KXDL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KXDL1_HUMAN
• UniProt AC: Q9BQD3
• Protein Name: KxDL motif-containing protein 1
• Gene Name: KXD1
• Organism: Homo sapiens (Human).
• Sequence Length: 176
• Subcellular Localization: Lysosome membrane .
• Protein Description: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. [PubMed: 25898167 May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity]
• Protein Sequence: MDLPDSASRVFCGRILSMVNTDDVNAIILAQKNMLDRFEKTNEMLLNFNNLSSARLQQMSERFLHHTRTLVEMKRDLDSIFRRIRTLKGKLARQHPEAFSHIPEASFLEEEDEDPIPPSTTTTIATSEQSTGSCDTSPDTVSPSLSPGFEDLSHVQPGSPAINGRSQTDDEEMTGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDLPDSAS -------CCCCCHHH	12.31	22814378
40	Ubiquitination	NMLDRFEKTNEMLLN CCHHHHHHHHHHHHH	54.67	-
159	Phosphorylation	LSHVQPGSPAINGRS CCCCCCCCCCCCCCC	20.17	26074081
166	Phosphorylation	SPAINGRSQTDDEEM CCCCCCCCCCCCCCC	38.54	30576142
168	Phosphorylation	AINGRSQTDDEEMTG CCCCCCCCCCCCCCC	46.82	30576142
174	Phosphorylation	QTDDEEMTGE----- CCCCCCCCCC-----	41.25	28176443

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KXDL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KXDL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KXDL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MLP3B_HUMAN	MAP1LC3B	physical	16189514
CEP19_HUMAN	CEP19	physical	16189514
NUD18_HUMAN	NUDT18	physical	16189514
ING5_HUMAN	ING5	physical	16189514
CCD33_HUMAN	CCDC33	physical	16189514
IFT20_HUMAN	IFT20	physical	16189514
RN183_HUMAN	RNF183	physical	16189514
LNX1_HUMAN	LNX1	physical	16189514
CC185_HUMAN	CCDC185	physical	16189514
CEP63_HUMAN	CEP63	physical	16189514
MLP3B_HUMAN	MAP1LC3B	physical	25416956
MLP3A_HUMAN	MAP1LC3A	physical	25416956
CEP19_HUMAN	CEP19	physical	25416956
IFT20_HUMAN	IFT20	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
LRC45_HUMAN	LRRC45	physical	25416956
CD046_HUMAN	C4orf46	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.