dbPTM

4ET_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	4ET_HUMAN
UniProt AC	Q9NRA8
Protein Name	Eukaryotic translation initiation factor 4E transporter
Gene Name	EIF4ENIF1
Organism	Homo sapiens (Human).
Sequence Length	985
Subcellular Localization	Cytoplasm . Nucleus . Nucleus, PML body . Nucleus speckle . Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription.
Protein Description	Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism..
Protein Sequence	MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDSDGVWDPEKWHASLYPASGRSSPVESLKKELDTDRPSLVRRIVDPRERVKEDDLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRIISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVEVILAQEPAADQEVPRDAVLPEQSPGDFDFNEFFNLDKVPCLASMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKWFGSDVLQQPLPSMPAKVISVDELEYRQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDRRSMGETESG ---CCCCCCCCCCCC	31.84	30266825
6	Sulfoxidation	--MDRRSMGETESGD --CCCCCCCCCCCCC	5.51	21406390
9	Phosphorylation	DRRSMGETESGDAFL CCCCCCCCCCCCCCC	29.71	30266825
11	Phosphorylation	RSMGETESGDAFLDL CCCCCCCCCCCCCCC	49.76	30266825
24	Phosphorylation	DLKKPPASKCPHRYT CCCCCCHHHCCCCCC	40.33	20860994
30	Phosphorylation	ASKCPHRYTKEELLD HHHCCCCCCHHHHHC	21.09	961860221
31	Phosphorylation	SKCPHRYTKEELLDI HHCCCCCCHHHHHCH	31.75	961860211
32	Ubiquitination	KCPHRYTKEELLDIK HCCCCCCHHHHHCHH	40.01	-
39	Ubiquitination	KEELLDIKELPHSKQ HHHHHCHHHCCCCCC	53.52	-
54	Ubiquitination	RPSCLSEKYDSDGVW CCCHHCCCCCCCCCC	51.48	-
55	Phosphorylation	PSCLSEKYDSDGVWD CCHHCCCCCCCCCCC	19.34	28122231
57	Phosphorylation	CLSEKYDSDGVWDPE HHCCCCCCCCCCCHH	32.92	29978859
69	Phosphorylation	DPEKWHASLYPASGR CHHHHEEEECCCCCC	18.62	22115753
71	Phosphorylation	EKWHASLYPASGRSS HHHEEEECCCCCCCC	8.34	22617229
74	Phosphorylation	HASLYPASGRSSPVE EEEECCCCCCCCHHH	30.18	22167270
77	Phosphorylation	LYPASGRSSPVESLK ECCCCCCCCHHHHHH	42.38	25159151
78	Phosphorylation	YPASGRSSPVESLKK CCCCCCCCHHHHHHH	31.44	25159151
82	Phosphorylation	GRSSPVESLKKELDT CCCCHHHHHHHHHCC	45.80	22115753
85	Ubiquitination	SPVESLKKELDTDRP CHHHHHHHHHCCCCH	69.66	-
106	Ubiquitination	VDPRERVKEDDLDVV CCHHHHHCCCCCCEE	62.74	-
115	Phosphorylation	DDLDVVLSPQRRSFG CCCCEEECCCCCCCC	13.84	29255136
120	Phosphorylation	VLSPQRRSFGGGCHV EECCCCCCCCCCCEE	30.36	25159151
128	Phosphorylation	FGGGCHVTAAVSSRR CCCCCEEEEEEECCC	5.80	27080861
132	Phosphorylation	CHVTAAVSSRRSGSP CEEEEEEECCCCCCC	17.25	26434776
