dbPTM

PFD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PFD4_HUMAN
UniProt AC	Q9NQP4
Protein Name	Prefoldin subunit 4
Gene Name	PFDN4
Organism	Homo sapiens (Human).
Sequence Length	134
Subcellular Localization	Nucleus . Cytoplasm . Mitochondrion .
Protein Description	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins..
Protein Sequence	MAATMKKAAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQRVLADLKVQLYAKFGSNINLEADES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAATMKKAA ------CCCHHHHHH	16.19	22814378
4	Phosphorylation	----MAATMKKAAAE ----CCCHHHHHHHH	21.71	-
6	Ubiquitination	--MAATMKKAAAEDV --CCCHHHHHHHHHC	34.60	22817900
7	Ubiquitination	-MAATMKKAAAEDVN -CCCHHHHHHHHHCC	32.22	22817900
31	Phosphorylation	NKFARNTSRITELKE HHHHHCCHHHHHHHH	25.82	25159151
37	Ubiquitination	TSRITELKEEIEVKK CHHHHHHHHHHHHHH	47.25	33845483
43	2-Hydroxyisobutyrylation	LKEEIEVKKKQLQNL HHHHHHHHHHHHCCH	41.27	-
92	Ubiquitination	EMLEEAKKNLQEEID HHHHHHHHHHHHHHH	70.68	29967540
103	Phosphorylation	EEIDALESRVESIQR HHHHHHHHHHHHHHH	42.34	21712546
125	Phosphorylation	QLYAKFGSNINLEAD HHHHHCCCCCCCCCC	37.36	26846344
134	Phosphorylation	INLEADES------- CCCCCCCC-------	46.17	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PFD4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PFD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PFD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PFD5_HUMAN	PFDN5	physical	22939629
PFD6_HUMAN	PFDN6	physical	22939629
PFD3_HUMAN	VBP1	physical	25416956
IF6_HUMAN	EIF6	physical	26344197
FLNA_HUMAN	FLNA	physical	26344197
GFPT1_HUMAN	GFPT1	physical	26344197
MSH2_HUMAN	MSH2	physical	26344197
PFD1_HUMAN	PFDN1	physical	26344197
PFD2_HUMAN	PFDN2	physical	26344197
PFD5_HUMAN	PFDN5	physical	26344197
PFD6_HUMAN	PFDN6	physical	26344197
PPM1G_HUMAN	PPM1G	physical	26344197
TRUA_HUMAN	PUS1	physical	26344197
SIL1_HUMAN	SIL1	physical	26344197
SLMAP_HUMAN	SLMAP	physical	26344197
PFD3_HUMAN	VBP1	physical	26344197
RUSD2_HUMAN	RPUSD2	physical	28514442
PFD3_HUMAN	VBP1	physical	28514442
PFD2_HUMAN	PFDN2	physical	28514442
KTNB1_HUMAN	KATNB1	physical	28514442
PFD5_HUMAN	PFDN5	physical	28514442
PFD1_HUMAN	PFDN1	physical	28514442
RC3H2_HUMAN	RC3H2	physical	28514442
KTNA1_HUMAN	KATNA1	physical	28514442
PFD6_HUMAN	PFDN6	physical	28514442
SPI2B_HUMAN	SPIN2B	physical	28514442
ERCC8_HUMAN	ERCC8	physical	28514442
ATF2_HUMAN	ATF2	physical	28514442
MFR1L_HUMAN	MTFR1L	physical	28514442
MIO_HUMAN	MIOS	physical	28514442
FBX28_HUMAN	FBXO28	physical	28514442
BANP_HUMAN	BANP	physical	28514442
SPIN3_HUMAN	SPIN3	physical	28514442
NEDD1_HUMAN	NEDD1	physical	28514442
TRAF7_HUMAN	TRAF7	physical	28514442
ZZZ3_HUMAN	ZZZ3	physical	28514442
CTU2_HUMAN	CTU2	physical	28514442
PDRG1_HUMAN	PDRG1	physical	28514442
KAISO_HUMAN	ZBTB33	physical	28514442
CREB1_HUMAN	CREB1	physical	28514442
UBB_HUMAN	UBB	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PFD4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, AND MASSSPECTROMETRY.	18669648 [Abstract]