WDR76_HUMAN - dbPTM
WDR76_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDR76_HUMAN
UniProt AC Q9H967
Protein Name WD repeat-containing protein 76
Gene Name WDR76
Organism Homo sapiens (Human).
Sequence Length 626
Subcellular Localization
Protein Description Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC..
Protein Sequence MSRSGAAAEKADSRQRPQMKVNEYKENQNIAYVSLRPAQTTVLIKTAKVYLAPFSLSNYQLDQLMCPKSLSEKNSNNEVACKKTKIKKTCRRIIPPKMKNTSSKAESTLQNSSSAVHTESNKLQPKRTADAMNLSVDVESSQDGDSDEDTTPSLDFSGLSPYERKRLKNISENADFFASLQLSESAARLREMIEKRQPPKSKRKKPKRENGIGCRRSMRLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGMSKPSSKNTEKGLSSIKSYKANLNGMVISEDTVYKVTTGPIFSMALHPSETRTLVAVGAKFGQVGLCDLTQQPKEDGVYVFHPHSQPVSCLYFSPANPAHILSLSYDGTLRCGDFSRAIFEEVYRNERSSFSSFDFLAEDASTLIVGHWDGNMSLVDRRTPGTSYEKLTSSSMGKIRTVHVHPVHRQYFITAGLRDTHIYDARRLNSRRSQPLISLTEHTKSIASAYFSPLTGNRVVTTCADCNLRIFDSSCISSKIPLLTTIRHNTFTGRWLTRFQAMWDPKQEDCVIVGSMAHPRRVEIFHETGKRVHSFGGEYLVSVCSINAMHPTRYILAGGNSSGKIHVFMNEKSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSRSGAAAE
------CCCCCHHHH		34.8429083192
4Phosphorylation----MSRSGAAAEKA
----CCCCCHHHHHH		26.0229083192
10UbiquitinationRSGAAAEKADSRQRP
CCCHHHHHHHHCCCC		53.41-
13PhosphorylationAAAEKADSRQRPQMK
HHHHHHHHCCCCCCH		34.8629083192
20UbiquitinationSRQRPQMKVNEYKEN
HCCCCCCHHHHHHCC		36.34-
25UbiquitinationQMKVNEYKENQNIAY
CCHHHHHHCCCCEEE		43.97-
32PhosphorylationKENQNIAYVSLRPAQ
HCCCCEEEEEECCCC		6.1827642862
34PhosphorylationNQNIAYVSLRPAQTT
CCCEEEEEECCCCEE		13.1429507054
40PhosphorylationVSLRPAQTTVLIKTA
EEECCCCEEEEEEEC		22.4520860994
41PhosphorylationSLRPAQTTVLIKTAK
EECCCCEEEEEEECE		10.9620860994
68UbiquitinationLDQLMCPKSLSEKNS
CCCCCCCHHHCCCCC		60.13-
69PhosphorylationDQLMCPKSLSEKNSN
CCCCCCHHHCCCCCC		23.4426699800
71PhosphorylationLMCPKSLSEKNSNNE
CCCCHHHCCCCCCCC		54.3226699800
73UbiquitinationCPKSLSEKNSNNEVA
CCHHHCCCCCCCCCC		63.40-
101PhosphorylationIPPKMKNTSSKAEST
CCCCCCCCCHHHHHH		28.9420860994
102PhosphorylationPPKMKNTSSKAESTL
CCCCCCCCHHHHHHH		38.95-
104AcetylationKMKNTSSKAESTLQN
CCCCCCHHHHHHHHC		56.8126051181
104SumoylationKMKNTSSKAESTLQN
CCCCCCHHHHHHHHC		56.81-
104SumoylationKMKNTSSKAESTLQN
CCCCCCHHHHHHHHC		56.81-
104UbiquitinationKMKNTSSKAESTLQN
CCCCCCHHHHHHHHC		56.8121906983
112PhosphorylationAESTLQNSSSAVHTE
HHHHHHCCCCCCCCC		16.8325627689
113PhosphorylationESTLQNSSSAVHTES
HHHHHCCCCCCCCCC		29.8425627689
122AcetylationAVHTESNKLQPKRTA
CCCCCCCCCCCCCCH		58.7525953088
122UbiquitinationAVHTESNKLQPKRTA
CCCCCCCCCCCCCCH		58.75-
171PhosphorylationRKRLKNISENADFFA
HHHHCCHHHCCCHHH		33.90-
179PhosphorylationENADFFASLQLSESA
HCCCHHHHHHHHHHH		16.11-
217PhosphorylationNGIGCRRSMRLLKVD
CCCCCHHHEEEEEEC		6.7326074081
235PhosphorylationVSLPAAPTPPTLVAD
CCCCCCCCCCCEEEC		36.8528348404
238PhosphorylationPAAPTPPTLVADETP
CCCCCCCCEEECCCC		34.7628348404
244PhosphorylationPTLVADETPLLPPGP
CCEEECCCCCCCCCC		21.5628348404
267UbiquitinationEDNNERFKGFLHTWA
CCCCHHHHHHHHHHH		55.78-
272PhosphorylationRFKGFLHTWAGMSKP
HHHHHHHHHHCCCCC		21.1129083192
277PhosphorylationLHTWAGMSKPSSKNT
HHHHHCCCCCCCCCC		40.2629083192
278UbiquitinationHTWAGMSKPSSKNTE
HHHHCCCCCCCCCCH		39.77-
280PhosphorylationWAGMSKPSSKNTEKG
HHCCCCCCCCCCHHH		58.6529083192
