CO039_HUMAN - dbPTM
CO039_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CO039_HUMAN
UniProt AC Q6ZRI6
Protein Name Uncharacterized protein C15orf39
Gene Name C15orf39
Organism Homo sapiens (Human).
Sequence Length 1047
Subcellular Localization
Protein Description
Protein Sequence MAEKRPLRTLGPVMYGKLPRLETDSGLEHSLPHSVGNQDPCTYKGSYFSCPMAGTPKAESEQLASWTPYPPLYSTGMAGPPLQADNLLTNCLFYRSPAEGPEKMQDSSPVELLPFSPQAHSYPGPPLAAPKPVYRNPLCYGLSTCLGEGAVKRPLDVDWTLATGPLLPSADPPCSLAPAPSKGQTLDGTFLRGVPAEGSSKDSSGSFSPCQPFLEKYQTIHSTGFLASRYTGPYPRNSKQAMSEGPSSPWTQLAQPLGPPCQDTGPTHYPPPHHPPPHPPQALPCPPACRHPEKQGSYSPALPLQPLGGHKGTGYQAGGLGSPYLRQQAAQAPYIPPLGLDAYPYPSAPLPAPSPGLKLEPPLTPRCPLDFAPQTLSFPYARDDLSLYGASPGLGGTPPSQNNVRAVPQPGAFQRACQPLPASQPCSEPVRPAQEAEEKTWLPSCRKEKLQPRLSEHSGPPIVIRDSPVPCTPPALPPCARECQSLPQKEGARPPSSPPMPVIDNVFSLAPYRDYLDVPAPEATTEPDSATAEPDSAPATSEGQDKGCRGTLPAQEGPSGSKPLRGSLKEEVALDLSVRKPTAEASPVKASRSVEHAKPTAAMDVPDVGNMVSDLPGLKKIDTEAPGLPGVPVTTDAMPRTNFHSSVAFMFRKFKILRPAPLPAAVVPSTPTSAPAPTQPAPTPTSGPIGLRILAQQPLSVTCFSLALPSPPAVAVASPAPAPAPSPAPARAQAPASARDPAPAPAPVAGPAPASTSAPGDSLEQHFTGLHASLCDAISGSVAHSPPEKLREWLETAGPWGQAAWQDCQGVQGLLAKLLSQLQRFDRTHRCPFPHVVRAGAIFVPIHLVKERLFPRLPPASVDHVLQEHRVELRPTTLSEERALRELALPGCTSRMLKLLALRQLPDIYPDLLGLQWRDCVRRQLGDFDTEAGAVSSSEPTVARGEPESLALAQKSPAPKVRKPGRKPPTPGPEKAEAAAGEESCGASPTPATSASPPGPTLKARFRSLLETAWLNGLALPTWGHKSSRPDQPSPCPQLLDSQSHHL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17SumoylationLGPVMYGKLPRLETD
CCHHHCCCCCCEECC		37.52-
17AcetylationLGPVMYGKLPRLETD
CCHHHCCCCCCEECC		37.5219608861
17UbiquitinationLGPVMYGKLPRLETD
CCHHHCCCCCCEECC		37.5219608861
17SumoylationLGPVMYGKLPRLETD
CCHHHCCCCCCEECC		37.5219608861
23PhosphorylationGKLPRLETDSGLEHS
CCCCCEECCCCCCCC		39.8022210691
30PhosphorylationTDSGLEHSLPHSVGN
CCCCCCCCCCCCCCC		33.9322210691
34O-linked_GlycosylationLEHSLPHSVGNQDPC
CCCCCCCCCCCCCCC		29.7630059200
42PhosphorylationVGNQDPCTYKGSYFS
CCCCCCCCCCCCEEE		33.3922210691
44UbiquitinationNQDPCTYKGSYFSCP
CCCCCCCCCCEEECC		24.19-
55PhosphorylationFSCPMAGTPKAESEQ
EECCCCCCCCHHHHH		16.4528985074
57SumoylationCPMAGTPKAESEQLA
CCCCCCCCHHHHHHH		65.70-
107PhosphorylationGPEKMQDSSPVELLP
CCCCCCCCCCCEECC		21.4625159151
108PhosphorylationPEKMQDSSPVELLPF
CCCCCCCCCCEECCC		41.0520068231
116PhosphorylationPVELLPFSPQAHSYP
CCEECCCCCCCCCCC		17.7320068231
121PhosphorylationPFSPQAHSYPGPPLA
CCCCCCCCCCCCCCC		35.7226074081
122PhosphorylationFSPQAHSYPGPPLAA
CCCCCCCCCCCCCCC		11.4426074081
152AcetylationCLGEGAVKRPLDVDW
HCCCCCCCCCCCCCC		48.0020167786
192MethylationTLDGTFLRGVPAEGS
CCCCCEECCCCCCCC		39.61-
201UbiquitinationVPAEGSSKDSSGSFS
CCCCCCCCCCCCCCC		64.4321963094
203PhosphorylationAEGSSKDSSGSFSPC
CCCCCCCCCCCCCCC		40.0925394399
204PhosphorylationEGSSKDSSGSFSPCQ
