| UniProt ID | RACK1_HUMAN | |
|---|---|---|
| UniProt AC | P63244 | |
| Protein Name | Receptor of activated protein C kinase 1 | |
| Gene Name | RACK1 {ECO:0000312|HGNC:HGNC:4399} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 317 | |
| Subcellular Localization |
Cell membrane Peripheral membrane protein. Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Perikaryon . Cell projection, dendrite . Cell projection, phagocytic cup . Recruited to the plasma membrane through interaction with KRT1 which binds t |
|
| Protein Description | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. [PubMed: 23636399 Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits] | |
| Protein Sequence | MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MTEQMTLR -------CCCEEEEC | 22814378 | ||
| 2 | Acetylation | ------MTEQMTLRG ------CCCEEEECE | 21406692 | ||
| 2 | Phosphorylation | ------MTEQMTLRG ------CCCEEEECE | 20363803 | ||
| 6 | Phosphorylation | --MTEQMTLRGTLKG --CCCEEEECEEEEC | 25159151 | ||
| 8 | Methylation | MTEQMTLRGTLKGHN CCCEEEECEEEECCC | 115490059 | ||
| 10 | Phosphorylation | EQMTLRGTLKGHNGW CEEEECEEEECCCCC | 21406692 | ||
| 12 | Acetylation | MTLRGTLKGHNGWVT EEECEEEECCCCCEE | 26051181 | ||
| 12 | Methylation | MTLRGTLKGHNGWVT EEECEEEECCCCCEE | 24633395 | ||
| 12 | Ubiquitination | MTLRGTLKGHNGWVT EEECEEEECCCCCEE | 21906983 | ||
| 19 | Phosphorylation | KGHNGWVTQIATTPQ ECCCCCEEEEEECCC | 21406692 | ||
| 23 | Phosphorylation | GWVTQIATTPQFPDM CCEEEEEECCCCCHH | 21406692 | ||
| 24 | Phosphorylation | WVTQIATTPQFPDMI CEEEEEECCCCCHHH | 21406692 | ||
| 30 | Sulfoxidation | TTPQFPDMILSASRD ECCCCCHHHEECCCC | 28465586 | ||
| 33 | Phosphorylation | QFPDMILSASRDKTI CCCHHHEECCCCCEE | 21406692 | ||
| 35 | Phosphorylation | PDMILSASRDKTIIM CHHHEECCCCCEEEE | 21406692 | ||
| 38 | 2-Hydroxyisobutyrylation | ILSASRDKTIIMWKL HEECCCCCEEEEEEE | - | ||
| 38 | Acetylation | ILSASRDKTIIMWKL HEECCCCCEEEEEEE | 25953088 | ||
| 38 | Ubiquitination | ILSASRDKTIIMWKL HEECCCCCEEEEEEE | 21906983 | ||
| 39 | O-linked_Glycosylation | LSASRDKTIIMWKLT EECCCCCEEEEEEEC | 23301498 | ||
| 39 | Phosphorylation | LSASRDKTIIMWKLT EECCCCCEEEEEEEC | 20068231 | ||
| 44 | Acetylation | DKTIIMWKLTRDETN CCEEEEEEECCCCCC | 26051181 | ||
| 44 | Ubiquitination | DKTIIMWKLTRDETN CCEEEEEEECCCCCC | 21906983 | ||
| 46 | Phosphorylation | TIIMWKLTRDETNYG EEEEEEECCCCCCCC | 28152594 | ||
| 47 | Methylation | IIMWKLTRDETNYGI EEEEEECCCCCCCCC | 115490051 | ||
| 50 | Phosphorylation | WKLTRDETNYGIPQR EEECCCCCCCCCCHH | 28796482 | ||
| 52 | Nitration | LTRDETNYGIPQRAL ECCCCCCCCCCHHHH | - | ||
| 52 | Phosphorylation | LTRDETNYGIPQRAL ECCCCCCCCCCHHHH | 28796482 | ||
