ABCD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABCD3_HUMAN
• UniProt AC: P28288
• Protein Name: ATP-binding cassette sub-family D member 3
• Gene Name: ABCD3
• Organism: Homo sapiens (Human).
• Sequence Length: 659
• Subcellular Localization: Peroxisome membrane ; Multi-pass membrane protein .
• Protein Description: Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. [PubMed: 25168382 The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity]
• Protein Sequence: MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAAFSKYLTARN ---CCHHHHHHHHCC	18.70	20068231
6	2-Hydroxyisobutyrylation	--MAAFSKYLTARNS --CCHHHHHHHHCCC	37.51	-
6	Acetylation	--MAAFSKYLTARNS --CCHHHHHHHHCCC	37.51	25825284
6	Ubiquitination	--MAAFSKYLTARNS --CCHHHHHHHHCCC	37.51	24816145
7	Phosphorylation	-MAAFSKYLTARNSS -CCHHHHHHHHCCCH	14.21	20068231
9	Phosphorylation	AAFSKYLTARNSSLA CHHHHHHHHCCCHHH	22.08	20068231
12	N-linked_Glycosylation	SKYLTARNSSLAGAA HHHHHHCCCHHHHHH	33.22	UniProtKB CARBOHYD
35	Ubiquitination	KRRRALGLHGKKSGK HHHHHHCCCCCCCCC	5.11	21890473
38	2-Hydroxyisobutyrylation	RALGLHGKKSGKPPL HHHCCCCCCCCCCCC	32.77	-
38	Ubiquitination	RALGLHGKKSGKPPL HHHCCCCCCCCCCCC	32.77	22817900
39	Ubiquitination	ALGLHGKKSGKPPLQ HHCCCCCCCCCCCCC	69.87	21906983
39 (in isoform 1)	Ubiquitination	-	69.87	21890473
39 (in isoform 2)	Ubiquitination	-	69.87	21890473
39 (in isoform 3)	Ubiquitination	-	69.87	21890473
40	Phosphorylation	LGLHGKKSGKPPLQN HCCCCCCCCCCCCCC	56.38	30266825
42	Ubiquitination	LHGKKSGKPPLQNNE CCCCCCCCCCCCCCC	51.02	29967540
50	Ubiquitination	PPLQNNEKEGKKERA CCCCCCCCCCHHHHH	74.10	32142685
61	2-Hydroxyisobutyrylation	KERAVVDKVFFSRLI HHHHHHHHHHHHHHH	29.36	-
61	Acetylation	KERAVVDKVFFSRLI HHHHHHHHHHHHHHH	29.36	27452117
61	Ubiquitination	KERAVVDKVFFSRLI HHHHHHHHHHHHHHH	29.36	22817900
61 (in isoform 1)	Ubiquitination	-	29.36	21890473
61 (in isoform 2)	Ubiquitination	-	29.36	21890473
61 (in isoform 3)	Ubiquitination	-	29.36	21890473
65	Phosphorylation	VVDKVFFSRLIQILK HHHHHHHHHHHHHHH	18.08	46267013
72	Ubiquitination	SRLIQILKIMVPRTF HHHHHHHHHHCCHHH	30.31	21963094
78	Ubiquitination	LKIMVPRTFCKETGY HHHHCCHHHCHHHCH	27.58	21963094
85	Phosphorylation	TFCKETGYLVLIAVM HHCHHHCHHHHHHHH	10.89	20068231
85	Ubiquitination	TFCKETGYLVLIAVM HHCHHHCHHHHHHHH	10.89	21890473
87	Ubiquitination	CKETGYLVLIAVMLV CHHHCHHHHHHHHHH	2.47	21963094