133	Phosphorylation	HVTAAVSSRRSGSPL EEEEEEECCCCCCCC	25.72	27080861
136	Phosphorylation	AAVSSRRSGSPLEKD EEEECCCCCCCCCCC	42.38	23401153
138	Phosphorylation	VSSRRSGSPLEKDSD EECCCCCCCCCCCCC	27.79	26055452
144	Phosphorylation	GSPLEKDSDGLRLLG CCCCCCCCCCCEECC	44.65	28122231
157	Phosphorylation	LGGRRIGSGRIISAR CCCEEECCCCEEEEE	23.64	27067055
162	Phosphorylation	IGSGRIISARTFEKD ECCCCEEEEEEECCC	14.88	24719451
173	Phosphorylation	FEKDHRLSDKDLRDL ECCCCCCCHHHHHHH	42.44	26329039
201	Phosphorylation	FRREFGDSKRVFGER HHHHHCCCCHHCCCC	23.81	23401153
202	Acetylation	RREFGDSKRVFGERR HHHHCCCCHHCCCCC	58.27	7662559
213	Phosphorylation	GERRRNDSYTEEEPE CCCCCCCCCCCCCCC	37.19	27273156
214	Phosphorylation	ERRRNDSYTEEEPEW CCCCCCCCCCCCCCH	22.49	30576142
215	Phosphorylation	RRRNDSYTEEEPEWF CCCCCCCCCCCCCHH	40.65	10412051
223	Phosphorylation	EEEPEWFSAGPTSQS CCCCCHHHCCCCCCC	33.13	28450419
227	Phosphorylation	EWFSAGPTSQSETIE CHHHCCCCCCCCEEE	38.18	28450419
228	Phosphorylation	WFSAGPTSQSETIEL HHHCCCCCCCCEEEE	34.54	28102081
230	Phosphorylation	SAGPTSQSETIELTG HCCCCCCCCEEEECC	36.15	28102081
232	Phosphorylation	GPTSQSETIELTGFD CCCCCCCEEEECCCC	25.62	24043423
236	Phosphorylation	QSETIELTGFDDKIL CCCEEEECCCCHHHC	24.02	24043423
248	Acetylation	KILEEDHKGRKRTRR HHCCCHHCCCHHHHH	73.13	25953088
253	Phosphorylation	DHKGRKRTRRRTASV HHCCCHHHHHCCHHH	31.40	159655
257	Phosphorylation	RKRTRRRTASVKEGI CHHHHHCCHHHHHCE	22.82	158023
259	Phosphorylation	RTRRRTASVKEGIVE HHHHCCHHHHHCEEE	32.86	28176443
301	Phosphorylation	DAVLPEQSPGDFDFN CCCCCCCCCCCCCHH	29.23	22617229
321	Phosphorylation	DKVPCLASMIEDVLG CCHHHHHHHHHHHHC	13.82	46204509
331	Phosphorylation	EDVLGEGSVSASRFS HHHHCCCCCCHHHHH	14.48	29978859
333	Phosphorylation	VLGEGSVSASRFSRW HHCCCCCCHHHHHHH	23.40	29978859
335	Phosphorylation	GEGSVSASRFSRWFS CCCCCCHHHHHHHHC	26.76	29978859
338	Phosphorylation	SVSASRFSRWFSNPS CCCHHHHHHHHCCCC	27.73	29978859
342	Phosphorylation	SRFSRWFSNPSRSGS HHHHHHHCCCCCCCC	40.65	28355574
345	Phosphorylation	SRWFSNPSRSGSRSS HHHHCCCCCCCCCCC	43.24	28355574
347	Phosphorylation	WFSNPSRSGSRSSSL HHCCCCCCCCCCCCC	45.52	28450419
349	Phosphorylation	SNPSRSGSRSSSLGS CCCCCCCCCCCCCCC	30.18	28450419
351	Phosphorylation	PSRSGSRSSSLGSTP CCCCCCCCCCCCCCC	26.44	29255136
352	Phosphorylation	SRSGSRSSSLGSTPH CCCCCCCCCCCCCCH	28.59	29255136
353	Phosphorylation	RSGSRSSSLGSTPHE CCCCCCCCCCCCCHH	37.69	23401153
356	Phosphorylation	SRSSSLGSTPHEELE CCCCCCCCCCHHHHH	44.02	23401153
