TSR3_HUMAN - dbPTM
TSR3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TSR3_HUMAN
UniProt AC Q9UJK0
Protein Name Ribosome biogenesis protein TSR3 homolog {ECO:0000255|HAMAP-Rule:MF_03146}
Gene Name TSR3 {ECO:0000255|HAMAP-Rule:MF_03146}
Organism Homo sapiens (Human).
Sequence Length 312
Subcellular Localization
Protein Description Probable pre-rRNA processing protein involved in ribosome biogenesis..
Protein Sequence MGRRRAARGPGAEGGRPRHLPTRSLEAFAEEVGAALQASVEPGAADGEGGPGPAALPCTLAMWELGHCDPRRCTGRKLARLGLVRCLRLGHRFGGLVLSPVGKQYASPADRQLVAQSGVAVIDCSWARLDETPFGKMRGSHLRLLPYLVAANPVNYGRPYRLSCVEAFAATFCIVGFPDLAVILLRKFKWGKGFLDLNRQLLDKYAACGSPEEVLQAEQEFLANAKESPQEEEIDPFDVDSGREFGNPNRPVASTRLPSDTDDSDASEDPGPGAERGGASSSCCEEEQTQGRGAEARAPAEVWKGIKKRQRD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8MethylationMGRRRAARGPGAEGG
CCCCCCCCCCCCCCC		51.35115919077
24PhosphorylationPRHLPTRSLEAFAEE
CCCCCCHHHHHHHHH		32.80-
99PhosphorylationRFGGLVLSPVGKQYA
HCCCEEEECCCHHCC		15.2929214152
103UbiquitinationLVLSPVGKQYASPAD
EEEECCCHHCCCHHH		40.1323000965
132PhosphorylationSWARLDETPFGKMRG
CCCCCCCCCCCCCCC		24.4721815630
136AcetylationLDETPFGKMRGSHLR
CCCCCCCCCCCCHHH		26.2925953088
136UbiquitinationLDETPFGKMRGSHLR
CCCCCCCCCCCCHHH		26.2922817900
147PhosphorylationSHLRLLPYLVAANPV
CHHHHHHHHHHCCCC		17.4922817900
156PhosphorylationVAANPVNYGRPYRLS
HHCCCCCCCCCCHHH		18.10-
160PhosphorylationPVNYGRPYRLSCVEA
CCCCCCCCHHHHHHH		23.87-
187UbiquitinationLAVILLRKFKWGKGF
HHHHHHHHCCCCCCH		51.7922817900
189UbiquitinationVILLRKFKWGKGFLD
HHHHHHCCCCCCHHH		59.0622817900
192UbiquitinationLRKFKWGKGFLDLNR
HHHCCCCCCHHHHHH		45.4322817900
204UbiquitinationLNRQLLDKYAACGSP
HHHHHHHHHHHCCCH		36.4429967540
210PhosphorylationDKYAACGSPEEVLQA
HHHHHCCCHHHHHHH		29.0828122231
228PhosphorylationFLANAKESPQEEEID
HHHCCCCCCCCCCCC		31.0425159151
241PhosphorylationIDPFDVDSGREFGNP
CCCCCCCCCCCCCCC		39.3325159151
254PhosphorylationNPNRPVASTRLPSDT
CCCCCCCCCCCCCCC		17.8120363803
255PhosphorylationPNRPVASTRLPSDTD
CCCCCCCCCCCCCCC		26.8723927012
259PhosphorylationVASTRLPSDTDDSDA
CCCCCCCCCCCCCCC		58.7023927012
261PhosphorylationSTRLPSDTDDSDASE
CCCCCCCCCCCCCCC		46.1523927012
264PhosphorylationLPSDTDDSDASEDPG
CCCCCCCCCCCCCCC		37.5823927012
267PhosphorylationDTDDSDASEDPGPGA
CCCCCCCCCCCCCCC		47.7423927012
280PhosphorylationGAERGGASSSCCEEE
CCCCCCCCHHHCHHH		26.5123663014
281PhosphorylationAERGGASSSCCEEEQ
CCCCCCCHHHCHHHH		27.1929255136
282PhosphorylationERGGASSSCCEEEQT
CCCCCCHHHCHHHHH		21.9429255136
289PhosphorylationSCCEEEQTQGRGAEA
HHCHHHHHCCCCCHH		35.9528102081
304UbiquitinationRAPAEVWKGIKKRQR
HCCHHHHHHHHHHHC		56.8029967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TSR3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TSR3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TSR3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TSR3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TSR3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259; THR-261; SER-264AND SER-267, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259; THR-261; SER-264;SER-267 AND SER-282, AND MASS SPECTROMETRY.

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