GTPB8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GTPB8_HUMAN
• UniProt AC: Q8N3Z3
• Protein Name: GTP-binding protein 8
• Gene Name: GTPBP8
• Organism: Homo sapiens (Human).
• Sequence Length: 284
• Protein Sequence: MAAPGLRLGAGRLFEMPAVLERLSRYNSTSQAFAEVLRLPKQQLRKLLYPLQEVERFLAPYGRQDLHLRIFDPSPEDIARADNIFTATERNRIDYVSSAVRIDHAPDLPRPEVCFIGRSNVGKSSLIKALFSLAPEVEVRVSKKPGHTKKMNFFKVGKHFTVVDMPGYGFRAPEDFVDMVETYLKERRNLKRTFLLVDSVVGIQKTDNIAIEMCEEFALPYVIVLTKIDKSSKGHLLKQVLQIQKFVNMKTQGCFPQLFPVSAVTFSGIHLLRCFIASVTGSLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	VLERLSRYNSTSQAF HHHHHHCCCCHHHHH	15.30	22468782
28	Phosphorylation	ERLSRYNSTSQAFAE HHHHCCCCHHHHHHH	22.09	22468782
41	Ubiquitination	AEVLRLPKQQLRKLL HHHHCCCHHHHHHHH	56.09	-
46	Ubiquitination	LPKQQLRKLLYPLQE CCHHHHHHHHHHHHH	51.98	-
74	Phosphorylation	HLRIFDPSPEDIARA EEEEECCCHHHHHHH	42.64	19664994
125	Phosphorylation	RSNVGKSSLIKALFS CCCCCHHHHHHHHHH	37.28	24719451
278	Phosphorylation	LLRCFIASVTGSLD- HHHHHHHHHHCCCC-	18.52	-
280	Phosphorylation	RCFIASVTGSLD--- HHHHHHHHCCCC---	20.68	-
282	Phosphorylation	FIASVTGSLD----- HHHHHHCCCC-----	21.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GTPB8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GTPB8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GTPB8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
AMGO3_HUMAN	AMIGO3	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
LAMP2_HUMAN	LAMP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.