357	Phosphorylation	RSSSLGSTPHEELER CCCCCCCCCHHHHHH	27.20	29255136
374	Phosphorylation	GLEQAILSPGQNSGN CHHHHHCCCCCCCCC	22.37	25159151
374 (in isoform 3)	Phosphorylation	-	22.37	27642862
379	Phosphorylation	ILSPGQNSGNYFAPI HCCCCCCCCCCCCCC	22.11	46204515
382	Phosphorylation	PGQNSGNYFAPIPLE CCCCCCCCCCCCCCH	12.49	30206219
382 (in isoform 3)	Phosphorylation	-	12.49	27642862
404	Ubiquitination	DILEMLQKAKVDLKP CHHHHHHHCCCCHHH	46.33	-
406	Ubiquitination	LEMLQKAKVDLKPLL HHHHHHCCCCHHHHH	43.23	-
410	Sumoylation	QKAKVDLKPLLSSLS HHCCCCHHHHHHHHH	29.20	28112733
410	Ubiquitination	QKAKVDLKPLLSSLS HHCCCCHHHHHHHHH	29.20	-
414	Phosphorylation	VDLKPLLSSLSANKE CCHHHHHHHHHCCHH	36.59	28450419
415	Phosphorylation	DLKPLLSSLSANKEK CHHHHHHHHHCCHHH	26.72	28450419
417	Phosphorylation	KPLLSSLSANKEKLK HHHHHHHHCCHHHHH	31.57	25159151
420	Ubiquitination	LSSLSANKEKLKESS HHHHHCCHHHHHHCC	56.81	-
426	Phosphorylation	NKEKLKESSHSGVVL CHHHHHHCCCCCEEE	31.59	24247654
436 (in isoform 2)	Phosphorylation	-	53.61	28348404
439 (in isoform 2)	Phosphorylation	-	40.06	28348404
443	Ubiquitination	EEVEAGLKGLKVDQQ HHHHHHHCCCCCCHH	62.37	-
446	Ubiquitination	EAGLKGLKVDQQVKN HHHHCCCCCCHHHHC	53.05	-
452	Ubiquitination	LKVDQQVKNSTPFMA CCCCHHHHCCCHHHH	40.62	-
454	Phosphorylation	VDQQVKNSTPFMAEH CCHHHHCCCHHHHHH	31.57	10392647
455	Phosphorylation	DQQVKNSTPFMAEHL CHHHHCCCHHHHHHH	29.91	25159151
465	Phosphorylation	MAEHLEETLSAVTNN HHHHHHHHHHHHHCC	19.35	10392657
467	Phosphorylation	EHLEETLSAVTNNRQ HHHHHHHHHHHCCCH	28.28	10392667
477	Ubiquitination	TNNRQLKKDGDMTAF HCCCHHCCCCCHHHH	75.44	-
482	Phosphorylation	LKKDGDMTAFNKLVS HCCCCCHHHHHHHHH	32.60	20068231
486	Acetylation	GDMTAFNKLVSTMKA CCHHHHHHHHHHHHH	43.76	19608861
486	Ubiquitination	GDMTAFNKLVSTMKA CCHHHHHHHHHHHHH	43.76	19608861
489	Phosphorylation	TAFNKLVSTMKASGT HHHHHHHHHHHHCCC	32.97	20068231
490	Phosphorylation	AFNKLVSTMKASGTL HHHHHHHHHHHCCCC	18.40	20068231
492	Methylation	NKLVSTMKASGTLPS HHHHHHHHHCCCCCC	39.22	-
492	Ubiquitination	NKLVSTMKASGTLPS HHHHHHHHHCCCCCC	39.22	-
494	Phosphorylation	LVSTMKASGTLPSQP HHHHHHHCCCCCCCC	27.13	18691976
496	Phosphorylation	STMKASGTLPSQPKV HHHHHCCCCCCCCCC	32.76	18691976
499	Phosphorylation	KASGTLPSQPKVSRN HHCCCCCCCCCCCCC	63.33	20068231
502	Ubiquitination	GTLPSQPKVSRNLES CCCCCCCCCCCCHHH	45.25	-
504	Phosphorylation	LPSQPKVSRNLESHL CCCCCCCCCCHHHHC	22.90	20068231
509	Phosphorylation	KVSRNLESHLMSPAE CCCCCHHHHCCCCCC	25.70	30266825
513	Phosphorylation	NLESHLMSPAEIPGQ CHHHHCCCCCCCCCC	27.58	30266825
