AMGO3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AMGO3_HUMAN
• UniProt AC: Q86WK7
• Protein Name: Amphoterin-induced protein 3
• Gene Name: AMIGO3 {ECO:0000312|EMBL:AAO48944.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 504
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity)..
• Protein Sequence: MTWLVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAREYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYCNTSVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQTHEYNVSVHFPRPEPEAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCRRWPQTPSPLQELSAQSSVLSTTPPDAPSRKASVHKHVVFLEPGRRGLNGRVQLAVAEEFDLYNPGGLQLKAGSESASSIGSEGPMTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	MLRVGLGTPDSEGFP HHHHCCCCCCCCCCC	29.03	23663014
23	Phosphorylation	VGLGTPDSEGFPPRA HCCCCCCCCCCCHHH	40.60	23663014
107	N-linked_Glycosylation	LGRGVFVNASGLRLL HCCCEEECCCCCEEE	19.54	UniProtKB CARBOHYD
117	Phosphorylation	GLRLLDLSSNTLRAL CCEEEECCHHHHHHC	22.62	27732954
118	Phosphorylation	LRLLDLSSNTLRALG CEEEECCHHHHHHCC	40.92	27732954
120	Phosphorylation	LLDLSSNTLRALGRH EEECCHHHHHHCCCC	21.40	27732954
137	Acetylation	DGLGALEKLLLFNNR CHHHHHHHHHHCCCE	45.33	7695407
272	N-linked_Glycosylation	QHSRVFENCSSAPAL ECCHHCCCCCCCCCC	21.36	UniProtKB CARBOHYD
295	Phosphorylation	LYALVGRSLRLYCNT HHHHHHCHHHHHHCC	16.35	24719451
301	N-linked_Glycosylation	RSLRLYCNTSVPAMR CHHHHHHCCCCCCCE	23.10	UniProtKB CARBOHYD
324	Phosphorylation	ELLRAPGSRDGSIAV HHHCCCCCCCCCEEE	26.58	24719451
362	N-linked_Glycosylation	TGPRLHHNQTHEYNV CCCCCCCCCCEEEEE	37.38	UniProtKB CARBOHYD
368	N-linked_Glycosylation	HNQTHEYNVSVHFPR CCCCEEEEEEEECCC	19.32	UniProtKB CARBOHYD
449	Phosphorylation	DAPSRKASVHKHVVF CCCCCCCEECEEEEE	27.99	24719451
490	Phosphorylation	GLQLKAGSESASSIG CCEEECCCCCCCCCC	32.98	68698503
492	Phosphorylation	QLKAGSESASSIGSE EEECCCCCCCCCCCC	34.84	68698509
494	Phosphorylation	KAGSESASSIGSEGP ECCCCCCCCCCCCCC	31.59	68698515

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AMGO3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AMGO3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AMGO3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMGO1_HUMAN	AMIGO1	physical	12629050
AMGO2_HUMAN	AMIGO2	physical	12629050
AMGO3_HUMAN	AMIGO3	physical	12629050
TM268_HUMAN	C9orf91	physical	28514442
GOLP3_HUMAN	GOLPH3	physical	28514442
C1QL4_HUMAN	C1QL4	physical	28514442
FBX2_HUMAN	FBXO2	physical	28514442
SE1L1_HUMAN	SEL1L	physical	28514442
UFSP2_HUMAN	UFSP2	physical	28514442
CALX_HUMAN	CANX	physical	28514442
S22AI_HUMAN	SLC22A18	physical	28514442
OMA1_HUMAN	OMA1	physical	28514442
ZDH17_HUMAN	ZDHHC17	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.