ZN750_HUMAN - dbPTM
ZN750_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN750_HUMAN
UniProt AC Q32MQ0
Protein Name Zinc finger protein 750
Gene Name ZNF750
Organism Homo sapiens (Human).
Sequence Length 723
Subcellular Localization Nucleus .
Protein Description Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression..
Protein Sequence MSLLKERKPKKPHYIPRPPGKPFKYKCFQCPFTCNEKSHLFNHMKYGLCKNSITLVSEQDRVPKCPKSNSLDPKQTNQPDATAKPASSKSVANGLSAFDSKLQHSSAREDIKENLELQARGTHRCLGQKPALHRASPCKSPAPEAALGAQPALEGAARPSAFVPVGEHRLKGPDNAEAPETLALHNPTAKAVSFHTKSAFHTPGYPWKAGSPFLPPEFPHKISSTKGLGAISPYMHPTIPEYPPHFYTEHGLATIYSPYLLAGSSPECDAPLLSVYGTQDPRHFLPHPGPIPKHLAPSPATYDHYRFFQQYPSNLPIPYGFYRPESAFSSYGLRLPPVTGLTRDQSSHLLEEATLVYPASSPSRLNPSDPNRKHVEFESPIPEAKDSSKAGQRDTEGSKMSPRAGSAATGSPGRPSPTDFMQTSQTCEGLYDLSNKAASSALGRLYPPEQSLTAFRPVKKSTECLPAQAAETTAESPVSLNVVNGDPPAPTGSASLVSEAAPSSPDDSSGMGPLNLSKKSEINLAATHEPTYQGSPQAETASFSELQDLPLNLSVKDPCNTQAPRPAFPGRPRAAEPAAAVPQKTGTEGSEDGPSHPETKPGSLDGDGAPPTGPGEEAPDACAVDSSEEQKQTAAVALCQLAAYSPRNIRVGDGDAAAPEPACRQDTPTLSSMESQEAQCDLRPKGQKRTSLRDAGKSQQGAKKAKLQDTARVFTLRRRARVS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSLLKERKP
------CCCCCCCCC		42.2724719451
136PhosphorylationKPALHRASPCKSPAP
CCCHHCCCCCCCCCH		30.6828348404
140PhosphorylationHRASPCKSPAPEAAL
HCCCCCCCCCHHHHH		32.7730242111
354PhosphorylationSHLLEEATLVYPASS
CHHHCEEEEEEECCC		21.75-
357PhosphorylationLEEATLVYPASSPSR
HCEEEEEEECCCHHH		9.0122817900
360PhosphorylationATLVYPASSPSRLNP
EEEEEECCCHHHCCC		37.9724719451
361PhosphorylationTLVYPASSPSRLNPS
EEEEECCCHHHCCCC		29.0628348404
368PhosphorylationSPSRLNPSDPNRKHV
CHHHCCCCCCCCCCC		65.70-
379PhosphorylationRKHVEFESPIPEAKD
CCCCCCCCCCCCCCC		33.1924719451
395PhosphorylationSKAGQRDTEGSKMSP
CCCCCCCCCCCCCCC		44.4227251275
401PhosphorylationDTEGSKMSPRAGSAA
CCCCCCCCCCCCCCC		18.2524719451
406PhosphorylationKMSPRAGSAATGSPG
CCCCCCCCCCCCCCC		17.4728102081
409PhosphorylationPRAGSAATGSPGRPS
CCCCCCCCCCCCCCC		37.6024719451
411PhosphorylationAGSAATGSPGRPSPT
CCCCCCCCCCCCCCC		21.5928348404
416PhosphorylationTGSPGRPSPTDFMQT
CCCCCCCCCCCHHHH		38.7933259812
418PhosphorylationSPGRPSPTDFMQTSQ
CCCCCCCCCHHHHHH		46.3228348404
423PhosphorylationSPTDFMQTSQTCEGL
CCCCHHHHHHHHHHH		15.8328102081
424PhosphorylationPTDFMQTSQTCEGLY
CCCHHHHHHHHHHHH		13.4428102081
426PhosphorylationDFMQTSQTCEGLYDL
CHHHHHHHHHHHHHH		16.5828102081
431PhosphorylationSQTCEGLYDLSNKAA
HHHHHHHHHHCHHHH		26.2028102081
535PhosphorylationHEPTYQGSPQAETAS
CCCCCCCCCCCCCCC		9.7928348404
540PhosphorylationQGSPQAETASFSELQ
CCCCCCCCCCHHHHH		30.5328348404
542PhosphorylationSPQAETASFSELQDL
CCCCCCCCHHHHHCC		36.4028348404
544PhosphorylationQAETASFSELQDLPL
CCCCCCHHHHHCCCC		34.6028348404
645PhosphorylationLCQLAAYSPRNIRVG
HHHHHHHCCCCEECC		16.8022617229
667PhosphorylationEPACRQDTPTLSSME
CCHHCCCCCCCHHHH		15.1628348404
715PhosphorylationQDTARVFTLRRRARV
HHHHHHHHHHHHHCC		19.2524719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN750_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN750_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN750_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZN750_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
610227Seborrhea-like dermatitis with psoriasiform elements (SLDP)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN750_HUMAN

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Related Literatures of Post-Translational Modification

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