DHRS3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHRS3_HUMAN
• UniProt AC: O75911
• Protein Name: Short-chain dehydrogenase/reductase 3
• Gene Name: DHRS3
• Organism: Homo sapiens (Human).
• Sequence Length: 302
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH..
• Protein Sequence: MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	MIYLVVKAAVGLVLP HHHHHHHHHHHHHHC	8.86	32015554
28	Ubiquitination	VKAAVGLVLPAKLRD HHHHHHHHHCHHHHH	5.04	33845483
32 (in isoform 2)	Ubiquitination	-	41.96	21890473
32	Ubiquitination	VGLVLPAKLRDLSRE HHHHHCHHHHHCCCC	41.96	27667366
32 (in isoform 1)	Ubiquitination	-	41.96	21890473
32	Ubiquitination	VGLVLPAKLRDLSRE HHHHHCHHHHHCCCC	41.96	21890473
45	Ubiquitination	RENVLITGGGRGIGR CCCEEEECCCCHHHH	29.57	22817900
48	Methylation	VLITGGGRGIGRQLA EEEECCCCHHHHHHH	36.51	-
57	Ubiquitination	IGRQLAREFAERGAR HHHHHHHHHHHHCCC	43.53	21963094
71	Ubiquitination	RKIVLWGRTEKCLKE CEEEEECCHHHHHHH	28.29	21963094
77	Ubiquitination	GRTEKCLKETTEEIR CCHHHHHHHHHHHHH	63.59	33845483
92	Phosphorylation	QMGTECHYFICDVGN HHCCCCCEEEEECCC	13.29	27642862
108	Ubiquitination	EEVYQTAKAVREKVG HHHHHHHHHHHHHCC	51.29	32015554
113	2-Hydroxyisobutyrylation	TAKAVREKVGDITIL HHHHHHHHCCCEEEE	40.74	-
113	Ubiquitination	TAKAVREKVGDITIL HHHHHHHHCCCEEEE	40.74	33845483
130	Ubiquitination	NAAVVHGKSLMDSDD CEEEECCCCCCCCCC	26.07	22817900
130 (in isoform 1)	Ubiquitination	-	26.07	21890473
135	Phosphorylation	HGKSLMDSDDDALLK CCCCCCCCCCHHHHH	29.04	-
142	Ubiquitination	SDDDALLKSQHINTL CCCHHHHHHHCHHCC	49.25	21906983
142 (in isoform 1)	Ubiquitination	-	49.25	21890473
156	Ubiquitination	LGQFWTTKAFLPRML CHHHHHHHHHHHHHH	29.75	21963094
156 (in isoform 1)	Ubiquitination	-	29.75	21890473
156	Ubiquitination	LGQFWTTKAFLPRML CHHHHHHHHHHHHHH	29.75	21890473
157	Ubiquitination	GQFWTTKAFLPRMLE HHHHHHHHHHHHHHH	14.76	33845483
180	Phosphorylation	LNSVLALSAIPGAID CCCHHHHHCCCCHHH	20.67	22210691
190	Phosphorylation	PGAIDYCTSKASAFA CCHHHHHCCHHHHHH	27.34	22210691
191	Phosphorylation	GAIDYCTSKASAFAF CHHHHHCCHHHHHHH	23.74	22210691
214	Ubiquitination	LDCPGVSATTVLPFH CCCCCCCEEEEECCC	12.60	21890473
242 (in isoform 1)	Ubiquitination	-	46.73	21890473
242	Ubiquitination	PNLFPPLKPETVARR CCCCCCCCHHHHHHH	46.73	22817900
299	Ubiquitination	YTCMNTFKGRT---- EEECCCCCCCC----	45.50	21890473
299	Ubiquitination	YTCMNTFKGRT---- EEECCCCCCCC----	45.50	32015554
299 (in isoform 1)	Ubiquitination	-	45.50	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHRS3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHRS3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHRS3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DHRS3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00162: Vitamin A