| 63 | Phosphorylation | QRALRGHSHFVSDVV HHHHCCCCCEEEEEE | - | ||
| 93 | Phosphorylation | TLRLWDLTTGTTTRR EEEEEECCCCCCEEE | 23312004 | ||
| 94 | Phosphorylation | LRLWDLTTGTTTRRF EEEEECCCCCCEEEE | 23312004 | ||
| 96 | Phosphorylation | LWDLTTGTTTRRFVG EEECCCCCCEEEECC | 23403867 | ||
| 97 | Phosphorylation | WDLTTGTTTRRFVGH EECCCCCCEEEECCC | 23403867 | ||
| 98 | Phosphorylation | DLTTGTTTRRFVGHT ECCCCCCEEEECCCC | 24275569 | ||
| 105 | Phosphorylation | TRRFVGHTKDVLSVA EEEECCCCCCEEEEE | 24275569 | ||
| 106 | 2-Hydroxyisobutyrylation | RRFVGHTKDVLSVAF EEECCCCCCEEEEEE | - | ||
| 106 | Acetylation | RRFVGHTKDVLSVAF EEECCCCCCEEEEEE | 26051181 | ||
| 106 | Ubiquitination | RRFVGHTKDVLSVAF EEECCCCCCEEEEEE | 21906983 | ||
| 110 | Phosphorylation | GHTKDVLSVAFSSDN CCCCCEEEEEECCCC | 21406692 | ||
| 114 | Phosphorylation | DVLSVAFSSDNRQIV CEEEEEECCCCCEEE | 21406692 | ||
| 115 | Phosphorylation | VLSVAFSSDNRQIVS EEEEEECCCCCEEEC | 21406692 | ||
| 122 | Phosphorylation | SDNRQIVSGSRDKTI CCCCEEECCCCCHHE | 21406692 | ||
| 124 | O-linked_Glycosylation | NRQIVSGSRDKTIKL CCEEECCCCCHHEEH | 23301498 | ||
| 124 | Phosphorylation | NRQIVSGSRDKTIKL CCEEECCCCCHHEEH | 21406692 | ||
| 128 | Phosphorylation | VSGSRDKTIKLWNTL ECCCCCHHEEHHHHC | - | ||
| 130 | Sumoylation | GSRDKTIKLWNTLGV CCCCHHEEHHHHCCC | - | ||
| 130 | Acetylation | GSRDKTIKLWNTLGV CCCCHHEEHHHHCCC | 19608861 | ||
| 130 | Malonylation | GSRDKTIKLWNTLGV CCCCHHEEHHHHCCC | 26320211 | ||
| 130 | Sumoylation | GSRDKTIKLWNTLGV CCCCHHEEHHHHCCC | 19608861 | ||
| 130 | Ubiquitination | GSRDKTIKLWNTLGV CCCCHHEEHHHHCCC | 20639865 | ||
| 134 | Phosphorylation | KTIKLWNTLGVCKYT HHEEHHHHCCCCEEE | 23312004 | ||
| 138 | S-nitrosocysteine | LWNTLGVCKYTVQDE HHHHCCCCEEEECCC | - | ||
| 138 | S-palmitoylation | LWNTLGVCKYTVQDE HHHHCCCCEEEECCC | 29575903 | ||
| 139 | Acetylation | WNTLGVCKYTVQDES HHHCCCCEEEECCCC | 25953088 | ||
| 139 | Ubiquitination | WNTLGVCKYTVQDES HHHCCCCEEEECCCC | 21906983 | ||
| 140 | Phosphorylation | NTLGVCKYTVQDESH HHCCCCEEEECCCCC | 28152594 | ||
| 141 | Phosphorylation | TLGVCKYTVQDESHS HCCCCEEEECCCCCC | 28152594 | ||
| 146 | Phosphorylation | KYTVQDESHSEWVSC EEEECCCCCCCCEEE | 28152594 | ||
| 157 | Phosphorylation | WVSCVRFSPNSSNPI CEEEEEECCCCCCCE | 20873877 | ||
| 160 | Phosphorylation | CVRFSPNSSNPIIVS EEEECCCCCCCEEEE | 25850435 | ||
| 161 | Phosphorylation | VRFSPNSSNPIIVSC EEECCCCCCCEEEEE | 25850435 | ||
| 167 | Phosphorylation | SSNPIIVSCGWDKLV CCCCEEEEECHHHHH | 21712546 | ||
| 168 | S-nitrosocysteine | SNPIIVSCGWDKLVK CCCEEEEECHHHHHH | - | ||
| 172 | 2-Hydroxyisobutyrylation | IVSCGWDKLVKVWNL EEEECHHHHHHHHHH | - | ||
