| UniProt ID | CTBP2_HUMAN | |
|---|---|---|
| UniProt AC | P56545 | |
| Protein Name | C-terminal-binding protein 2 | |
| Gene Name | CTBP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 445 | |
| Subcellular Localization | Nucleus . Cell junction, synapse. | |
| Protein Description | Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).; Isoform 2 probably acts as a scaffold for specialized synapses.. | |
| Protein Sequence | MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPAAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Acetylation | --MALVDKHKVKRQR --CCCCCHHHHHHHH | 37.53 | 27452117 | |
| 6 | Ubiquitination | --MALVDKHKVKRQR --CCCCCHHHHHHHH | 37.53 | 33845483 | |
| 6 | Malonylation | --MALVDKHKVKRQR --CCCCCHHHHHHHH | 37.53 | 32601280 | |
| 8 | Acetylation | MALVDKHKVKRQRLD CCCCCHHHHHHHHHH | 56.01 | 16356938 | |
| 8 | Ubiquitination | MALVDKHKVKRQRLD CCCCCHHHHHHHHHH | 56.01 | 24816145 | |
| 10 | Acetylation | LVDKHKVKRQRLDRI CCCHHHHHHHHHHHH | 47.84 | 16356938 | |
| 22 | Asymmetric dimethylarginine | DRICEGIRPQIMNGP HHHHHCCCHHHHCCC | 28.11 | - | |
| 22 | Methylation | DRICEGIRPQIMNGP HHHHHCCCHHHHCCC | 28.11 | 24129315 | |
| 33 | Methylation | MNGPLHPRPLVALLD HCCCCCCCCEEEEEC | 26.83 | - | |
| 44 | Glutathionylation | ALLDGRDCTVEMPIL EEECCCCCEEECCHH | 4.41 | 22555962 | |
| 52 | Ubiquitination | TVEMPILKDLATVAF EEECCHHHHHHHHHH | 51.95 | 32015554 | |
| 60 | Glutathionylation | DLATVAFCDAQSTQE HHHHHHHCCCCCHHH | 2.82 | 22555962 | |
| 69 | Ubiquitination | AQSTQEIHEKVLNEA CCCHHHHHHHHHHHH | 28.24 | 24816145 | |
| 82 | Phosphorylation | EAVGAMMYHTITLTR HHHHHHHHHHEEECH | 5.24 | 20068231 | |
| 84 | Phosphorylation | VGAMMYHTITLTRED HHHHHHHHEEECHHH | 9.73 | 20068231 | |
| 86 | Phosphorylation | AMMYHTITLTREDLE HHHHHHEEECHHHHH | 24.19 | 22210691 | |
| 88 | Phosphorylation | MYHTITLTREDLEKF HHHHEEECHHHHHHH | 24.30 | 22210691 | |
| 94 (in isoform 2) | Phosphorylation | - | 60.50 | - | |
| 94 | Ubiquitination | LTREDLEKFKALRVI ECHHHHHHHHHCEEE | 60.50 | 24816145 | |
| 100 (in isoform 2) | Phosphorylation | - | 5.02 | - | |
| 106 | Phosphorylation | RVIVRIGSGYDNVDI EEEEECCCCCCCCCC | 31.63 | 28348404 | |
| 108 | Phosphorylation | IVRIGSGYDNVDIKA EEECCCCCCCCCCEE | 13.17 | - | |
| 120 | Ubiquitination | IKAAGELGIAVCNIP CEECCCCEEEEECCC | 11.08 | 32015554 | |
| 153 | Phosphorylation | YRRNTWLYQALREGT HHCCCHHHHHHHCCC | 5.36 | 28152594 | |
| 162 | Ubiquitination | ALREGTRVQSVEQIR HHHCCCCCCCHHHHH | 5.09 | 24816145 | |
| 164 | Phosphorylation | REGTRVQSVEQIREV HCCCCCCCHHHHHHH | 25.43 | 12872159 | |
| 179 (in isoform 2) | Phosphorylation | - | 31.20 | 17525332 | |
| 179 | Phosphorylation | ASGAARIRGETLGLI HHHCCHHCCCEEEEE | 31.20 | 17525332 | |
| 181 | Phosphorylation | GAARIRGETLGLIGF HCCHHCCCEEEEEEE | 30.89 | 17525332 | |
| 181 (in isoform 2) | Phosphorylation | - | 30.89 | 17525332 | |
| 185 | Phosphorylation | IRGETLGLIGFGRTG HCCCEEEEEEECCCC | 3.78 | 17525332 | |
| 185 (in isoform 2) | Phosphorylation | - | 3.78 | 17525332 | |
| 196 (in isoform 2) | Phosphorylation | - | 6.52 | - | |
| 198 (in isoform 2) | Phosphorylation | - | 22.19 | - | |
| 205 | Phosphorylation | RAKAFGFSVIFYDPY HHHHHCEEEEEECHH | 18.06 | 28450419 | |
| 209 | Phosphorylation | FGFSVIFYDPYLQDG HCEEEEEECHHHHCH | 12.60 | 28450419 | |
| 212 | Phosphorylation | SVIFYDPYLQDGIER EEEEECHHHHCHHHH | 17.69 | 28450419 | |
