LRC45_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC45_HUMAN
• UniProt AC: Q96CN5
• Protein Name: Leucine-rich repeat-containing protein 45
• Gene Name: LRRC45
• Organism: Homo sapiens (Human).
• Sequence Length: 670
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to the proteinaceous linker between the proximal ends of the centrioles.
• Protein Description: Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion..
• Protein Sequence: MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQASPVRTLSPPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEEFRRSYSRLCRE -CHHHHHHHHHHHHH	24.17	17081983
8	Phosphorylation	MEEFRRSYSRLCRES CHHHHHHHHHHHHHH	8.94	17081983
9	Phosphorylation	EEFRRSYSRLCRESG HHHHHHHHHHHHHHC	21.74	17081983
172	Phosphorylation	ALALKGNTTLQQLDL HHHHCCCCCHHHCCC	37.24	-
173	Phosphorylation	LALKGNTTLQQLDLR HHHCCCCCHHHCCCC	26.94	-
328	Phosphorylation	DLGELLATAEQEQLS HHHHHHHHHHHHHHC	30.60	30301811
335	Phosphorylation	TAEQEQLSLSQRQAK HHHHHHHCCHHHHHH	26.18	28450419
337	Phosphorylation	EQEQLSLSQRQAKEL HHHHHCCHHHHHHHH	21.68	28450419
368	Ubiquitination	DLSAANEKNLLLQNQ HHHHHHHHHHHHHHH	53.34	29967540
399	Phosphorylation	QTRQEMTSMSAELKM HHHHHHHHCCHHHHH	14.94	24505115
401	Phosphorylation	RQEMTSMSAELKMRA HHHHHHCCHHHHHHH	20.54	24505115
405	Ubiquitination	TSMSAELKMRAIQAE HHCCHHHHHHHHHHH	20.18	29967540
425	Phosphorylation	EKRRCRQSLEDSESL HHHHHHHHHHHHHHH	17.86	24719451
441	Phosphorylation	IKEVEHMTRHLEESE HHHHHHHHHHHHHHH	19.49	-
478	Phosphorylation	RVKAAALSERGQAEE HHHHHHHHHHCHHHH	22.11	23312004
648	Phosphorylation	DEEAQRASFLQNAVL CHHHHHHHHHHHHHH	28.78	22199227
657	Phosphorylation	LQNAVLAYVQASPVR HHHHHHHHHHCCCCC	6.74	22199227
661	Phosphorylation	VLAYVQASPVRTLSP HHHHHHCCCCCCCCC	13.56	24035387
665	Phosphorylation	VQASPVRTLSPPK-- HHCCCCCCCCCCC--	31.64	22199227
667	Phosphorylation	ASPVRTLSPPK---- CCCCCCCCCCC----	38.24	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
661	S	Phosphorylation	Kinase	NEK2	P51955	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC45_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC45_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S100P_HUMAN	S100P	physical	22939629
KXDL1_HUMAN	KXD1	physical	21516116
UPP1_HUMAN	UPP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.