540	Phosphorylation	QPVQRPASSNLLSGL CCCCCCCCCCHHHHH	23.57	25850435
541	Phosphorylation	PVQRPASSNLLSGLM CCCCCCCCCHHHHHH	33.34	21983419
545	Phosphorylation	PASSNLLSGLMGSLE CCCCCHHHHHHCCCC	32.80	25850435
550	Phosphorylation	LLSGLMGSLEPTTSL HHHHHHCCCCCCHHH	18.65	25850435
564	Phosphorylation	LLGQRAPSPPLSQVF HCCCCCCCCCHHHHH	37.86	19664994
568	Phosphorylation	RAPSPPLSQVFQTRA CCCCCCHHHHHHHHH	30.03	30278072
573	Phosphorylation	PLSQVFQTRAASADY CHHHHHHHHHHCCCH	15.71	23927012
574	Methylation	LSQVFQTRAASADYL HHHHHHHHHHCCCHH	19.85	-
577	Phosphorylation	VFQTRAASADYLRPR HHHHHHHCCCHHCCC	22.23	23401153
577 (in isoform 3)	Phosphorylation	-	22.23	27642862
580	Phosphorylation	TRAASADYLRPRIPS HHHHCCCHHCCCCCC	12.34	28796482
580 (in isoform 3)	Phosphorylation	-	12.34	27642862
582	Methylation	AASADYLRPRIPSPI HHCCCHHCCCCCCCC	16.54	-
584	Methylation	SADYLRPRIPSPIGF CCCHHCCCCCCCCCC	47.19	-
587	Phosphorylation	YLRPRIPSPIGFTPG HHCCCCCCCCCCCCC	27.12	29255136
592	Phosphorylation	IPSPIGFTPGPQQLL CCCCCCCCCCHHHHC	23.32	28176443
611	Phosphorylation	QGMRKPMSPITAQMS CCCCCCCCHHHHHHH	22.98	25159151
611 (in isoform 3)	Phosphorylation	-	22.98	28348404
614	Phosphorylation	RKPMSPITAQMSQLE CCCCCHHHHHHHHHH	17.77	45894627
614 (in isoform 3)	Phosphorylation	-	17.77	28348404
618	Phosphorylation	SPITAQMSQLELQQA CHHHHHHHHHHHHHH	21.38	46204527
644	Phosphorylation	AVQAANFYQPGFGKP HHHHHHHCCCCCCCC	17.38	20068231
668	Phosphorylation	RNRQQRVTKSPAPVH HHHHHHCCCCCCCCC	28.17	23927012
670	Phosphorylation	RQQRVTKSPAPVHRG HHHHCCCCCCCCCCC	19.54	23401153
679	Phosphorylation	APVHRGNSSSPAPAA CCCCCCCCCCCCCCC	34.71	21955146
680	Phosphorylation	PVHRGNSSSPAPAAS CCCCCCCCCCCCCCH	44.32	21955146
681	Phosphorylation	VHRGNSSSPAPAASI CCCCCCCCCCCCCHH	25.54	9557983
687	Phosphorylation	SSPAPAASITSMLSP CCCCCCCHHHHHCCC	28.62	21955146
689	Phosphorylation	PAPAASITSMLSPSF CCCCCHHHHHCCCCC	12.94	30206219
690	Phosphorylation	APAASITSMLSPSFT CCCCHHHHHCCCCCC	18.96	21955146
693	Phosphorylation	ASITSMLSPSFTPTS CHHHHHCCCCCCCHH	15.17	25159151
695	Phosphorylation	ITSMLSPSFTPTSVI HHHHCCCCCCCHHHH	38.07	19690332
697	Phosphorylation	SMLSPSFTPTSVIRK HHCCCCCCCHHHHHH	29.96	23403867
699	Phosphorylation	LSPSFTPTSVIRKMY CCCCCCCHHHHHHHH	32.35	23403867
700	Phosphorylation	SPSFTPTSVIRKMYE CCCCCCHHHHHHHHH	19.42	23403867
712	Phosphorylation	MYESKEKSKEEPASG HHHCHHHHCCCCCCC	46.52	23312004
718	Phosphorylation	KSKEEPASGKAALGD HHCCCCCCCCCCCCC	52.09	23312004
