IL4RA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL4RA_HUMAN
• UniProt AC: P24394
• Protein Name: Interleukin-4 receptor subunit alpha
• Gene Name: IL4R
• Organism: Homo sapiens (Human).
• Sequence Length: 825
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
• Protein Description: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.; Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells..
• Protein Sequence: MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQHLLLGVSVSCIVILAVCLLCYVSITKIKKEWWDQIPNPARSRLVAIIIQDAQGSQWEKRSRGQEPAKCPHWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQGSGKSAWCPVEISKTVLWPESISVVRCVELFEAPVECEEEEEVEEEKGSFCASPESSRDDFQEGREGIVARLTESLFLDLLGEENGGFCQQDMGESCLLPPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQSPDNLTCTETPLVIAGNPAYRSFSNSLSQSPCPRELGPDPLLARHLEEVEPEMPCVPQLSEPTTVPQPEPETWEQILRRNVLQHGAAAAPVSAPTSGYQEFVHAVEQGGTQASAVVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTFGLDREPPRSPQSSHLPSSSPEHLGLEPGEKVEDMPKPPLPQEQATDPLVDSLGSGIVYSALTCHLCGHLKQCHGQEDGGQTPVMASPCCGCCCGDRSSPPTTPLRAPDPSPGGVPLEASLCPASLAPSGISEKSKSSSSFHPAPGNAQSSSQTPKIVNFVSVGPTYMRVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	SGLLFPVSCLVLLQV HHCHHHHHHHHHHHH	11.28	24719451
22	Phosphorylation	LVLLQVASSGNMKVL HHHHHHHHCCCCEEE	39.66	24719451
53	N-linked_Glycosylation	WKMNGPTNCSTELRL EECCCCCCCHHHHHH	22.37	UniProtKB CARBOHYD
98	N-linked_Glycosylation	DDVVSADNYTLDLWA CCCCCCCCEEEEEEC	31.26	UniProtKB CARBOHYD
114	Phosphorylation	QQLLWKGSFKPSEHV CEEEECCCCCCHHCC	26.77	27282143
128	N-linked_Glycosylation	VKPRAPGNLTVHTNV CCCCCCCCEEEEECC	31.32	UniProtKB CARBOHYD
134	N-linked_Glycosylation	GNLTVHTNVSDTLLL CCEEEEECCCCCEEE	19.20	UniProtKB CARBOHYD
176	N-linked_Glycosylation	PADFRIYNVTYLEPS CCCCEEEEEEEECHH	19.79	UniProtKB CARBOHYD
177	Ubiquitination	ADFRIYNVTYLEPSL CCCEEEEEEEECHHH	1.77	-
192 (in isoform 2)	Ubiquitination	-	46.88	21906983
192 (in isoform 1)	Ubiquitination	-	46.88	21906983
192	Ubiquitination	RIAASTLKSGISYRA HHHHHHHHCCCCHHH	46.88	2190698
193	Phosphorylation	IAASTLKSGISYRAR HHHHHHHCCCCHHHH	44.46	23403867
196	Phosphorylation	STLKSGISYRARVRA HHHHCCCCHHHHHHH	16.46	23403867
209	N-linked_Glycosylation	RAWAQCYNTTWSEWS HHHHHHHCCCHHHCC	38.36	UniProtKB CARBOHYD
211	Phosphorylation	WAQCYNTTWSEWSPS HHHHHCCCHHHCCCC	24.29	30576142
219	Phosphorylation	WSEWSPSTKWHNSYR HHHCCCCCCCCCCCC	41.35	30576142
336	Phosphorylation	KEMPFQGSGKSAWCP HHCCCCCCCCCCCCC	32.06	28102081
355	Phosphorylation	KTVLWPESISVVRCV CEEECCCCEEEEEEE	18.98	29978859
357	Phosphorylation	VLWPESISVVRCVEL EECCCCEEEEEEEEE	24.68	29978859
383	Phosphorylation	EVEEEKGSFCASPES HHHHHCCCCCCCCCC	28.37	-
387	Phosphorylation	EKGSFCASPESSRDD HCCCCCCCCCCCCCC	30.31	27251275
390	Phosphorylation	SFCASPESSRDDFQE CCCCCCCCCCCCHHH	33.77	-
391	Phosphorylation	FCASPESSRDDFQEG CCCCCCCCCCCHHHC	37.76	-
470	Phosphorylation	QPLHLEPSPPASPTQ CCCCCCCCCCCCCCC	33.85	23401153
474	Phosphorylation	LEPSPPASPTQSPDN CCCCCCCCCCCCCCC	33.96	26657352
476	Phosphorylation	PSPPASPTQSPDNLT CCCCCCCCCCCCCCC	38.90	28450419
478	Phosphorylation	PPASPTQSPDNLTCT CCCCCCCCCCCCCCC	36.38	28450419
483	Phosphorylation	TQSPDNLTCTETPLV CCCCCCCCCCCCCEE	24.52	28450419
485	Phosphorylation	SPDNLTCTETPLVIA CCCCCCCCCCCEEEE	37.34	28450419
487	Phosphorylation	DNLTCTETPLVIAGN CCCCCCCCCEEEECC	12.08	28450419
