UTP6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UTP6_HUMAN
• UniProt AC: Q9NYH9
• Protein Name: U3 small nucleolar RNA-associated protein 6 homolog
• Gene Name: UTP6
• Organism: Homo sapiens (Human).
• Sequence Length: 597
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Involved in nucleolar processing of pre-18S ribosomal RNA..
• Protein Sequence: MAEIIQERIEDRLPELEQLERIGLFSHAEIKAIIKKASDLEYKIQRRTLFKEDFINYVQYEINLLELIQRRRTRIGYSFKKDEIENSIVHRVQGVFQRASAKWKDDVQLWLSYVAFCKKWATKTRLSKVFSAMLAIHSNKPALWIMAAKWEMEDRLSSESARQLFLRALRFHPECPKLYKEYFRMELMHAEKLRKEKEEFEKASMDVENPDYSEEILKGELAWIIYKNSVSIIKGAEFHVSLLSIAQLFDFAKDLQKEIYDDLQALHTDDPLTWDYVARRELEIESQTEEQPTTKQAKAVEVGRKEERCCAVYEEAVKTLPTEAMWKCYITFCLERFTKKSNSGFLRGKRLERTMTVFRKAHELKLLSECQYKQLSVSLLCYNFLREALEVAVAGTELFRDSGTMWQLKLQVLIESKSPDIAMLFEEAFVHLKPQVCLPLWISWAEWSEGAKSQEDTEAVFKKALLAVIGADSVTLKNKYLDWAYRSGGYKKARAVFKSLQESRPFSVDFFRKMIQFEKEQESCNMANIREYYERALREFGSADSDLWMDYMKEELNHPLGRPENCGQIYWRAMKMLQGESAEAFVAKHAMHQTGHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Methylation	IQERIEDRLPELEQL HHHHHHHHCHHHHHH	39.08	-
26	Phosphorylation	LERIGLFSHAEIKAI HHHHCCCCHHHHHHH	27.16	27251275
31	Ubiquitination	LFSHAEIKAIIKKAS CCCHHHHHHHHHHHH	25.66	29967540
43	Ubiquitination	KASDLEYKIQRRTLF HHHHCHHHHHHHHHC	24.00	29967540
80	Ubiquitination	TRIGYSFKKDEIENS HCCCCCCCHHHHHHH	54.07	22817900
81	Ubiquitination	RIGYSFKKDEIENSI CCCCCCCHHHHHHHH	59.59	21906983
113	Phosphorylation	DVQLWLSYVAFCKKW HHHHHHHHHHHHHHH	8.14	24114839
138	Phosphorylation	SAMLAIHSNKPALWI HHHHHHHCCCCCHHH	40.20	-
174	Ubiquitination	RALRFHPECPKLYKE HHHHHCCCCHHHHHH	55.68	21963094
177	Ubiquitination	RFHPECPKLYKEYFR HHCCCCHHHHHHHHH	75.90	22817900
177	Acetylation	RFHPECPKLYKEYFR HHCCCCHHHHHHHHH	75.90	26051181
180	Acetylation	PECPKLYKEYFRMEL CCCHHHHHHHHHHHH	57.27	26051181
180	Ubiquitination	PECPKLYKEYFRMEL CCCHHHHHHHHHHHH	57.27	22817900
182	Phosphorylation	CPKLYKEYFRMELMH CHHHHHHHHHHHHHH	7.73	29759185
192	Ubiquitination	MELMHAEKLRKEKEE HHHHHHHHHHHHHHH	55.14	-
197	Ubiquitination	AEKLRKEKEEFEKAS HHHHHHHHHHHHHHH	66.63	29967540
202	Ubiquitination	KEKEEFEKASMDVEN HHHHHHHHHHCCCCC	51.59	29967540
204	Phosphorylation	KEEFEKASMDVENPD HHHHHHHHCCCCCCC	26.95	25159151
231	Phosphorylation	IIYKNSVSIIKGAEF EEEECCCEECCCCHH	20.58	24719451
257	Ubiquitination	DFAKDLQKEIYDDLQ HHHHHHHHHHHHHHH	54.07	29967540
260	Phosphorylation	KDLQKEIYDDLQALH HHHHHHHHHHHHHHC	12.42	22817900
276	Phosphorylation	DDPLTWDYVARRELE CCCCCHHHHHHHHHH	6.38	22817900
286	Phosphorylation	RRELEIESQTEEQPT HHHHHHCCCCCCCCC	48.33	25159151
288	Phosphorylation	ELEIESQTEEQPTTK HHHHCCCCCCCCCCH	51.25	25262027
293	Phosphorylation	SQTEEQPTTKQAKAV CCCCCCCCCHHHHHH	46.44	27251275
294	Phosphorylation	QTEEQPTTKQAKAVE CCCCCCCCHHHHHHH	28.04	27251275
295	Ubiquitination	TEEQPTTKQAKAVEV CCCCCCCHHHHHHHH	51.22	21906983