281PhosphorylationAGMSKPSSKNTEKGL
HCCCCCCCCCCHHHH		38.1529083192
284PhosphorylationSKPSSKNTEKGLSSI
CCCCCCCCHHHHHHH		42.6929083192
286UbiquitinationPSSKNTEKGLSSIKS
CCCCCCHHHHHHHHH		64.21-
289PhosphorylationKNTEKGLSSIKSYKA
CCCHHHHHHHHHHHC		38.3924719451
292AcetylationEKGLSSIKSYKANLN
HHHHHHHHHHHCCCC		50.0825953088
292UbiquitinationEKGLSSIKSYKANLN
HHHHHHHHHHHCCCC		50.08-
294PhosphorylationGLSSIKSYKANLNGM
HHHHHHHHHCCCCCC		14.76-
295UbiquitinationLSSIKSYKANLNGMV
HHHHHHHHCCCCCCE		37.58-
335UbiquitinationTLVAVGAKFGQVGLC
EEEEECCCCCCEECC		44.06-
442UbiquitinationTPGTSYEKLTSSSMG
CCCCCHHHHHHCCCC		49.1621906983
444PhosphorylationGTSYEKLTSSSMGKI
CCCHHHHHHCCCCCE		37.3229083192
445PhosphorylationTSYEKLTSSSMGKIR
CCHHHHHHCCCCCEE		30.7429083192
446PhosphorylationSYEKLTSSSMGKIRT
CHHHHHHCCCCCEEE		21.0729083192
447PhosphorylationYEKLTSSSMGKIRTV
HHHHHHCCCCCEEEE		31.1829083192
450UbiquitinationLTSSSMGKIRTVHVH
HHHCCCCCEEEEEEE		22.00-
485PhosphorylationRRLNSRRSQPLISLT
HHHHCCCCCCCEEHH		34.73-
490PhosphorylationRRSQPLISLTEHTKS
CCCCCCEEHHHCHHH		36.60-
492PhosphorylationSQPLISLTEHTKSIA
CCCCEEHHHCHHHHH		20.94-
495PhosphorylationLISLTEHTKSIASAY
CEEHHHCHHHHHHHH		21.91-
496UbiquitinationISLTEHTKSIASAYF
EEHHHCHHHHHHHHC		41.60-
531UbiquitinationDSSCISSKIPLLTTI
CCHHHHCCCCEEEEE		41.37-
558UbiquitinationFQAMWDPKQEDCVIV
HHHHCCCCCCCCEEE		64.94-
582UbiquitinationEIFHETGKRVHSFGG
EEEEECCCEEEEECC		59.68-
624UbiquitinationIHVFMNEKSC-----
EEEEECCCCC-----		52.71-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDR76_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDR76_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDR76_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HELLS_HUMANHELLSphysical
25817432
SRRM2_HUMANSRRM2physical
25817432
TCPB_HUMANCCT2physical
25817432
XRCC6_HUMANXRCC6physical
25817432
XRCC5_HUMANXRCC5physical
25817432
ZCCHV_HUMANZC3HAV1physical
25817432
RACK1_HUMANGNB2L1physical
25817432
SGT1_HUMANSUGT1physical
25817432
RSSA_HUMANRPSAphysical
25817432
HS90A_HUMANHSP90AA1physical
25817432
PARP1_HUMANPARP1physical
25817432
BAG2_HUMANBAG2physical
25817432
TCPH_HUMANCCT7physical
25817432
TCPQ_HUMANCCT8physical
25817432
TCPE_HUMANCCT5physical
25817432
TCPG_HUMANCCT3physical
25817432
PPIB_HUMANPPIBphysical
25817432
LRC59_HUMANLRRC59physical
25817432
TCPD_HUMANCCT4physical
25817432
CPSF5_HUMANNUDT21physical
25817432
FXR1_HUMANFXR1physical
25817432
C1QBP_HUMANC1QBPphysical
25817432
HMGB1_HUMANHMGB1physical
25817432
RS23_HUMANRPS23physical
25817432
RL22_HUMANRPL22physical
25817432
SSRP1_HUMANSSRP1physical
25817432
RS18_HUMANRPS18physical
25817432
RS25_HUMANRPS25physical
25817432
FEN1_HUMANFEN1physical
25817432
RS17_HUMANRPS17physical
25817432
GAN_HUMANGANphysical
28514442
PARP2_HUMANPARP2physical
28514442
SP16H_HUMANSUPT16Hphysical
28514442
XPC_HUMANXPCphysical
28514442
DNLI3_HUMANLIG3physical
28514442
SSRP1_HUMANSSRP1physical
28514442
HELLS_HUMANHELLSphysical
28514442
PARP1_HUMANPARP1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDR76_HUMAN

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Related Literatures of Post-Translational Modification

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