| 172 | Acetylation | IVSCGWDKLVKVWNL EEEECHHHHHHHHHH | 25953088 | ||
| 172 | Methylation | IVSCGWDKLVKVWNL EEEECHHHHHHHHHH | 70595 | ||
| 172 | Ubiquitination | IVSCGWDKLVKVWNL EEEECHHHHHHHHHH | 21906983 | ||
| 175 | Acetylation | CGWDKLVKVWNLANC ECHHHHHHHHHHCCC | 26051181 | ||
| 175 | Ubiquitination | CGWDKLVKVWNLANC ECHHHHHHHHHHCCC | 21906983 | ||
| 182 | S-nitrosocysteine | KVWNLANCKLKTNHI HHHHHCCCEEECCCC | - | ||
| 183 | Acetylation | VWNLANCKLKTNHIG HHHHCCCEEECCCCC | 23954790 | ||
| 183 | Malonylation | VWNLANCKLKTNHIG HHHHCCCEEECCCCC | 26320211 | ||
| 183 | Ubiquitination | VWNLANCKLKTNHIG HHHHCCCEEECCCCC | 21890473 | ||
| 185 | 2-Hydroxyisobutyrylation | NLANCKLKTNHIGHT HHCCCEEECCCCCCC | - | ||
| 185 | Acetylation | NLANCKLKTNHIGHT HHCCCEEECCCCCCC | 26051181 | ||
| 185 | Ubiquitination | NLANCKLKTNHIGHT HHCCCEEECCCCCCC | 20639865 | ||
| 186 | Phosphorylation | LANCKLKTNHIGHTG HCCCEEECCCCCCCC | 28442448 | ||
| 192 | Phosphorylation | KTNHIGHTGYLNTVT ECCCCCCCCEEEEEE | 28442448 | ||
| 194 | Phosphorylation | NHIGHTGYLNTVTVS CCCCCCCEEEEEEEC | 15240704 | ||
| 197 | Phosphorylation | GHTGYLNTVTVSPDG CCCCEEEEEEECCCC | 28442448 | ||
| 199 | Phosphorylation | TGYLNTVTVSPDGSL CCEEEEEEECCCCCC | 28442448 | ||
| 201 | Phosphorylation | YLNTVTVSPDGSLCA EEEEEEECCCCCCCC | 28442448 | ||
| 205 | Phosphorylation | VTVSPDGSLCASGGK EEECCCCCCCCCCCC | 25693802 | ||
| 209 | Phosphorylation | PDGSLCASGGKDGQA CCCCCCCCCCCCCCE | 25693802 | ||
| 212 | 2-Hydroxyisobutyrylation | SLCASGGKDGQAMLW CCCCCCCCCCCEEEE | - | ||
| 212 | Acetylation | SLCASGGKDGQAMLW CCCCCCCCCCCEEEE | 26051181 | ||
| 212 | Ubiquitination | SLCASGGKDGQAMLW CCCCCCCCCCCEEEE | - | ||
| 217 | Sulfoxidation | GGKDGQAMLWDLNEG CCCCCCEEEEECCCC | 30846556 | ||
| 225 | Acetylation | LWDLNEGKHLYTLDG EEECCCCCEEEEECC | 26051181 | ||
| 225 | Ubiquitination | LWDLNEGKHLYTLDG EEECCCCCEEEEECC | - | ||
| 228 | Phosphorylation | LNEGKHLYTLDGGDI CCCCCEEEEECCCCC | 12400005 | ||
| 229 | Phosphorylation | NEGKHLYTLDGGDII CCCCEEEEECCCCCE | 28152594 | ||
| 240 | S-palmitoylation | GDIINALCFSPNRYW CCCEEEEEECCCCEE | 29575903 | ||
| 242 | Phosphorylation | IINALCFSPNRYWLC CEEEEEECCCCEEEE | 20873877 | ||
| 245 | Methylation | ALCFSPNRYWLCAAT EEEECCCCEEEEEEC | 115490043 | ||
| 246 | Phosphorylation | LCFSPNRYWLCAATG EEECCCCEEEEEECC | 12400005 | ||
| 249 | S-nitrosocysteine | SPNRYWLCAATGPSI CCCCEEEEEECCCEE | - | ||
| 255 | Phosphorylation | LCAATGPSIKIWDLE EEEECCCEEEEEECC | 21712546 | ||
| 257 | Acetylation | AATGPSIKIWDLEGK EECCCEEEEEECCCC | 26051181 | ||
| 257 | Ubiquitination | AATGPSIKIWDLEGK EECCCEEEEEECCCC | 21906983 | ||