| 254 | Ubiquitination | EHNHHLINDFTIKQM CCCCCCCCCCCHHHH | 44.71 | 23000965 | |
| 257 (in isoform 2) | Phosphorylation | - | 30.08 | - | |
| 261 | Ubiquitination | NDFTIKQMRQGAFLV CCCCHHHHHCCCCHH | 2.68 | 23000965 | |
| 266 (in isoform 2) | Phosphorylation | - | 11.35 | - | |
| 270 (in isoform 2) | Phosphorylation | - | 7.34 | - | |
| 279 (in isoform 1) | Ubiquitination | - | 44.21 | 21890473 | |
| 279 | Ubiquitination | RGGLVDEKALAQALK CCCCCCHHHHHHHHH | 44.21 | 23000965 | |
| 279 | Acetylation | RGGLVDEKALAQALK CCCCCCHHHHHHHHH | 44.21 | 25953088 | |
| 279 | Malonylation | RGGLVDEKALAQALK CCCCCCHHHHHHHHH | 44.21 | 26320211 | |
| 286 (in isoform 1) | Ubiquitination | - | 62.23 | 21890473 | |
| 286 | Ubiquitination | KALAQALKEGRIRGA HHHHHHHHHCCCCCE | 62.23 | 23000965 | |
| 286 | Acetylation | KALAQALKEGRIRGA HHHHHHHHHCCCCCE | 62.23 | 25953088 | |
| 291 | Methylation | ALKEGRIRGAALDVH HHHHCCCCCEEECCC | 27.60 | - | |
| 347 | Ubiquitination | EIRRAITGRIPESLR HHHHHHHCCCCHHHH | 21.29 | 23000965 | |
| 352 | Phosphorylation | ITGRIPESLRNCVNK HHCCCCHHHHHHCCC | 27.55 | 20068231 | |
| 354 | Ubiquitination | GRIPESLRNCVNKEF CCCCHHHHHHCCCCC | 43.72 | 23000965 | |
| 354 | Ubiquitination | GRIPESLRNCVNKEF CCCCHHHHHHCCCCC | 43.72 | 21890473 | |
| 364 | Phosphorylation | VNKEFFVTSAPWSVI CCCCCEEECCCCCEE | 17.64 | 26657352 | |
| 365 | Phosphorylation | NKEFFVTSAPWSVID CCCCEEECCCCCEEC | 27.34 | 28450419 | |
| 369 | Phosphorylation | FVTSAPWSVIDQQAI EEECCCCCEECHHHC | 14.24 | 29496963 | |
| 384 | Phosphorylation | HPELNGATYRYPPGI CHHHCCCEEECCCCE | 15.21 | 25850435 | |
| 385 | Phosphorylation | PELNGATYRYPPGIV HHHCCCEEECCCCEE | 13.96 | 25850435 | |
| 387 | Phosphorylation | LNGATYRYPPGIVGV HCCCEEECCCCEEEE | 11.90 | 24732914 | |
| 414 | Phosphorylation | IPGGIPVTHNLPTVA CCCCCCCCCCCCCCC | 10.33 | 26846344 | |
| 419 | Phosphorylation | PVTHNLPTVAHPSQA CCCCCCCCCCCCCCC | 33.23 | 26846344 | |
| 424 | Phosphorylation | LPTVAHPSQAPSPNQ CCCCCCCCCCCCCCC | 29.16 | 26846344 | |
| 428 | Phosphorylation | AHPSQAPSPNQPTKH CCCCCCCCCCCCCCC | 39.23 | 26846344 | |
| 433 | Phosphorylation | APSPNQPTKHGDNRE CCCCCCCCCCCCCCC | 26.38 | 26846344 | |
| 592 | Ubiquitination | ---------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------- | 32015554 | ||
| 634 | Ubiquitination | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | 24816145 | ||
| 819 | Ubiquitination | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | 23000965 | ||
| 819 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 826 | Ubiquitination | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | 23000965 | ||
| 826 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 905 | Phosphorylation | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | 32142685 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 164 | S | Phosphorylation | Kinase | PKACA | P17612 | PSP |
| 164 | S | Phosphorylation | Kinase | PAK6 | Q9NQU5 | PSP |
| 428 | S | Phosphorylation | Kinase | HIPK2 | Q9H2X6 | PSP |
| - | K | Ubiquitination | E3 ubiquitin ligase | STUB1 | Q9UNE7 | PMID:23410750 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CTBP2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CTBP2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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