CCCCCCCCCCCCCCH		48.9023401153
206PhosphorylationSSKDSSGSFSPCQPF
CCCCCCCCCCCCHHH		25.2129255136
208PhosphorylationKDSSGSFSPCQPFLE
CCCCCCCCCCHHHHH		26.8529255136
229MethylationSTGFLASRYTGPYPR
HHCCHHHCCCCCCCC		27.68-
294UbiquitinationPACRHPEKQGSYSPA
CCCCCCCCCCCCCCC		65.4929967540
297PhosphorylationRHPEKQGSYSPALPL
CCCCCCCCCCCCCCC		21.6823401153
298PhosphorylationHPEKQGSYSPALPLQ
CCCCCCCCCCCCCCC		26.0422167270
299PhosphorylationPEKQGSYSPALPLQP
CCCCCCCCCCCCCCC		12.8522167270
311UbiquitinationLQPLGGHKGTGYQAG
CCCCCCCCCCCCCCC		62.5329967540
313PhosphorylationPLGGHKGTGYQAGGL
CCCCCCCCCCCCCCC		37.2027080861
322PhosphorylationYQAGGLGSPYLRQQA
CCCCCCCCHHHHHHH		18.5325159151
324PhosphorylationAGGLGSPYLRQQAAQ
CCCCCCHHHHHHHHH		19.0627080861
343PhosphorylationPPLGLDAYPYPSAPL
CCCCCCCCCCCCCCC		11.7227080861
345PhosphorylationLGLDAYPYPSAPLPA
CCCCCCCCCCCCCCC		9.3529978859
347PhosphorylationLDAYPYPSAPLPAPS
CCCCCCCCCCCCCCC		36.3529978859
354PhosphorylationSAPLPAPSPGLKLEP
CCCCCCCCCCCCCCC		33.4329978859
364PhosphorylationLKLEPPLTPRCPLDF
CCCCCCCCCCCCCCC		17.9226074081
366MethylationLEPPLTPRCPLDFAP
CCCCCCCCCCCCCCC		29.47-
386PhosphorylationPYARDDLSLYGASPG
CCCCCCHHHCCCCCC		26.9221712546
388PhosphorylationARDDLSLYGASPGLG
CCCCHHHCCCCCCCC		13.7929214152
391PhosphorylationDLSLYGASPGLGGTP
CHHHCCCCCCCCCCC		18.3525159151
397PhosphorylationASPGLGGTPPSQNNV
CCCCCCCCCCCCCCC		30.1725159151
400PhosphorylationGLGGTPPSQNNVRAV
CCCCCCCCCCCCCCC		46.9020068231
455PhosphorylationEKLQPRLSEHSGPPI
HHHCHHHHHCCCCCE		34.2521712546
458PhosphorylationQPRLSEHSGPPIVIR
CHHHHHCCCCCEEEC		49.2823898821
467PhosphorylationPPIVIRDSPVPCTPP
CCEEECCCCCCCCCC		20.2525159151
472PhosphorylationRDSPVPCTPPALPPC
CCCCCCCCCCCCCCC		26.6625159151
485PhosphorylationPCARECQSLPQKEGA
CCHHHHHCCCHHCCC		54.3925159151
496PhosphorylationKEGARPPSSPPMPVI
HCCCCCCCCCCCCEE		59.1525106551
497PhosphorylationEGARPPSSPPMPVID
CCCCCCCCCCCCEEC		38.5025106551
561PhosphorylationAQEGPSGSKPLRGSL
CCCCCCCCCCCCCCC		35.1224719451
562UbiquitinationQEGPSGSKPLRGSLK
CCCCCCCCCCCCCCC		52.1529967540
562AcetylationQEGPSGSKPLRGSLK
CCCCCCCCCCCCCCC		52.1523954790
577PhosphorylationEEVALDLSVRKPTAE
HHHHEECCCCCCCCC		21.3928102081
582PhosphorylationDLSVRKPTAEASPVK
ECCCCCCCCCCCCCC		39.9225159151
586PhosphorylationRKPTAEASPVKASRS
CCCCCCCCCCCCCCC		23.0225159151
591PhosphorylationEASPVKASRSVEHAK
CCCCCCCCCCCCCCC		21.2626074081
591O-linked_GlycosylationEASPVKASRSVEHAK
CCCCCCCCCCCCCCC		21.2630059200
598UbiquitinationSRSVEHAKPTAAMDV
CCCCCCCCCCCCCCC		44.82-
598AcetylationSRSVEHAKPTAAMDV
CCCCCCCCCCCCCCC		44.8226051181
619UbiquitinationVSDLPGLKKIDTEAP
HHCCCCCCCCCCCCC		54.3129967540
619AcetylationVSDLPGLKKIDTEAP