298	Ubiquitination	QPTTKQAKAVEVGRK CCCCHHHHHHHHCCC	50.93	29967540
313	Phosphorylation	EERCCAVYEEAVKTL HHHHHHHHHHHHHHC	6.90	25839225
318	Ubiquitination	AVYEEAVKTLPTEAM HHHHHHHHHCCHHHH	51.93	29967540
339	Acetylation	FCLERFTKKSNSGFL HHHHHHHCCCCCCCC	52.04	91073
340	Acetylation	CLERFTKKSNSGFLR HHHHHHCCCCCCCCC	52.38	91077
340	Ubiquitination	CLERFTKKSNSGFLR HHHHHHCCCCCCCCC	52.38	29967540
341	Ubiquitination	LERFTKKSNSGFLRG HHHHHCCCCCCCCCC	37.47	22817900
342	Ubiquitination	ERFTKKSNSGFLRGK HHHHCCCCCCCCCCH	55.84	21890473
343	Phosphorylation	RFTKKSNSGFLRGKR HHHCCCCCCCCCCHH	37.70	29457462
356	Ubiquitination	KRLERTMTVFRKAHE HHHHHHHHHHHHHHH	18.84	22817900
356	Phosphorylation	KRLERTMTVFRKAHE HHHHHHHHHHHHHHH	18.84	24719451
358	Ubiquitination	LERTMTVFRKAHELK HHHHHHHHHHHHHHH	4.95	21890473
365	Ubiquitination	FRKAHELKLLSECQY HHHHHHHHCHHHCCC	44.38	29967540
377	Ubiquitination	CQYKQLSVSLLCYNF CCCHHHHHHHHHHHH	6.76	21890473
402	Phosphorylation	GTELFRDSGTMWQLK CCHHHHCCCCCEEEE	31.72	28674151
404	Phosphorylation	ELFRDSGTMWQLKLQ HHHHCCCCCEEEEEH	21.13	28674151
462	Ubiquitination	EDTEAVFKKALLAVI HHHHHHHHHHHHHHH	30.45	22817900
462	Acetylation	EDTEAVFKKALLAVI HHHHHHHHHHHHHHH	30.45	26051181
463	Ubiquitination	DTEAVFKKALLAVIG HHHHHHHHHHHHHHC	32.57	21890473
473	Phosphorylation	LAVIGADSVTLKNKY HHHHCCCCEECCHHH	19.23	-
477	Ubiquitination	GADSVTLKNKYLDWA CCCCEECCHHHHHHH	41.87	22817900
479	Acetylation	DSVTLKNKYLDWAYR CCEECCHHHHHHHHH	45.67	25825284
479	Ubiquitination	DSVTLKNKYLDWAYR CCEECCHHHHHHHHH	45.67	22817900
480	Phosphorylation	SVTLKNKYLDWAYRS CEECCHHHHHHHHHC	21.20	22817900
485	Phosphorylation	NKYLDWAYRSGGYKK HHHHHHHHHCCCHHH	10.89	22817900
487	Phosphorylation	YLDWAYRSGGYKKAR HHHHHHHCCCHHHHH	24.72	24719451
490	Phosphorylation	WAYRSGGYKKARAVF HHHHCCCHHHHHHHH	16.91	24719451
498	Ubiquitination	KKARAVFKSLQESRP HHHHHHHHHHHHHCC	43.59	22817900
499	Phosphorylation	KARAVFKSLQESRPF HHHHHHHHHHHHCCC	24.66	21406692
503	Phosphorylation	VFKSLQESRPFSVDF HHHHHHHHCCCCHHH	32.09	21406692
507	Phosphorylation	LQESRPFSVDFFRKM HHHHCCCCHHHHHHH	24.37	21406692
513	Ubiquitination	FSVDFFRKMIQFEKE CCHHHHHHHHHHHHH	34.89	29967540
519	Ubiquitination	RKMIQFEKEQESCNM HHHHHHHHHHHCCCC	67.02	29967540
575	Ubiquitination	QIYWRAMKMLQGESA HHHHHHHHHHCCCCH	35.16	29967540
581	Phosphorylation	MKMLQGESAEAFVAK HHHHCCCCHHHHHHH	37.93	-
588	Ubiquitination	SAEAFVAKHAMHQTG CHHHHHHHHHHHHCC	26.96	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UTP6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UTP6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UTP6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KXDL1_HUMAN	KXD1	physical	16189514
RHXF2_HUMAN	RHOXF2	physical	16189514
LRSM1_HUMAN	LRSAM1	physical	28514442
GBP1_HUMAN	GBP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.