CGBP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CGBP1_HUMAN
• UniProt AC: Q9UFW8
• Protein Name: CGG triplet repeat-binding protein 1
• Gene Name: CGGBP1
• Organism: Homo sapiens (Human).
• Sequence Length: 167
• Subcellular Localization: Nucleus .
• Protein Description: Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter..
• Protein Sequence: MERFVVTAPPARNRSKTALYVTPLDRVTEFGGELHEDGGKLFCTSCNVVLNHVRKSAISDHLKSKTHTKRKAEFEEQNVRKKQRPLTASLQCNSTAQTEKVSVIQDFVKMCLEANIPLEKADHPAVRAFLSRHVKNGGSIPKSDQLRRAYLPDGYENENQLLNSQDC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	APPARNRSKTALYVT CCCCCCCCCCEEEEE	37.60	23401153
16	Ubiquitination	PPARNRSKTALYVTP CCCCCCCCCEEEEEC	34.28	24816145
17	Phosphorylation	PARNRSKTALYVTPL CCCCCCCCEEEEECH	24.12	26074081
20	Phosphorylation	NRSKTALYVTPLDRV CCCCCEEEEECHHHH	10.38	28796482
22	Phosphorylation	SKTALYVTPLDRVTE CCCEEEEECHHHHHC	12.46	29978859
26	Methylation	LYVTPLDRVTEFGGE EEEECHHHHHCCCCE	44.96	-
40	Ubiquitination	ELHEDGGKLFCTSCN EEECCCCEEEEEECH	43.87	29967540
56	Phosphorylation	VLNHVRKSAISDHLK HHHHHHHHHHHHHHH	21.92	25159151
59	Phosphorylation	HVRKSAISDHLKSKT HHHHHHHHHHHHCCC	20.77	26270265
71	Acetylation	SKTHTKRKAEFEEQN CCCCCHHHHHHHHHH	54.55	20167786
82	Ubiquitination	EEQNVRKKQRPLTAS HHHHHHHHCCCCCEE	40.76	29967540
89	Phosphorylation	KQRPLTASLQCNSTA HCCCCCEEEECCCCC	17.46	28555341
111	Glutathionylation	IQDFVKMCLEANIPL HHHHHHHHHHCCCCH	2.29	22555962
120	Ubiquitination	EANIPLEKADHPAVR HCCCCHHHCCCHHHH	67.79	29967540
131	Phosphorylation	PAVRAFLSRHVKNGG HHHHHHHHHHHHCCC	17.56	24719451
139	Phosphorylation	RHVKNGGSIPKSDQL HHHHCCCCCCCHHHH	36.80	24719451
143	Phosphorylation	NGGSIPKSDQLRRAY CCCCCCCHHHHHHHH	25.82	24719451
150	Phosphorylation	SDQLRRAYLPDGYEN HHHHHHHHCCCCCCC	19.56	20068231
155	Phosphorylation	RAYLPDGYENENQLL HHHCCCCCCCHHHHC	23.98	20068231
164	Phosphorylation	NENQLLNSQDC---- CHHHHCCCCCC----	27.62	17525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
164	S	Phosphorylation	Kinase	ATR	Q13535	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CGBP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CGBP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CGBP1_HUMAN	CGGBP1	physical	25416956
GLRX3_HUMAN	GLRX3	physical	25416956
F124A_HUMAN	FAM124A	physical	25416956
DDB1_HUMAN	DDB1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, AND MASSSPECTROMETRY.
PubMed: 17525332