HHCCCCCCCCCCCCC		54.3125953088
620UbiquitinationSDLPGLKKIDTEAPG
HCCCCCCCCCCCCCC		51.35-
620SumoylationSDLPGLKKIDTEAPG
HCCCCCCCCCCCCCC		51.35-
620SumoylationSDLPGLKKIDTEAPG
HCCCCCCCCCCCCCC		51.35-
634O-linked_GlycosylationGLPGVPVTTDAMPRT
CCCCCCCCCCCCCCC		16.9430059200
635O-linked_GlycosylationLPGVPVTTDAMPRTN
CCCCCCCCCCCCCCC		23.2230059200
670PhosphorylationPAAVVPSTPTSAPAP
CCEECCCCCCCCCCC		25.2321712546
683PhosphorylationAPTQPAPTPTSGPIG
CCCCCCCCCCCCCCH		41.1121712546
702PhosphorylationAQQPLSVTCFSLALP
ECCCCEEEEEEECCC		12.4028102081
705PhosphorylationPLSVTCFSLALPSPP
CCEEEEEEECCCCCC		18.1928348404
710PhosphorylationCFSLALPSPPAVAVA
EEEECCCCCCEEEEC		44.3528348404
718PhosphorylationPPAVAVASPAPAPAP
CCEEEECCCCCCCCC		18.2628102081
726PhosphorylationPAPAPAPSPAPARAQ
CCCCCCCCCCCCCCC		35.4828348404
789UbiquitinationVAHSPPEKLREWLET
CCCCCHHHHHHHHHH		59.6329967540
828PhosphorylationQLQRFDRTHRCPFPH
HHHHHCCCCCCCCCC		18.6023403867
850UbiquitinationFVPIHLVKERLFPRL
EEEHHHHHHHHCCCC		43.4021963094
894PhosphorylationLALPGCTSRMLKLLA
HCCCCHHHHHHHHHH		21.55-
898AcetylationGCTSRMLKLLALRQL
CHHHHHHHHHHHHCC		31.9226051181
898 (in isoform 1)Ubiquitination-31.9221890473
898 (in isoform 2)Ubiquitination-31.9221890473
898UbiquitinationGCTSRMLKLLALRQL
CHHHHHHHHHHHHCC		31.9223000965
935 (in isoform 2)Phosphorylation-5.8120068231
936PhosphorylationDTEAGAVSSSEPTVA
CCCCCCCCCCCCCCC		27.84-
956PhosphorylationSLALAQKSPAPKVRK
HHHHHHCCCCCCCCC		17.7623186163
970PhosphorylationKPGRKPPTPGPEKAE
CCCCCCCCCCHHHHH		49.7823401153
984PhosphorylationEAAAGEESCGASPTP
HHHCCCCCCCCCCCC		17.3527732954
988PhosphorylationGEESCGASPTPATSA
CCCCCCCCCCCCCCC		18.0025159151
990PhosphorylationESCGASPTPATSASP
CCCCCCCCCCCCCCC		24.0627732954
993PhosphorylationGASPTPATSASPPGP
CCCCCCCCCCCCCCH		26.4827732954
994PhosphorylationASPTPATSASPPGPT
CCCCCCCCCCCCCHH		28.9327732954
996PhosphorylationPTPATSASPPGPTLK
CCCCCCCCCCCHHHH		31.2525850435
1001PhosphorylationSASPPGPTLKARFRS
CCCCCCHHHHHHHHH		46.9727732954
1034PhosphorylationSSRPDQPSPCPQLLD
CCCCCCCCCCCHHHC		33.2424247654
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CO039_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CO039_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CO039_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
CTBP2_HUMANCTBP2physical
21988832
MARF1_HUMANKIAA0430physical
27173435
PAN2_HUMANPAN2physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CO039_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-17, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208; SER-391 ANDTHR-397, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, AND MASSSPECTROMETRY.

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