dbPTM

MLP3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MLP3B_HUMAN
UniProt AC	Q9GZQ8
Protein Name	Microtubule-associated proteins 1A/1B light chain 3B
Gene Name	MAP1LC3B
Organism	Homo sapiens (Human).
Sequence Length	125
Subcellular Localization	Cytoplasm, cytoskeleton. Endomembrane system Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane Lipid-anchor. Cytoplasmic vesicle, autophagosome . LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary
Protein Description	Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway..
Protein Sequence	MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MPSEKTFKQRRT ---CCCHHHHHHHHC	64.70	-
6	Phosphorylation	--MPSEKTFKQRRTF --CCCHHHHHHHHCH	31.82	20398630
12	Phosphorylation	KTFKQRRTFEQRVED HHHHHHHCHHHHHHH	33.44	-
21	Methylation	EQRVEDVRLIREQHP HHHHHHHHHHHHHCC	36.40	-
29	Phosphorylation	LIREQHPTKIPVIIE HHHHHCCCCCCEEEE	39.21	22817900
30	Ubiquitination	IREQHPTKIPVIIER HHHHCCCCCCEEEEE	49.84	-
30	Acetylation	IREQHPTKIPVIIER HHHHCCCCCCEEEEE	49.84	25953088
30	Malonylation	IREQHPTKIPVIIER HHHHCCCCCCEEEEE	49.84	26320211
42	Ubiquitination	IERYKGEKQLPVLDK EEECCCCCCCCCCCC	66.84	-
42	2-Hydroxyisobutyrylation	IERYKGEKQLPVLDK EEECCCCCCCCCCCC	66.84	-
49	Ubiquitination	KQLPVLDKTKFLVPD CCCCCCCCCCCCCCC	49.83	-
50	Phosphorylation	QLPVLDKTKFLVPDH CCCCCCCCCCCCCCC	27.05	-
51	Ubiquitination	LPVLDKTKFLVPDHV CCCCCCCCCCCCCCC	42.30	21890473
51	2-Hydroxyisobutyrylation	LPVLDKTKFLVPDHV CCCCCCCCCCCCCCC	42.30	-
51	Acetylation	LPVLDKTKFLVPDHV CCCCCCCCCCCCCCC	42.30	25953088
65	Ubiquitination	VNMSELIKIIRRRLQ CCHHHHHHHHHHHHC	44.71	21890473
120	Phosphatidylethanolamine amidation	YASQETFGMKLSV-- EECCCCCCCCCCC--	21.53	15187094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
6	T	Phosphorylation	Kinase	PRKACA	P27791	GPS
12	T	Phosphorylation	Kinase	PKA	-	Uniprot
29	T	Phosphorylation	Kinase	PRKACA	P27791	GPS
50	T	Phosphorylation	Kinase	PKCZ	Q05513	PSP
50	T	Phosphorylation	Kinase	NEK9	Q8TD19	PSP
50	T	Phosphorylation	Kinase	MST2	Q13188	PSP
50	T	Phosphorylation	Kinase	MST1	Q13043	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF6	Q9Y4K3	PMID:30806153