497	Phosphorylation	VIAGNPAYRSFSNSL EEECCHHHHHCCCCC	14.19	8804422
505	Phosphorylation	RSFSNSLSQSPCPRE HHCCCCCCCCCCCHH	28.56	29978859
507	Phosphorylation	FSNSLSQSPCPRELG CCCCCCCCCCCHHHC	25.70	29978859
575	Phosphorylation	VSAPTSGYQEFVHAV CCCCCCCHHHHHHHH	12.49	8804422
603	Phosphorylation	GPPGEAGYKAFSSLL CCCCHHHHHHHHHHH	13.24	8804422
612	Phosphorylation	AFSSLLASSAVSPEK HHHHHHHHCCCCHHH	20.85	28102081
613	Phosphorylation	FSSLLASSAVSPEKC HHHHHHHCCCCHHHC	27.38	28102081
616	Phosphorylation	LLASSAVSPEKCGFG HHHHCCCCHHHCCCC	27.36	29396449
631	Phosphorylation	ASSGEEGYKPFQDLI CCCCCCCCCCHHHCC	20.83	11513543
664	Phosphorylation	LDREPPRSPQSSHLP CCCCCCCCCCCCCCC	32.82	27080861
667	Phosphorylation	EPPRSPQSSHLPSSS CCCCCCCCCCCCCCC	24.10	27080861
668	Phosphorylation	PPRSPQSSHLPSSSP CCCCCCCCCCCCCCH	24.64	27080861
672	Phosphorylation	PQSSHLPSSSPEHLG CCCCCCCCCCHHHCC	50.21	27080861
673	Phosphorylation	QSSHLPSSSPEHLGL CCCCCCCCCHHHCCC	48.23	27080861
674	Phosphorylation	SSHLPSSSPEHLGLE CCCCCCCCHHHCCCC	38.35	27080861
713	Phosphorylation	SLGSGIVYSALTCHL HCCCCHHHHHHHHHH	6.06	11714803
752	Phosphorylation	GCCCGDRSSPPTTPL CCCCCCCCCCCCCCC	52.52	23312004
753	Phosphorylation	CCCGDRSSPPTTPLR CCCCCCCCCCCCCCC	35.47	23312004
756	Phosphorylation	GDRSSPPTTPLRAPD CCCCCCCCCCCCCCC	44.42	23401153
791	Phosphorylation	GISEKSKSSSSFHPA CCCCCCCCCCCCCCC	42.41	-
816	Phosphorylation	PKIVNFVSVGPTYMR CCEEEEEEECCCEEE	19.74	28152594
820	Phosphorylation	NFVSVGPTYMRVS-- EEEEECCCEEECC--	24.83	28152594
821	Phosphorylation	FVSVGPTYMRVS--- EEEECCCEEECC---	6.00	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL4RA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL4RA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL4RA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHC1_HUMAN	SHC1	physical	10652211
PTN6_HUMAN	PTPN6	physical	11714803
SHIP1_HUMAN	INPP5D	physical	11714803
SHC1_HUMAN	SHC1	physical	11714803
PTN11_HUMAN	PTPN11	physical	11714803
JAK1_HUMAN	JAK1	physical	12133952
HGS_HUMAN	HGS	physical	21362618
KAT5_HUMAN	KAT5	physical	10486269
JAK1_HUMAN	JAK1	physical	12242343
SOCS5_HUMAN	SOCS5	physical	12242343
STAT6_HUMAN	STAT6	physical	9651359
JAK2_HUMAN	JAK2	physical	8609418
JAK3_HUMAN	JAK3	physical	12207328
TNR5_HUMAN	CD40	physical	12207328
RHDF2_HUMAN	RHBDF2	physical	28514442
ANKL2_HUMAN	ANKLE2	physical	28514442
JAK1_HUMAN	JAK1	physical	28514442
ARHG8_HUMAN	NET1	physical	28514442
PRR11_HUMAN	PRR11	physical	28514442
TYK2_HUMAN	TYK2	physical	28514442
UTP6_HUMAN	UTP6	physical	28514442
KCNT2_HUMAN	KCNT2	physical	28514442
PMYT1_HUMAN	PKMYT1	physical	28514442
STX5_HUMAN	STX5	physical	28514442
GOGA2_HUMAN	GOLGA2	physical	28514442
DHRS3_HUMAN	DHRS3	physical	28514442
RHBT3_HUMAN	RHOBTB3	physical	28514442
AVR2B_HUMAN	ACVR2B	physical	28514442
PKHH3_HUMAN	PLEKHH3	physical	28514442
ZDHC9_HUMAN	ZDHHC9	physical	28514442
DCAKD_HUMAN	DCAKD	physical	28514442
TR19L_HUMAN	RELT	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
ERBB2_HUMAN	ERBB2	physical	28514442
ARL5B_HUMAN	ARL5B	physical	28514442
PTN6_HUMAN	PTPN6	physical	27742835
GRB10_HUMAN	GRB10	physical	27742835
NED4L_HUMAN	NEDD4L	physical	27742835

Drug and Disease Associations

• Kegg Disease
• H00079: Asthma
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D10354: Dupilumab (USAN)
• DrugBank
• There are no disease associations of PTM sites.