726	Phosphorylation	GKAALGDSKEDTQKA CCCCCCCCHHHHHHH	35.83	22912867
730	Phosphorylation	LGDSKEDTQKASEEN CCCCHHHHHHHHHHH	32.82	23312004
732	Ubiquitination	DSKEDTQKASEENLL CCHHHHHHHHHHHCC	56.84	-
734	Phosphorylation	KEDTQKASEENLLSS HHHHHHHHHHHCCCC	53.10	23403867
740	Phosphorylation	ASEENLLSSSSVPSA HHHHHCCCCCCCCCC	31.19	28102081
741	Phosphorylation	SEENLLSSSSVPSAD HHHHCCCCCCCCCCC	26.97	22167270
742	Phosphorylation	EENLLSSSSVPSADR HHHCCCCCCCCCCCC	31.79	22167270
743	Phosphorylation	ENLLSSSSVPSADRD HHCCCCCCCCCCCCC	39.74	22167270
746	Phosphorylation	LSSSSVPSADRDSSP CCCCCCCCCCCCCCC	40.42	23401153
751	Phosphorylation	VPSADRDSSPTTNSK CCCCCCCCCCCCCHH	38.83	22167270
752	Phosphorylation	PSADRDSSPTTNSKL CCCCCCCCCCCCHHH	30.47	22167270
754	Phosphorylation	ADRDSSPTTNSKLSA CCCCCCCCCCHHHHH	40.32	22167270
755	Phosphorylation	DRDSSPTTNSKLSAL CCCCCCCCCHHHHHH	40.66	23401153
757	Phosphorylation	DSSPTTNSKLSALQR CCCCCCCHHHHHHHH	32.64	22167270
758	Ubiquitination	SSPTTNSKLSALQRS CCCCCCHHHHHHHHH	48.83	-
760	Phosphorylation	PTTNSKLSALQRSSC CCCCHHHHHHHHHCC	30.57	26074081
765	Phosphorylation	KLSALQRSSCSTPLS HHHHHHHHCCCCCHH	23.80	29396449
766	Phosphorylation	LSALQRSSCSTPLSQ HHHHHHHCCCCCHHH	17.80	63719951
768	Phosphorylation	ALQRSSCSTPLSQAN HHHHHCCCCCHHHHC	34.70	25850435
769	Phosphorylation	LQRSSCSTPLSQANR HHHHCCCCCHHHHCC	32.35	25159151
772	O-linked_Glycosylation	SSCSTPLSQANRYTK HCCCCCHHHHCCCCC	28.57	31492838
772	Phosphorylation	SSCSTPLSQANRYTK HCCCCCHHHHCCCCC	28.57	29396449
777	Phosphorylation	PLSQANRYTKEQDYR CHHHHCCCCCCCCCC	23.21	26074081
778	Phosphorylation	LSQANRYTKEQDYRP HHHHCCCCCCCCCCC	25.52	26074081
779	Ubiquitination	SQANRYTKEQDYRPK HHHCCCCCCCCCCCC	44.43	-
792	Phosphorylation	PKATGRKTPTLASPV CCCCCCCCCCCCCCC	21.83	29255136
794	Phosphorylation	ATGRKTPTLASPVPT CCCCCCCCCCCCCCC	39.94	29255136
797	Phosphorylation	RKTPTLASPVPTTPF CCCCCCCCCCCCCCC	29.55	27732954
801	Phosphorylation	TLASPVPTTPFLRPV CCCCCCCCCCCCCCC	47.54	27732954
802	Phosphorylation	LASPVPTTPFLRPVH CCCCCCCCCCCCCCC	13.13	27732954
891	Phosphorylation	LLNPRPGTPLHLAMV CCCCCCCCHHHHHHH	25.92	25850435
905	Phosphorylation	VQQQLQRSVLHPPGS HHHHHHHHCCCCCCC	18.97	28555341
912	Phosphorylation	SVLHPPGSGSHAAAV HCCCCCCCCCCEEEE	42.78	21712546
914	O-linked_Glycosylation	LHPPGSGSHAAAVSV CCCCCCCCCEEEEEE	16.20	31492838
914	Phosphorylation	LHPPGSGSHAAAVSV CCCCCCCCCEEEEEE	16.20	22817900
920	Phosphorylation	GSHAAAVSVQTTPQN CCCEEEEEEECCCCC	12.09	22817900
