGVQMPTP HHCHHHCCCCCCCCC	19.89	27732954
290	Phosphorylation	RSGVQMPTPPPSGYN CCCCCCCCCCCCCCC	42.98	27732954
294	Phosphorylation	QMPTPPPSGYNAWDT CCCCCCCCCCCCCCC	60.73	27732954
296	Phosphorylation	PTPPPSGYNAWDTLP CCCCCCCCCCCCCCC	13.17	46163649
301	Phosphorylation	SGYNAWDTLPSPRTP CCCCCCCCCCCCCCC	29.84	27732954
304	Phosphorylation	NAWDTLPSPRTPRTT CCCCCCCCCCCCCCC	30.08	27732954
307	Phosphorylation	DTLPSPRTPRTTRSS CCCCCCCCCCCCCCC	22.10	21592783
362	Phosphorylation	FCRGCWESFLNLKIQ CHHHHHHHHHCCEEC	15.55	63734221
404	Phosphorylation	SKEMDKRYLQFDIKA CHHHHHHHHCCCHHH	15.59	27642862
420	Ubiquitination	VENNPAIKWCPTPGC HHCCCCCEECCCCCC	44.86	29967540
435	Ubiquitination	DRAVRLTKQGSNTSG CHHEEEECCCCCCCC	58.20	30230243
438	Phosphorylation	VRLTKQGSNTSGSDT EEEECCCCCCCCCCC	34.15	22199227
440	Phosphorylation	LTKQGSNTSGSDTLS EECCCCCCCCCCCCC	35.84	22199227
441	Phosphorylation	TKQGSNTSGSDTLSF ECCCCCCCCCCCCCC	40.32	25159151
443	Phosphorylation	QGSNTSGSDTLSFPL CCCCCCCCCCCCCCC	27.47	22199227
445	Phosphorylation	SNTSGSDTLSFPLLR CCCCCCCCCCCCCEE	26.46	23186163
447	Phosphorylation	TSGSDTLSFPLLRAP CCCCCCCCCCCEECC	27.23	23186163
505	Ubiquitination	GVSEAYEDAANCLWL CCHHHHHHHHHHHHH	38.00	27667366
526	Ubiquitination	CANCKSPIQKNEGCN CCCCCCCCCCCCCCC	13.54	27667366
528	Ubiquitination	NCKSPIQKNEGCNHM CCCCCCCCCCCCCCC	58.65	29967540
541	Ubiquitination	HMQCAKCKYDFCWIC CCCCCCCCCCEEEEE	47.34	21906983
554	Ubiquitination	ICLEEWKKHSSSTGG EEHHHHHHHCCCCCC	50.20	29967540
557	Phosphorylation	EEWKKHSSSTGGYYR HHHHHHCCCCCCEEE	31.47	50565235
558	Phosphorylation	EWKKHSSSTGGYYRC HHHHHCCCCCCEEEE	33.80	29457462
559	Phosphorylation	WKKHSSSTGGYYRCT HHHHCCCCCCEEEEE	36.25	46163643
562	Phosphorylation	HSSSTGGYYRCTRYE HCCCCCCEEEEEHHH	6.78	45280653
568	Phosphorylation	GYYRCTRYEVIQHVE CEEEEEHHHHHHHHH	9.08	27642862
587	Ubiquitination	EMTVEAEKKHKRFQE CCCHHHHHHHHHHHH	68.19	33845483
625	Ubiquitination	LLKTAKEKMEQLSRA HHHHHHHHHHHHHHH	47.21	-
634	Ubiquitination	EQLSRALKETEGGCP HHHHHHHHHCCCCCC	62.70	30230243
655	Ubiquitination	DAVHVLLKTRRILKC HHHHHHHHHCHHHCC	35.51	32015554
661	Ubiquitination	LKTRRILKCSYPYGF HHHCHHHCCCCCCCC	20.82	-
663	Phosphorylation	TRRILKCSYPYGFFL HCHHHCCCCCCCCCC	27.79	24708550
664	Phosphorylation	RRILKCSYPYGFFLE CHHHCCCCCCCCCCC	15.22	24708550
666	Phosphorylation	ILKCSYPYGFFLEPK HHCCCCCCCCCCCCC	20.52	24708550
675	Phosphorylation	FFLEPKSTKKEIFEL CCCCCCCCHHHHHHH	52.87	24708550
702	Phosphorylation	AQKVNRPYLRTPRHK HHHCCCCCCCCCHHH	12.94	24114839
712	Ubiquitination	TPRHKIIKAACLVQQ CCHHHHHHHHHHHHH	33.14	29967540
720	Ubiquitination	AACLVQQKRQEFLAS HHHHHHHHHHHHHHH	38.67	21906983
737	Phosphorylation	RGVAPADSPEAPRRS HCCCCCCCCCCCCCC	27.09	19664994
744	Phosphorylation	SPEAPRRSFAGGTWD CCCCCCCCCCCCCCC	22.26	26074081
749	Phosphorylation	RRSFAGGTWDWEYLG CCCCCCCCCCHHHCC	21.23	25072903
754	Phosphorylation	GGTWDWEYLGFASPE CCCCCHHHCCCCCHH	14.10	25072903
759	Phosphorylation	WEYLGFASPEEYAEF HHHCCCCCHHHHHHH	30.50	25072903
763	Phosphorylation	GFASPEEYAEFQYRR CCCCHHHHHHHHHHH	15.12	25072903
768	Phosphorylation	EEYAEFQYRRRHRQR HHHHHHHHHHHHHHH	16.06	25072903
782	Phosphorylation	RRRGDVHSLLSNPPD HHCCCHHHHHCCCCC	30.74	30266825
785	Phosphorylation	GDVHSLLSNPPDPDE CCHHHHHCCCCCCCC	53.21	30266825
