CGBP1_HUMAN - dbPTM
CGBP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CGBP1_HUMAN
UniProt AC Q9UFW8
Protein Name CGG triplet repeat-binding protein 1
Gene Name CGGBP1
Organism Homo sapiens (Human).
Sequence Length 167
Subcellular Localization Nucleus .
Protein Description Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter..
Protein Sequence MERFVVTAPPARNRSKTALYVTPLDRVTEFGGELHEDGGKLFCTSCNVVLNHVRKSAISDHLKSKTHTKRKAEFEEQNVRKKQRPLTASLQCNSTAQTEKVSVIQDFVKMCLEANIPLEKADHPAVRAFLSRHVKNGGSIPKSDQLRRAYLPDGYENENQLLNSQDC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationAPPARNRSKTALYVT
CCCCCCCCCCEEEEE
37.6023401153
16UbiquitinationPPARNRSKTALYVTP
CCCCCCCCCEEEEEC
34.2824816145
17PhosphorylationPARNRSKTALYVTPL
CCCCCCCCEEEEECH
24.1226074081
20PhosphorylationNRSKTALYVTPLDRV
CCCCCEEEEECHHHH
10.3828796482
22PhosphorylationSKTALYVTPLDRVTE
CCCEEEEECHHHHHC
12.4629978859
26MethylationLYVTPLDRVTEFGGE
EEEECHHHHHCCCCE
44.96-
40UbiquitinationELHEDGGKLFCTSCN
EEECCCCEEEEEECH
43.8729967540
56PhosphorylationVLNHVRKSAISDHLK
HHHHHHHHHHHHHHH
21.9225159151
59PhosphorylationHVRKSAISDHLKSKT
HHHHHHHHHHHHCCC
20.7726270265
71AcetylationSKTHTKRKAEFEEQN
CCCCCHHHHHHHHHH
54.5520167786
82UbiquitinationEEQNVRKKQRPLTAS
HHHHHHHHCCCCCEE
40.7629967540
89PhosphorylationKQRPLTASLQCNSTA
HCCCCCEEEECCCCC
17.4628555341
111GlutathionylationIQDFVKMCLEANIPL
HHHHHHHHHHCCCCH
2.2922555962
120UbiquitinationEANIPLEKADHPAVR
HCCCCHHHCCCHHHH
67.7929967540
131PhosphorylationPAVRAFLSRHVKNGG
HHHHHHHHHHHHCCC
17.5624719451
139PhosphorylationRHVKNGGSIPKSDQL
HHHHCCCCCCCHHHH
36.8024719451
143PhosphorylationNGGSIPKSDQLRRAY
CCCCCCCHHHHHHHH
25.8224719451
150PhosphorylationSDQLRRAYLPDGYEN
HHHHHHHHCCCCCCC
19.5620068231
155PhosphorylationRAYLPDGYENENQLL
HHHCCCCCCCHHHHC
23.9820068231
164PhosphorylationNENQLLNSQDC----
CHHHHCCCCCC----
27.6217525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
164SPhosphorylationKinaseATRQ13535
GPS

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CGBP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CGBP1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CGBP1_HUMANCGGBP1physical
25416956
GLRX3_HUMANGLRX3physical
25416956
F124A_HUMANFAM124Aphysical
25416956
DDB1_HUMANDDB1physical
26344197

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CGBP1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, AND MASSSPECTROMETRY.

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