GOLP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GOLP3_HUMAN
• UniProt AC: Q9H4A6
• Protein Name: Golgi phosphoprotein 3
• Gene Name: GOLPH3
• Organism: Homo sapiens (Human).
• Sequence Length: 298
• Subcellular Localization: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Cell membrane. Endosome. Phosphatid
• Protein Description: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis..
• Protein Sequence: MTSLTQRSSGLVQRRTEASRNAADKERAAGGGAGSSEDDAQSRRDEQDDDDKGDSKETRLTLMEEVLLLGLKDREGYTSFWNDCISSGLRGCMLIELALRGRLQLEACGMRRKSLLTRKVICKSDAPTGDVLLDEALKHVKETQPPETVQNWIELLSGETWNPLKLHYQLRNVRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLTNNNIKQRLIKKVQEAVLDKWVNDPHRMDRRLLALIYLAHASDVLENAFAPLLDEQYDLATKRVRQLLDLDPEVECLKANTNEVLWAVVAAFTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSLTQRSS ------CCCCHHHHH	32.23	28464451
3	Phosphorylation	-----MTSLTQRSSG -----CCCCHHHHHC	28.28	26074081
5	Phosphorylation	---MTSLTQRSSGLV ---CCCCHHHHHCHH	23.00	26074081
8	Phosphorylation	MTSLTQRSSGLVQRR CCCCHHHHHCHHHHH	20.95	25159151
9	Phosphorylation	TSLTQRSSGLVQRRT CCCHHHHHCHHHHHH	38.03	28464451
16	Phosphorylation	SGLVQRRTEASRNAA HCHHHHHHHHHHHHH	37.78	26074081
35	Phosphorylation	AAGGGAGSSEDDAQS HCCCCCCCCHHHHHH	29.98	23401153
36	Phosphorylation	AGGGAGSSEDDAQSR CCCCCCCCHHHHHHH	44.09	23401153
42	Phosphorylation	SSEDDAQSRRDEQDD CCHHHHHHHHHCCCC	30.88	28985074
52	Ubiquitination	DEQDDDDKGDSKETR HCCCCCCCCCCHHHH	72.16	22817900
56	Ubiquitination	DDDKGDSKETRLTLM CCCCCCCHHHHHHHH	68.77	21906983
99	Ubiquitination	CMLIELALRGRLQLE HHHHHHHHHCCHHHH	10.49	21890473
110	Sulfoxidation	LQLEACGMRRKSLLT HHHHHCCCCCHHHHH	3.63	21406390
114	Phosphorylation	ACGMRRKSLLTRKVI HCCCCCHHHHHCCEE	27.14	24719451
117	Phosphorylation	MRRKSLLTRKVICKS CCCHHHHHCCEEECC	33.46	23909892
123	Ubiquitination	LTRKVICKSDAPTGD HHCCEEECCCCCCCC	40.00	32015554
138	Ubiquitination	VLLDEALKHVKETQP HHHHHHHHHHHHHCC	54.09	32015554
143	Phosphorylation	ALKHVKETQPPETVQ HHHHHHHHCCCHHHH	40.43	-
148	Phosphorylation	KETQPPETVQNWIEL HHHCCCHHHHHHHHH	32.92	-
168	Phosphorylation	WNPLKLHYQLRNVRE CCHHHHHHHHHHHHH	21.48	-
179	Ubiquitination	NVRERLAKNLVEKGV HHHHHHHHHHHHCCC	56.24	-
184	Ubiquitination	LAKNLVEKGVLTTEK HHHHHHHCCCCCCCC	47.00	29967540
191	Ubiquitination	KGVLTTEKQNFLLFD CCCCCCCCCCEEEEE	48.74	22817900
216	Ubiquitination	IKQRLIKKVQEAVLD HHHHHHHHHHHHHHH	42.00	29967540
224	Acetylation	VQEAVLDKWVNDPHR HHHHHHHHHCCCHHH	49.21	27452117
280	S-nitrosylation	DLDPEVECLKANTNE CCCCCCCHHHCCHHH	5.96	19483679
280	S-nitrosocysteine	DLDPEVECLKANTNE CCCCCCCHHHCCHHH	5.96	-
298	Ubiquitination	AVVAAFTK------- HHHHHHCC-------	52.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
143	T	Phosphorylation	Kinase	PRKDC	P78527	GPS
148	T	Phosphorylation	Kinase	PRKDC	P78527	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GOLP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GOLP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMPPB_HUMAN	GMPPB	physical	26186194
GMPPA_HUMAN	GMPPA	physical	26186194
RCC1L_HUMAN	WBSCR16	physical	26186194
XYLK_HUMAN	FAM20B	physical	26186194
TSR3_HUMAN	TSR3	physical	26186194
AIMP1_HUMAN	AIMP1	physical	26344197
DCNL1_HUMAN	DCUN1D1	physical	26344197
PFD4_HUMAN	PFDN4	physical	26344197
PFD5_HUMAN	PFDN5	physical	26344197
RUVB2_HUMAN	RUVBL2	physical	26344197
SPEE_HUMAN	SRM	physical	26344197
TIPRL_HUMAN	TIPRL	physical	26344197
PFD3_HUMAN	VBP1	physical	26344197
RCC1L_HUMAN	WBSCR16	physical	28514442
GMPPA_HUMAN	GMPPA	physical	28514442
GMPPB_HUMAN	GMPPB	physical	28514442
TSR3_HUMAN	TSR3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.