794	Phosphorylation	PPDPDEPSESTLDIP CCCCCCCCCCCCCCC	41.97	30266825
796	Phosphorylation	DPDEPSESTLDIPEG CCCCCCCCCCCCCCC	38.31	30266825
797	Phosphorylation	PDEPSESTLDIPEGG CCCCCCCCCCCCCCC	25.13	30266825
805	Phosphorylation	LDIPEGGSSSRRPGT CCCCCCCCCCCCCCC	35.68	26621121
812	Phosphorylation	SSSRRPGTSVVSSAS CCCCCCCCEECCCCH	22.49	24043423
813	Phosphorylation	SSRRPGTSVVSSASM CCCCCCCEECCCCHH	26.83	23312004
816	Phosphorylation	RPGTSVVSSASMSVL CCCCEECCCCHHHHH	20.31	24043423
817	Phosphorylation	PGTSVVSSASMSVLH CCCEECCCCHHHHHH	16.86	24043423
819	Phosphorylation	TSVVSSASMSVLHSS CEECCCCHHHHHHCC	17.34	23312004
821	Phosphorylation	VVSSASMSVLHSSSL ECCCCHHHHHHCCCC	21.02	11722201
825	Phosphorylation	ASMSVLHSSSLRDYT CHHHHHHCCCCCCCC	19.91	11722211
826	Phosphorylation	SMSVLHSSSLRDYTP HHHHHHCCCCCCCCC	23.73	27251275
827	Phosphorylation	MSVLHSSSLRDYTPA HHHHHCCCCCCCCCC	30.36	11722221
863	Phosphorylation	ILLAIQLSLQESGLA HHHHHHHHHHHHCCC	16.19	18088087
880	Phosphorylation	EETRDFLSNEASLGA HHHHHHHHCCCHHHH	32.39	22210691
884	Phosphorylation	DFLSNEASLGAIGTS HHHHCCCHHHHHCCC	22.58	28176443
890	Phosphorylation	ASLGAIGTSLPSRLD CHHHHHCCCCCHHHH	22.45	30266825
891	Phosphorylation	SLGAIGTSLPSRLDS HHHHHCCCCCHHHHC	32.82	30266825
894	Phosphorylation	AIGTSLPSRLDSVPR HHCCCCCHHHHCCCC	51.25	30266825
898	Phosphorylation	SLPSRLDSVPRNTDS CCCHHHHCCCCCCCC	38.32	21815630
903	Phosphorylation	LDSVPRNTDSPRAAL HHCCCCCCCCHHHHC	38.85	22210691
905	Phosphorylation	SVPRNTDSPRAALSS CCCCCCCCHHHHCCH	17.78	22210691
911	Phosphorylation	DSPRAALSSSELLEL CCHHHHCCHHHHHHH	27.39	29255136
912	Phosphorylation	SPRAALSSSELLELG CHHHHCCHHHHHHHH	28.78	29255136
913	Phosphorylation	PRAALSSSELLELGD HHHHCCHHHHHHHHH	28.96	26657352
921	Phosphorylation	ELLELGDSLMRLGAE HHHHHHHHHHHCCCC	23.44	23403867
933	Phosphorylation	GAENDPFSTDTLSSH CCCCCCCCCCCCCCC	30.66	24719451
934	Phosphorylation	AENDPFSTDTLSSHP CCCCCCCCCCCCCCC	33.12	29255136
936	Phosphorylation	NDPFSTDTLSSHPLS CCCCCCCCCCCCCCH	28.73	29255136
938	Phosphorylation	PFSTDTLSSHPLSEA CCCCCCCCCCCCHHH	28.79	29255136
939	Phosphorylation	FSTDTLSSHPLSEAR CCCCCCCCCCCHHHH	32.03	29255136
943	Phosphorylation	TLSSHPLSEARSDFC CCCCCCCHHHHCCCC	33.39	25850435
1012	Ubiquitination	KDGSEGVKDVELVLP CCCCCCEEEEEEECC	67.90	2190698
1053	Phosphorylation	ILAGEAASQAGDSGN CCHHHHHHHHCCCCC	27.84	27499020
1058	Phosphorylation	AASQAGDSGNEAANR HHHHHCCCCCCHHHC	42.47	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AKIB1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AKIB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AKIB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
IMA1_HUMAN	KPNA2	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AKIB1_HUMAN

Related Literatures of Post-Translational Modification

Myristoylation
Reference	PubMed
"Strategy for comprehensive identification of human N-myristoylatedproteins using an insect cell-free protein synthesis system."; Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,Tsunasawa S., Utsumi T.; Proteomics 10:1780-1793(2010). Cited for: MYRISTOYLATION AT GLY-2.	20213681 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, AND MASSSPECTROMETRY.	17081983 [Abstract]