CC185_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC185_HUMAN
• UniProt AC: Q8N715
• Protein Name: Coiled-coil domain-containing protein 185
• Gene Name: CCDC185
• Organism: Homo sapiens (Human).
• Sequence Length: 623
• Protein Sequence: MAGFSHFSQPPYRDLWEPPRPGGERESTQRLGGQRSGADSTACSRAGTPGAESEAGACWLHPHCSFTPRPRRRGCSDSLRGSRSLSDVARRPLERSRKHRPRSRRLEDAWGETGTKPRPAWQPQTQLPPQRPQPCPHYPLAQGDSPPPCPGGAGTPLSGTFRVEKAQGGDQWAVPLGRHLGRWSPSSVPSERSSVPSQKFKRHSACVCAQKRDSSDQVESLASRDSQPLASSKEMRSPHTQVLKSKLEEVVVSSQDQQIVALVLTRLKKAQRIRELQQQAAKAWEELKRSDQKVQMTLERERRLLLRQSQEQWQEKEQRKTLQSPEQRGLRRDSQRKNVPPGESRWKEQPEDQESPRQEKLEKARAQAEHRKQCQVRRLREQEKMLRNLREQHSLQLQRRLVEACRKRHLHAVEGQKKVQDTNLSSLINYQARKVLMDCQAKAEELLRQLSLEQSFQRSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQARSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEKCHIEGIKEAIKKKEQRVQHISQGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQLRACQQNRGY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	LRGSRSLSDVARRPL CCCCCCHHHHHHCHH		22210691
186	Phosphorylation	HLGRWSPSSVPSERS CCCCCCCCCCCCCCC		24114839
190	Phosphorylation	WSPSSVPSERSSVPS CCCCCCCCCCCCCCC		26853621
193	Phosphorylation	SSVPSERSSVPSQKF CCCCCCCCCCCCHHH		-
194	Phosphorylation	SVPSERSSVPSQKFK CCCCCCCCCCCHHHH		-
197	Phosphorylation	SERSSVPSQKFKRHS CCCCCCCCHHHHHCC		-
324	Phosphorylation	EQRKTLQSPEQRGLR HHHHHCCCHHHHCCC		-
334	Phosphorylation	QRGLRRDSQRKNVPP HHCCCCHHHHCCCCC		-
384	Ubiquitination	RRLREQEKMLRNLRE HHHHHHHHHHHHHHH		-
426	Phosphorylation	VQDTNLSSLINYQAR CCCCCHHHHHHHHHH		-
515	Dimethylation	ELADEKIRQARSHVH HHHHHHHHHHHHHCC		-
515	Methylation	ELADEKIRQARSHVH HHHHHHHHHHHHHCC		-
528	Sumoylation	VHKTTRDKVQHLREL CCHHHHHHHHHHHHH		-
528	Sumoylation	VHKTTRDKVQHLREL CCHHHHHHHHHHHHH		25218447
568	Ubiquitination	IKEAIKKKEQRVQHI HHHHHHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC185_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC185_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC185_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LURA1_HUMAN	LURAP1	physical	16189514
KR107_HUMAN	KRTAP10-7	physical	25416956
LIGO1_HUMAN	LINGO1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.