RETR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RETR2_HUMAN
• UniProt AC: Q8NC44
• Protein Name: Reticulophagy regulator 2 {ECO:0000312|HGNC:HGNC:28450}
• Gene Name: RETREG2 {ECO:0000312|HGNC:HGNC:28450}
• Organism: Homo sapiens (Human).
• Sequence Length: 543
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MASGGGGGNTGAGGGPGMGLSLGLGLGLSLGMSEATSEAEEEAATAEAVGRLATTLWLRLRGWEAVLAAAQRLLVWEKPLHSLVTAAALNGLFWLLSSSSLRPFFLLSVSLLAYFLLDLWQPRFLPDVSASSPEEPHSDSEGAGSGARPHLLSVPELCRYLAESWLTFQIHLQELLQYKRQNPAQFCVRVCSGCAVLAVLGHYVPGIMISYIVLLSILLWPLVVYHELIQRMYTRLEPLLMQLDYSMKAEANALHHKHDKRKRQGKNAPPGGDEPLAETESESEAELAGFSPVVDVKKTALALAITDSELSDEEASILESGGFSVSRATTPQLTDVSEDLDQQSLPSEPEETLSRDLGEGEEGELAPPEDLLGRPQALSRQALDSEEEEEDVAAKETLLRLSSPLHFVNTHFNGAGSPPDGVKCSPGGPVETLSPETVSGGLTALPGTLSPPLCLVGSDPAPSPSILPPVPQDSPQPLPAPEEEEALTTEDFELLDQGELEQLNAELGLEPETPPKPPDAPPLGPDIHSLVQSDQEAQAVAEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
129	Phosphorylation	PRFLPDVSASSPEEP HHCCCCCCCCCCCCC		29255136
131	Phosphorylation	FLPDVSASSPEEPHS CCCCCCCCCCCCCCC		30206219
132	Phosphorylation	LPDVSASSPEEPHSD CCCCCCCCCCCCCCC		25849741
138	Phosphorylation	SSPEEPHSDSEGAGS CCCCCCCCCCCCCCC		23401153
140	Phosphorylation	PEEPHSDSEGAGSGA CCCCCCCCCCCCCCC		30266825
145	Phosphorylation	SDSEGAGSGARPHLL CCCCCCCCCCCHHHH		27794612
233	Phosphorylation	HELIQRMYTRLEPLL HHHHHHHHHHHHHHH		22210691
234	Phosphorylation	ELIQRMYTRLEPLLM HHHHHHHHHHHHHHH		22210691
245	Phosphorylation	PLLMQLDYSMKAEAN HHHHHCHHHHHHHHH		-
279	Phosphorylation	GDEPLAETESESEAE CCCCCCCCCCHHHHH		23927012
281	Phosphorylation	EPLAETESESEAELA CCCCCCCCHHHHHHC		23927012
283	Phosphorylation	LAETESESEAELAGF CCCCCCHHHHHHCCC		23927012
291	Phosphorylation	EAELAGFSPVVDVKK HHHHCCCCCCCCHHH		30266825
299	Phosphorylation	PVVDVKKTALALAIT CCCCHHHHHHHHHHC		27732954
306	Phosphorylation	TALALAITDSELSDE HHHHHHHCCCCCCHH		27732954
308	Phosphorylation	LALAITDSELSDEEA HHHHHCCCCCCHHHH		30624053
311	Phosphorylation	AITDSELSDEEASIL HHCCCCCCHHHHHHH		28102081
316	Phosphorylation	ELSDEEASILESGGF CCCHHHHHHHHHCCC		27732954
320	Phosphorylation	EEASILESGGFSVSR HHHHHHHHCCCCCCC		27732954
324	Phosphorylation	ILESGGFSVSRATTP HHHHCCCCCCCCCCC		27732954
326	Phosphorylation	ESGGFSVSRATTPQL HHCCCCCCCCCCCCC		27732954
329	Phosphorylation	GFSVSRATTPQLTDV CCCCCCCCCCCCCCC		30266825
330	Phosphorylation	FSVSRATTPQLTDVS CCCCCCCCCCCCCCC		30266825
334	Phosphorylation	RATTPQLTDVSEDLD CCCCCCCCCCCHHHH		30278072
337	Phosphorylation	TPQLTDVSEDLDQQS CCCCCCCCHHHHHCC		30266825
344	Phosphorylation	SEDLDQQSLPSEPEE CHHHHHCCCCCCCHH		30266825
347	Phosphorylation	LDQQSLPSEPEETLS HHHCCCCCCCHHHHH		23927012
352	Phosphorylation	LPSEPEETLSRDLGE CCCCCHHHHHCCCCC		25850435
354	Phosphorylation	SEPEETLSRDLGEGE CCCHHHHHCCCCCCC		25850435
379	Phosphorylation	LGRPQALSRQALDSE CCCHHHHHHHHCCCH		30266825
385	Phosphorylation	LSRQALDSEEEEEDV HHHHHCCCHHHHHHH		29255136
397	Phosphorylation	EDVAAKETLLRLSSP HHHHHHHHHHHHCCC		23403867
402	Phosphorylation	KETLLRLSSPLHFVN HHHHHHHCCCCCEEC		25849741
403	Phosphorylation	ETLLRLSSPLHFVNT HHHHHHCCCCCEECC		17001009
410	Phosphorylation	SPLHFVNTHFNGAGS CCCCEECCCCCCCCC		30108239
417	Phosphorylation	THFNGAGSPPDGVKC CCCCCCCCCCCCCCC		22199227
513	Phosphorylation	ELGLEPETPPKPPDA HHCCCCCCCCCCCCC		26074081
529	Phosphorylation	PLGPDIHSLVQSDQE CCCCCHHHHHCCHHH		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RETR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RETR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RETR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHD3_HUMAN	CHD3	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
ATPA_HUMAN	ATP5A1	physical	26496610
AT5F1_HUMAN	ATP5F1	physical	26496610
ATP5J_HUMAN	ATP5J	physical	26496610
ATPO_HUMAN	ATP5O	physical	26496610
IF5A1_HUMAN	EIF5A	physical	26496610
GOGA3_HUMAN	GOLGA3	physical	26496610
ABCD3_HUMAN	ABCD3	physical	26496610
PRDX2_HUMAN	PRDX2	physical	26496610
RM33_HUMAN	MRPL33	physical	26496610
CHD1L_HUMAN	CHD1L	physical	26496610
ATP5H_HUMAN	ATP5H	physical	26496610
HPSE_HUMAN	HPSE	physical	26496610
S27A2_HUMAN	SLC27A2	physical	26496610
TPC_HUMAN	SLC25A19	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.