TEAD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEAD3_HUMAN
• UniProt AC: Q99594
• Protein Name: Transcriptional enhancer factor TEF-5
• Gene Name: TEAD3
• Organism: Homo sapiens (Human).
• Sequence Length: 435
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer..
• Protein Sequence: MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASNSWNAS ------CCCCCCCCC	19.88	21406692
3	Phosphorylation	-----MASNSWNASS -----CCCCCCCCCC	30.05	28450419
5	Phosphorylation	---MASNSWNASSSP ---CCCCCCCCCCCC	21.15	28450419
9	Phosphorylation	ASNSWNASSSPGEAR CCCCCCCCCCCCCCC	28.30	22167270
10	Phosphorylation	SNSWNASSSPGEARE CCCCCCCCCCCCCCC	37.83	22167270
11	Phosphorylation	NSWNASSSPGEARED CCCCCCCCCCCCCCC	34.13	28355574
36	Phosphorylation	NDAEGVWSPDIEQSF CCCCCCCCCCHHHHH	15.41	-
57	Ubiquitination	YPPCGRRKIILSDEG CCCCCCCEEEECCCC	32.51	29967540
61	Phosphorylation	GRRKIILSDEGKMYG CCCEEEECCCCCEEC	24.17	30266825
65	Ubiquitination	IILSDEGKMYGRNEL EEECCCCCEECHHHH	27.22	23000965
76	Phosphorylation	RNELIARYIKLRTGK HHHHHHHHHHHHCCC	8.06	21403953
83	Methylation	YIKLRTGKTRTRKQV HHHHHCCCCCCHHHH	33.93	-
88	Ubiquitination	TGKTRTRKQVSSHIQ CCCCCCHHHHHHHHH	55.21	-
119	Acetylation	MNLDQVSKDKALQSM CCHHHHCHHHHHHHH	65.47	26051181
128	Phosphorylation	KALQSMASMSSAQIV HHHHHHHHCCHHHHH	15.57	22964224
130	Phosphorylation	LQSMASMSSAQIVSA HHHHHHCCHHHHHCH	21.74	22964224
131	Phosphorylation	QSMASMSSAQIVSAS HHHHHCCHHHHHCHH	18.62	22964224
145	Phosphorylation	SVLQNKFSPPSPLPQ HHHCCCCCCCCCCCC	37.19	30266825
148	Phosphorylation	QNKFSPPSPLPQAVF CCCCCCCCCCCCHHH	42.31	30266825
156	Phosphorylation	PLPQAVFSTSSRFWS CCCCHHHCCCCCCCC	22.30	30266825
156	O-linked_Glycosylation	PLPQAVFSTSSRFWS CCCCHHHCCCCCCCC	22.30	30059200
157	Phosphorylation	LPQAVFSTSSRFWSS CCCHHHCCCCCCCCC	21.18	30266825
158	Phosphorylation	PQAVFSTSSRFWSSP CCHHHCCCCCCCCCC	20.51	30266825
159	Phosphorylation	QAVFSTSSRFWSSPP CHHHCCCCCCCCCCC	31.42	30266825
163	Phosphorylation	STSSRFWSSPPLLGQ CCCCCCCCCCCCCCC	30.20	25627689
164	Phosphorylation	TSSRFWSSPPLLGQQ CCCCCCCCCCCCCCC	22.57	25627689
175	Phosphorylation	LGQQPGPSQDIKPFA CCCCCCCCCCCCCCC	46.53	-
231	Phosphorylation	RLRLLEYSAFMEVQR HHHHHHHHHHEEECC	12.98	22617229
272	Phosphorylation	AVDVRQIYDKFPEKK ECCHHHHHHHCCHHC	12.54	-
274	Ubiquitination	DVRQIYDKFPEKKGG CHHHHHHHCCHHCCC	45.94	-
279	Acetylation	YDKFPEKKGGLKELY HHHCCHHCCCHHHHH	57.45	18528607
283	Acetylation	PEKKGGLKELYEKGP CHHCCCHHHHHHHCC	49.28	18528615
337	Phosphorylation	SVSTKVCSFGKQVVE EEEEEECCCCHHHHH	39.77	24719451
340	Ubiquitination	TKVCSFGKQVVEKVE EEECCCCHHHHHHHH	37.60	32142685
348	Phosphorylation	QVVEKVETEYARLEN HHHHHHHHHEEEHHC	36.96	28152594
350	Phosphorylation	VEKVETEYARLENGR HHHHHHHEEEHHCCE	12.39	24719451
402	Phosphorylation	TILQVVTSRDSQETL EEEEEEECCCCHHHE	23.60	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEAD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEAD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEAD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WWTR1_HUMAN	WWTR1	physical	16189514
VGLL2_HUMAN	VGLL2	physical	25416956
CHIP_HUMAN	STUB1	physical	24366813
FAS_HUMAN	FASN	physical	24366813
GTPB8_HUMAN	GTPBP8	physical	24366813
HSP74_HUMAN	HSPA4	physical	24366813
MCMBP_HUMAN	MCMBP	physical	24366813
ODPA_HUMAN	PDHA1	physical	24366813
YAP1_HUMAN	YAP1	physical	24366813

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.