93	Ubiquitination	LVLIAVMLVSRTYCD HHHHHHHHHCCCCCC	2.25	21963094
95	Phosphorylation	LIAVMLVSRTYCDVW HHHHHHHCCCCCCEE	18.23	46267019
96	Ubiquitination	IAVMLVSRTYCDVWM HHHHHHCCCCCCEEE	23.41	21963094
101	Ubiquitination	VSRTYCDVWMIQNGT HCCCCCCEEEEECCE	3.14	21963094
106	N-linked_Glycosylation	CDVWMIQNGTLIESG CCEEEEECCEEEECC	34.20	UniProtKB CARBOHYD
145	Phosphorylation	LVNNFLKYGLNELKL HHHHHHHHCCHHHHH	29.06	5051317
151	Acetylation	KYGLNELKLCFRVRL HHCCHHHHHHHHHHH	36.71	26051181
151	Ubiquitination	KYGLNELKLCFRVRL HHCCHHHHHHHHHHH	36.71	21963094
160	Ubiquitination	CFRVRLTKYLYEEYL HHHHHHHHHHHHHHH	37.54	21963094
163	Phosphorylation	VRLTKYLYEEYLQAF HHHHHHHHHHHHHHH	12.01	8273949
167	Ubiquitination	KYLYEEYLQAFTYYK HHHHHHHHHHHHHHH	3.15	21963094
173	Phosphorylation	YLQAFTYYKMGNLDN HHHHHHHHHCCCCCC	7.46	8273961
174	Ubiquitination	LQAFTYYKMGNLDNR HHHHHHHHCCCCCCC	29.89	21963094
175	Ubiquitination	QAFTYYKMGNLDNRI HHHHHHHCCCCCCCC	2.19	21963094
180	Ubiquitination	YKMGNLDNRIANPDQ HHCCCCCCCCCCHHH	40.19	21963094
184	Ubiquitination	NLDNRIANPDQLLTQ CCCCCCCCHHHHHHH	38.01	21963094
187	Ubiquitination	NRIANPDQLLTQDVE CCCCCHHHHHHHHHH	39.36	23000965
192	Ubiquitination	PDQLLTQDVEKFCNS HHHHHHHHHHHHHHH	45.36	23000965
198	Ubiquitination	QDVEKFCNSVVDLYS HHHHHHHHHHHHHHH	40.76	21963094
206	N-linked_Glycosylation	SVVDLYSNLSKPFLD HHHHHHHCCCHHHHH	34.47	UniProtKB CARBOHYD
213	Ubiquitination	NLSKPFLDIVLYIFK CCCHHHHHHHHHHHH	29.36	23000965
216	Ubiquitination	KPFLDIVLYIFKLTS HHHHHHHHHHHHHHH	2.51	23000965
221	Ubiquitination	IVLYIFKLTSAIGAQ HHHHHHHHHHHHCCC	2.97	22817900
223	Ubiquitination	LYIFKLTSAIGAQGP HHHHHHHHHHCCCCC	28.46	22817900
231	Ubiquitination	AIGAQGPASMMAYLV HHCCCCCHHHHHHHH	19.51	21963094
253	Malonylation	RLRRPIGKMTITEQK CCCCCCCCCEEEEEE	33.32	26320211
253	Ubiquitination	RLRRPIGKMTITEQK CCCCCCCCCEEEEEE	33.32	22817900
253 (in isoform 1)	Ubiquitination	-	33.32	21890473
253 (in isoform 2)	Ubiquitination	-	33.32	21890473
260	2-Hydroxyisobutyrylation	KMTITEQKYEGEYRY CCEEEEEEECCEEEE	38.75	-
260	Acetylation	KMTITEQKYEGEYRY CCEEEEEEECCEEEE	38.75	19608861
260	Malonylation	KMTITEQKYEGEYRY CCEEEEEEECCEEEE	38.75	26320211
260	Ubiquitination	KMTITEQKYEGEYRY CCEEEEEEECCEEEE	38.75	32142685
260 (in isoform 1)	Ubiquitination	-	38.75	21890473
260 (in isoform 2)	Ubiquitination	-	38.75	21890473