923	Phosphorylation	AAAVSVQTTPQNVPS EEEEEEECCCCCCCC	37.98	21712546
924	Phosphorylation	AAVSVQTTPQNVPSR EEEEEECCCCCCCCC	13.04	24541691
939	Phosphorylation	SGLPHMHSQLEHRPS CCCCCHHHHCCCCCC	28.96	27080861
946	Phosphorylation	SQLEHRPSQRSSSPV HHCCCCCCCCCCCCC	37.88	30838647
948	Methylation	LEHRPSQRSSSPVGL CCCCCCCCCCCCCHH	42.73	-
949	Phosphorylation	EHRPSQRSSSPVGLA CCCCCCCCCCCCHHH	27.77	30266825
950	Phosphorylation	HRPSQRSSSPVGLAK CCCCCCCCCCCHHHH	40.63	30266825
951	Phosphorylation	RPSQRSSSPVGLAKW CCCCCCCCCCHHHHH	25.50	25159151
961	Phosphorylation	GLAKWFGSDVLQQPL HHHHHHCCCHHHCCC	18.31	26074081
970	Phosphorylation	VLQQPLPSMPAKVIS HHHCCCCCCCCEEEE	45.11	24719451
977	Phosphorylation	SMPAKVISVDELEYR CCCCEEEEHHHCCCC	26.88	101664433
983	Phosphorylation	ISVDELEYRQ----- EEHHHCCCCC-----	100.00	7582705

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
301	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
374	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
513	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
587	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
693	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
752	S	Phosphorylation	Kinase	MAPK8	P45983	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of 4ET_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of 4ET_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF4E_HUMAN	EIF4E	physical	10856257
FPPS_HUMAN	FDPS	physical	19060904
DTX2_HUMAN	DTX2	physical	25416956
EFHC1_HUMAN	EFHC1	physical	25416956
MGT5B_HUMAN	MGAT5B	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
MARF1_HUMAN	KIAA0430	physical	27173435
NISCH_HUMAN	NISCH	physical	27173435
PAN2_HUMAN	PAN2	physical	27173435
PCGF5_HUMAN	PCGF5	physical	27173435
CBP_HUMAN	CREBBP	physical	27173435
K1671_HUMAN	KIAA1671	physical	27173435
PCGF3_HUMAN	PCGF3	physical	27173435
ARI3A_HUMAN	ARID3A	physical	27173435
ERF_HUMAN	ERF	physical	27173435
NUP50_HUMAN	NUP50	physical	27173435
CO039_HUMAN	C15orf39	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of 4ET_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-486, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-564; SER-587;SER-693 AND SER-951, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-564, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-136; SER-138;SER-345; SER-564 AND SER-951, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-914 AND SER-920, ANDMASS SPECTROMETRY.	18088087 [Abstract]