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
12	T	Phosphorylation		15187094
Phosphorylation at Thr-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE) (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MLP3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LC7L2_HUMAN	LUC7L2	physical	16169070
ATG4B_HUMAN	ATG4B	physical	16169070
KBTB7_HUMAN	KBTBD7	physical	16169070
SQSTM_HUMAN	SQSTM1	physical	16169070
MAP1B_HUMAN	MAP1B	physical	20562859
FYCO1_HUMAN	FYCO1	physical	20562859
MAP1A_HUMAN	MAP1A	physical	20562859
DOCK1_HUMAN	DOCK1	physical	20562859
STK4_HUMAN	STK4	physical	20562859
RASF5_HUMAN	RASSF5	physical	20562859
SQSTM_HUMAN	SQSTM1	physical	20562859
ATG7_HUMAN	ATG7	physical	20562859
ATG4B_HUMAN	ATG4B	physical	20562859
STK3_HUMAN	STK3	physical	20562859
NIPS2_HUMAN	GBAS	physical	20562859
A16L1_HUMAN	ATG16L1	physical	20562859
MLP3A_HUMAN	MAP1LC3A	physical	20562859
NIPS1_HUMAN	NIPSNAP1	physical	20562859
EPN4_HUMAN	CLINT1	physical	20562859
TM160_HUMAN	TMEM160	physical	20562859
ECHB_HUMAN	HADHB	physical	20562859
ECHA_HUMAN	HADHA	physical	20562859
ATG3_HUMAN	ATG3	physical	20562859
KPCI_HUMAN	PRKCI	physical	20562859
ATG5_HUMAN	ATG5	physical	20562859
KEAP1_HUMAN	KEAP1	physical	20562859
GBRAP_HUMAN	GABARAP	physical	20562859
MOFA1_HUMAN	MRFAP1	physical	21900206
ADDA_HUMAN	ADD1	physical	21900206
THAP7_HUMAN	THAP7	physical	21900206
EPS8_HUMAN	EPS8	physical	21900206
RETR2_HUMAN	FAM134A	physical	21900206
CCSE2_HUMAN	CCSER2	physical	21900206
RIPR1_HUMAN	FAM65A	physical	21900206
EED_HUMAN	EED	physical	21900206
SNF5_HUMAN	SMARCB1	physical	21900206
TMOD3_HUMAN	TMOD3	physical	21900206
KLHL5_HUMAN	KLHL5	physical	21900206
SQSTM_HUMAN	SQSTM1	physical	21900206
AAMP_HUMAN	AAMP	physical	21900206
DNM3B_HUMAN	DNMT3B	physical	21900206
CASP8_HUMAN	CASP8	physical	21900206
LC7L2_HUMAN	LUC7L2	physical	21900206
DREB_HUMAN	DBN1	physical	21900206
BRD3_HUMAN	BRD3	physical	21900206
MYBB_HUMAN	MYBL2	physical	21900206
ARFG1_HUMAN	ARFGAP1	physical	21900206
JIP4_HUMAN	SPAG9	physical	21900206
ADNP_HUMAN	ADNP	physical	21900206
SEM1_HUMAN	SHFM1	physical	21900206
SAFB1_HUMAN	SAFB	physical	21900206
ACBP_HUMAN	DBI	physical	21900206
MKRN1_HUMAN	MKRN1	physical	21900206
KBTB7_HUMAN	KBTBD7	physical	21900206
RLA1_HUMAN	RPLP1	physical	21900206
TAF7_HUMAN	TAF7	physical	21900206
CLCA_HUMAN	CLTA	physical	21900206
RPGP1_HUMAN	RAP1GAP	physical	21900206
ATG4B_HUMAN	ATG4B	physical	21900206
TBC25_HUMAN	TBC1D25	physical	21383079
OPTN_HUMAN	OPTN	physical	21617041
TBCD9_HUMAN	TBC1D9	physical	22354992
TBC9B_HUMAN	TBC1D9B	physical	22354992
TBC17_HUMAN	TBC1D17	physical	22354992
TBCD5_HUMAN	TBC1D5	physical	22354992
ULK1_HUMAN	ULK1	physical	23043107
ATG13_HUMAN	ATG13	physical	23043107
FYCO1_HUMAN	FYCO1	physical	23043107
SQSTM_HUMAN	SQSTM1	physical	23333919
ATG4B_HUMAN	ATG4B	physical	20010802
ATG4A_HUMAN	ATG4A	physical	20010802
SQSTM_HUMAN	SQSTM1	physical	20010802
BNI3L_HUMAN	BNIP3L	physical	20010802
OPTN_HUMAN	OPTN	physical	23805866
MK15_HUMAN	MAPK15	physical	22948227
NH2L1_HUMAN	NHP2L1	physical	21988832
SQSTM_HUMAN	SQSTM1	physical	22434781
BNIP3_HUMAN	BNIP3	physical	23209295
UB2L3_HUMAN	UBE2L3	physical	24566975
CACB3_RAT	Cacnb3	physical	24566975
CAC1B_HUMAN	CACNA1B	physical	24566975
ATG4B_HUMAN	ATG4B	physical	24023838
ATG7_HUMAN	ATG7	physical	24023838
ATG3_HUMAN	ATG3	physical	24023838
TAXB1_HUMAN	TAX1BP1	physical	23209807
SQSTM_HUMAN	SQSTM1	physical	24582747
GBRL2_HUMAN	GABARAPL2	physical	24582747
SQSTM_HUMAN	SQSTM1	physical	25007327
P53_HUMAN	TP53	physical	25144556
FUND1_HUMAN	FUNDC1	physical	25416956
TBK1_HUMAN	TBK1	physical	21617041
KBTB7_HUMAN	KBTBD7	physical	25684205
KBTB6_HUMAN	KBTBD6	physical	25684205
CUL3_HUMAN	CUL3	physical	25684205
PML_HUMAN	PML	physical	25419843
RO52_HUMAN	TRIM21	physical	26347139
CACO2_HUMAN	CALCOCO2	physical	25771791
FLCN_HUMAN	FLCN	physical	25126726
SQSTM_HUMAN	SQSTM1	physical	26413874
NEDD4_HUMAN	NEDD4	physical	28085563
SQSTM_HUMAN	SQSTM1	physical	28085563
UBC_HUMAN	UBC	physical	28404643
LMNB1_HUMAN	LMNB1	physical	26524528
SQSTM_HUMAN	SQSTM1	physical	26524528

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MLP3B_HUMAN

Related Literatures of Post-Translational Modification

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