264	Ubiquitination	TEQKYEGEYRYVNSR EEEEECCEEEEECCE	18.20	21963094
274	Ubiquitination	YVNSRLITNSEEIAF EECCEEECCCCCEEE	36.97	21890473
277	Ubiquitination	SRLITNSEEIAFYNG CEEECCCCCEEEECC	56.33	21963094
284	Ubiquitination	EEIAFYNGNKREKQT CCEEEECCCHHHHHH	29.65	21963094
286	Acetylation	IAFYNGNKREKQTVH EEEECCCHHHHHHHH	64.43	26051181
286	Ubiquitination	IAFYNGNKREKQTVH EEEECCCHHHHHHHH	64.43	23000965
286 (in isoform 1)	Ubiquitination	-	64.43	21890473
289	Malonylation	YNGNKREKQTVHSVF ECCCHHHHHHHHHHH	56.13	26320211
289	Ubiquitination	YNGNKREKQTVHSVF ECCCHHHHHHHHHHH	56.13	23000965
289 (in isoform 2)	Ubiquitination	-	56.13	21890473
295 (in isoform 2)	Ubiquitination	-	3.04	21890473
310	Ubiquitination	LHNFILFRFSMGFID HHHHHHHHHHHHHHH	21.20	23000965
313	Ubiquitination	FILFRFSMGFIDSII HHHHHHHHHHHHHHH	4.70	23000965
326	Ubiquitination	IIAKYLATVVGYLVV HHHHHHHHHHHHHHH	17.09	21963094
332	Ubiquitination	ATVVGYLVVSRPFLD HHHHHHHHHCCCCCC	2.50	21963094
334	Phosphorylation	VVGYLVVSRPFLDLS HHHHHHHCCCCCCCC	27.10	24719451
347	2-Hydroxyisobutyrylation	LSHPRHLKSTHSELL CCCCCHHHHHHHHHH	47.38	-
347	Acetylation	LSHPRHLKSTHSELL CCCCCHHHHHHHHHH	47.38	26051181
347	Ubiquitination	LSHPRHLKSTHSELL CCCCCHHHHHHHHHH	47.38	21963094
347 (in isoform 1)	Ubiquitination	-	47.38	21890473
357	Phosphorylation	HSELLEDYYQSGRML HHHHHHHHHHHHHHH	8.27	110743123
358	Phosphorylation	SELLEDYYQSGRMLL HHHHHHHHHHHHHHH	14.44	110743131
360	Phosphorylation	LLEDYYQSGRMLLRM HHHHHHHHHHHHHHH	16.55	110743139
368	Phosphorylation	GRMLLRMSQALGRIV HHHHHHHHHHHHHHH	13.08	29978859
371	Ubiquitination	LLRMSQALGRIVLAG HHHHHHHHHHHHHCH	3.52	21890473
388	Phosphorylation	MTRLAGFTARITELM HHHHHHHHHHHHHHH	17.70	46267025
392	Phosphorylation	AGFTARITELMQVLK HHHHHHHHHHHHHHH	19.95	25599653
395	Sulfoxidation	TARITELMQVLKDLN HHHHHHHHHHHHHCC	1.79	21406390
399	Acetylation	TELMQVLKDLNHGKY HHHHHHHHHCCCCCC	62.40	19608861
399	Ubiquitination	TELMQVLKDLNHGKY HHHHHHHHHCCCCCC	62.40	21963094
399 (in isoform 1)	Ubiquitination	-	62.40	21890473
405	2-Hydroxyisobutyrylation	LKDLNHGKYERTMVS HHHCCCCCCCCCCCC	36.07	-
405	Acetylation	LKDLNHGKYERTMVS HHHCCCCCCCCCCCC	36.07	26051181
405	Ubiquitination	LKDLNHGKYERTMVS HHHCCCCCCCCCCCC	36.07	21906983
405 (in isoform 1)	Ubiquitination	-	36.07	21890473
406	Ubiquitination	KDLNHGKYERTMVSQ HHCCCCCCCCCCCCC	18.42	21963094