| 264 | 2-Hydroxyisobutyrylation | KIWDLEGKIIVDELK EEEECCCCEEHHHHH | - | ||
| 264 | Ubiquitination | KIWDLEGKIIVDELK EEEECCCCEEHHHHH | 21906983 | ||
| 271 | Sumoylation | KIIVDELKQEVISTS CEEHHHHHHHHHCCC | - | ||
| 271 | 2-Hydroxyisobutyrylation | KIIVDELKQEVISTS CEEHHHHHHHHHCCC | - | ||
| 271 | Acetylation | KIIVDELKQEVISTS CEEHHHHHHHHHCCC | 26822725 | ||
| 271 | Methylation | KIIVDELKQEVISTS CEEHHHHHHHHHCCC | 66701141 | ||
| 271 | Succinylation | KIIVDELKQEVISTS CEEHHHHHHHHHCCC | 23954790 | ||
| 271 | Sumoylation | KIIVDELKQEVISTS CEEHHHHHHHHHCCC | - | ||
| 271 | Ubiquitination | KIIVDELKQEVISTS CEEHHHHHHHHHCCC | 21890473 | ||
| 276 | Phosphorylation | ELKQEVISTSSKAEP HHHHHHHCCCCCCCC | 25159151 | ||
| 277 | O-linked_Glycosylation | LKQEVISTSSKAEPP HHHHHHCCCCCCCCC | 23301498 | ||
| 277 | Phosphorylation | LKQEVISTSSKAEPP HHHHHHCCCCCCCCC | 25849741 | ||
| 278 | Phosphorylation | KQEVISTSSKAEPPQ HHHHHCCCCCCCCCC | 29632367 | ||
| 279 | O-linked_Glycosylation | QEVISTSSKAEPPQC HHHHCCCCCCCCCCC | 23301498 | ||
| 279 | Phosphorylation | QEVISTSSKAEPPQC HHHHCCCCCCCCCCC | 29632367 | ||
| 280 | Methylation | EVISTSSKAEPPQCT HHHCCCCCCCCCCCC | - | ||
| 280 | Ubiquitination | EVISTSSKAEPPQCT HHHCCCCCCCCCCCC | - | ||
| 302 | Phosphorylation | GQTLFAGYTDNLVRV CCEEEEEECCCEEEE | 18567578 | ||
| 313 | Phosphorylation | LVRVWQVTIGTR--- EEEEEEEEECCC--- | 28102081 | ||
| 316 | Phosphorylation | VWQVTIGTR------ EEEEEECCC------ | 25159151 | ||
| 317 | Methylation | WQVTIGTR------- EEEEECCC------- | 115490067 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 50 | T | Phosphorylation | Kinase | PRKAA1 | Q13131 | GPS |
| 52 | Y | Phosphorylation | Kinase | ABL | P00519 | PSP |
| 52 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 52 | Y | Phosphorylation | Kinase | ABL-FAMILY | - | GPS |
| 194 | Y | Phosphorylation | Kinase | TYK2 | P29597 | PSP |
| 228 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 228 | Y | Phosphorylation | Kinase | SRC64 | - | PhosphoELM |
| 246 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 246 | Y | Phosphorylation | Kinase | SRC64 | - | PhosphoELM |
| 276 | S | Phosphorylation | Kinase | VIRAL VACV B1 KINASE | - | Uniprot |
| 277 | T | Phosphorylation | Kinase | VIRAL VACV B1 KINASE | - | Uniprot |
| 278 | S | Phosphorylation | Kinase | VIRAL VACV B1 KINASE | - | Uniprot |
| 279 | S | Phosphorylation | Kinase | VIRAL VACV B1 KINASE | - | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RACK1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RACK1_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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