| UniProt ID | UPP1_HUMAN | |
|---|---|---|
| UniProt AC | Q16831 | |
| Protein Name | Uridine phosphorylase 1 | |
| Gene Name | UPP1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 310 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. [PubMed: 7488099 The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.] | |
| Protein Sequence | MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Acetylation | ATGANAEKAESHNDC CCCCCHHHHHHCCCC | 55.85 | 23236377 | |
| 20 | Methylation | SHNDCPVRLLNPNIA HCCCCCCHHCCCCHH | 20.71 | 115386701 | |
| 28 | Ubiquitination | LLNPNIAKMKEDILY HCCCCHHHHHHHHHH | 46.86 | - | |
| 35 | Phosphorylation | KMKEDILYHFNLTTS HHHHHHHHHEECCCC | 12.52 | 27259358 | |
| 61 | Phosphorylation | KFVCVGGSPSRMKAF EEEEECCCHHHHHHH | 17.49 | 19664994 | |
| 63 | Phosphorylation | VCVGGSPSRMKAFIR EEECCCHHHHHHHHH | 46.86 | 29255136 | |
| 174 | Ubiquitination | FEQIVLGKRVIRKTD HHHHHCCCCEEECCC | 39.05 | - | |
| 198 | Phosphorylation | LLCSAELSEFTTVVG HHCHHHHHHCEEEEC | 23.36 | 22468782 | |
| 201 | Phosphorylation | SAELSEFTTVVGNTM HHHHHHCEEEECCEE | 18.03 | 22468782 | |
| 214 | Phosphorylation | TMCTLDFYEGQGRLD EEEEEEECCCCCCCC | 20.86 | 22468782 | |
| 230 | Ubiquitination | ALCSYTEKDKQAYLE EEEECCHHHHHHHHH | 63.53 | - | |
| 232 | Ubiquitination | CSYTEKDKQAYLEAA EECCHHHHHHHHHHH | 48.14 | 2190698 | |
| 232 (in isoform 1) | Ubiquitination | - | 48.14 | 21906983 | |
| 282 | Phosphorylation | RLEGDQISSPRNVLS HHCCCCCCCHHHHHH | 28.76 | 24719451 | |
| 283 | Phosphorylation | LEGDQISSPRNVLSE HCCCCCCCHHHHHHH | 29.52 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UPP1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UPP1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UPP1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| VIME_HUMAN | VIM | physical | 11278417 | |
| WBP2_HUMAN | WBP2 | physical | 22939629 | |
| WIPI3_HUMAN | WDR45B | physical | 22939629 | |
| YRDC_HUMAN | YRDC | physical | 22939629 |
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB00544 | Fluorouracil |
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