SPI2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPI2B_HUMAN
• UniProt AC: Q9BPZ2
• Protein Name: Spindlin-2B
• Gene Name: SPIN2B
• Organism: Homo sapiens (Human).
• Sequence Length: 258
• Subcellular Localization: Nucleus .
• Protein Description: Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors. [PubMed: 12145692 Exhibits H3K4me3-binding activity]
• Protein Sequence: MKTPNAQEAEGQQTRAAAGRATGSANMTKKKVSQKKQRGRPSSQPRRNIVGCRISHGWKEGDEPITQWKGTVLDQVPINPSLYLVKYDGIDCVYGLELHRDERVLSLKILSDRVASSHISDANLANTIIGKAVEHMFEGEHGSKDEWRGMVLAQAPIMKAWFYITYEKDPVLYMYQLLDDYKEGDLRIMPESSESPPTEREPGGVVDGLIGKHVEYTKEDGSKRIGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MKTPNAQEA ------CCCCCHHHH	73.09	-
3	Phosphorylation	-----MKTPNAQEAE -----CCCCCHHHHC	22.07	21815630
3	O-linked_Glycosylation	-----MKTPNAQEAE -----CCCCCHHHHC	22.07	30620550
14	Phosphorylation	QEAEGQQTRAAAGRA HHHCCHHHHHHHHHC	17.87	24043423
35	Acetylation	TKKKVSQKKQRGRPS CHHHHHHHHHCCCCC	43.28	11565435
36	Acetylation	KKKVSQKKQRGRPSS HHHHHHHHHCCCCCC	37.28	11565443
87	Phosphorylation	PSLYLVKYDGIDCVY CCEEEEEECCCCEEE	16.36	-
94	Phosphorylation	YDGIDCVYGLELHRD ECCCCEEEEEEECCC	23.48	-
106	Phosphorylation	HRDERVLSLKILSDR CCCCCEEEEEECHHH	25.43	24719451
108	Ubiquitination	DERVLSLKILSDRVA CCCEEEEEECHHHHH	37.92	21890473
116	Phosphorylation	ILSDRVASSHISDAN ECHHHHHHCCCCHHH	21.42	20068231
117	Phosphorylation	LSDRVASSHISDANL CHHHHHHCCCCHHHH	18.33	20068231
120	Phosphorylation	RVASSHISDANLANT HHHHCCCCHHHHHHH	25.83	20068231
127	Phosphorylation	SDANLANTIIGKAVE CHHHHHHHHHHHHHH	14.36	20068231
143	Phosphorylation	MFEGEHGSKDEWRGM HHCCCCCCCCHHHCE	38.55	-
144	Ubiquitination	FEGEHGSKDEWRGMV HCCCCCCCCHHHCEE	65.35	-
182	Ubiquitination	YQLLDDYKEGDLRIM EEECHHHHCCCEEEC	63.31	-
192	Phosphorylation	DLRIMPESSESPPTE CEEECCCCCCCCCCC	33.27	27732954
193	Phosphorylation	LRIMPESSESPPTER EEECCCCCCCCCCCC	40.19	24719451
195	Phosphorylation	IMPESSESPPTEREP ECCCCCCCCCCCCCC	37.82	21815630
198	Phosphorylation	ESSESPPTEREPGGV CCCCCCCCCCCCCCC	51.57	27732954
212	Ubiquitination	VVDGLIGKHVEYTKE CCCCCCEEEEEEECC	37.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPI2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPI2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPI2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPIN1_HUMAN	SPIN1	physical	26186194
XPC_HUMAN	XPC	physical	26186194
WDHD1_HUMAN	WDHD1	physical	26186194
SP16H_HUMAN	SUPT16H	physical	26186194
CGBP1_HUMAN	CGGBP1	physical	26186194
PARP2_HUMAN	PARP2	physical	26186194
WDR76_HUMAN	WDR76	physical	26186194
MCM2_HUMAN	MCM2	physical	26186194
XPP1_HUMAN	XPNPEP1	physical	26186194
H2B1J_HUMAN	HIST1H2BJ	physical	26186194
MCM6_HUMAN	MCM6	physical	26186194
SSRP1_HUMAN	SSRP1	physical	26186194
H2A2B_HUMAN	HIST2H2AB	physical	26186194
YRDC_HUMAN	YRDC	physical	26186194
MCM4_HUMAN	MCM4	physical	26186194
CK084_HUMAN	C11orf84	physical	26186194
UBR7_HUMAN	UBR7	physical	26186194
DAXX_HUMAN	DAXX	physical	26186194
RHG39_HUMAN	ARHGAP39	physical	26186194
F122B_HUMAN	FAM122B	physical	26186194
TOPRS_HUMAN	TOPORS	physical	26186194
SPIN1_HUMAN	SPIN1	physical	28514442
CK084_HUMAN	C11orf84	physical	28514442
CGBP1_HUMAN	CGGBP1	physical	28514442
RHG39_HUMAN	ARHGAP39	physical	28514442
XPP1_HUMAN	XPNPEP1	physical	28514442
UBR7_HUMAN	UBR7	physical	28514442
YRDC_HUMAN	YRDC	physical	28514442
F122B_HUMAN	FAM122B	physical	28514442
PARP2_HUMAN	PARP2	physical	28514442
SP16H_HUMAN	SUPT16H	physical	28514442
WDHD1_HUMAN	WDHD1	physical	28514442
DAXX_HUMAN	DAXX	physical	28514442
TOPRS_HUMAN	TOPORS	physical	28514442
XPC_HUMAN	XPC	physical	28514442
MCM2_HUMAN	MCM2	physical	28514442
SSRP1_HUMAN	SSRP1	physical	28514442
MCM6_HUMAN	MCM6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.