416	Ubiquitination	TMVSQQEKGIEGVQV CCCCCCCCCCCCEEE	61.93	-
423	Ubiquitination	KGIEGVQVIPLIPGA CCCCCEEEEECCCCC	4.52	21963094
425 (in isoform 2)	Ubiquitination	-	25.94	21890473
426	Ubiquitination	EGVQVIPLIPGAGEI CCEEEEECCCCCCEE	5.19	23000965
429	Ubiquitination	QVIPLIPGAGEIIIA EEEECCCCCCEEEEE	38.94	21963094
431	Ubiquitination	IPLIPGAGEIIIADN EECCCCCCEEEEECC	32.33	23000965
433 (in isoform 2)	Ubiquitination	-	2.43	21890473
449	Phosphorylation	FDHVPLATPNGDVLI ECCCCCCCCCCCEEE	25.60	27050516
460	Ubiquitination	DVLIRDLNFEVRSGA CEEEEECCEEEECCC	35.01	22817900
462	Ubiquitination	LIRDLNFEVRSGANV EEEECCEEEECCCEE	35.63	22817900
466 (in isoform 2)	Ubiquitination	-	15.59	21890473
470	Ubiquitination	VRSGANVLICGPNGC EECCCEEEEECCCCC	2.41	21963094
472	S-nitrosylation	SGANVLICGPNGCGK CCCEEEEECCCCCCH	6.92	2212679
479	Ubiquitination	CGPNGCGKSSLFRVL ECCCCCCHHHHHHHH	40.73	21963094
481	Phosphorylation	PNGCGKSSLFRVLGE CCCCCHHHHHHHHHH	34.71	24719451
499	Ubiquitination	LFGGRLTKPERGKLF HHCCCCCCCCCCCCE	49.85	23000965
503	Ubiquitination	RLTKPERGKLFYVPQ CCCCCCCCCCEEECC	29.38	21963094
504	Ubiquitination	LTKPERGKLFYVPQR CCCCCCCCCEEECCC	41.46	23000965
523	Ubiquitination	LGTLRDQVIYPDGRE CCCCCCEEECCCCCH	5.47	23000965
525	Phosphorylation	TLRDQVIYPDGREDQ CCCCEEECCCCCHHH	9.09	20068231
528	Ubiquitination	DQVIYPDGREDQKRK CEEECCCCCHHHHHC	30.30	23000965
533	Acetylation	PDGREDQKRKGISDL CCCCHHHHHCCHHHH	69.29	25953088
533	Ubiquitination	PDGREDQKRKGISDL CCCCHHHHHCCHHHH	69.29	22817900
535	Ubiquitination	GREDQKRKGISDLVL CCHHHHHCCHHHHHH	68.57	21906983
535 (in isoform 1)	Ubiquitination	-	68.57	21890473
543	Ubiquitination	GISDLVLKEYLDNVQ CHHHHHHHHHHHCCC	36.51	21906983
543 (in isoform 1)	Ubiquitination	-	36.51	21890473
545	Phosphorylation	SDLVLKEYLDNVQLG HHHHHHHHHHCCCHH	20.12	110743155
557	Ubiquitination	QLGHILEREGGWDSV CHHHHHHCCCCCHHH	44.40	22817900
559	Ubiquitination	GHILEREGGWDSVQD HHHHHCCCCCHHHHH	49.03	22817900
567	Ubiquitination	GWDSVQDWMDVLSGG CCHHHHHHHHHHCCH	2.81	21963094
572	Phosphorylation	QDWMDVLSGGEKQRM HHHHHHHCCHHHHHH	44.60	110743163
576	Acetylation	DVLSGGEKQRMAMAR HHHCCHHHHHHHHHH	46.62	26051181
576	Ubiquitination	DVLSGGEKQRMAMAR HHHCCHHHHHHHHHH	46.62	21963094
576 (in isoform 1)	Ubiquitination	-	46.62	21890473
600	Ubiquitination	ILDECTSAVSVDVEG EHHCCCCCEEEECCH	4.58	21963094
619	Phosphorylation	HCRKVGITLFTVSHR HHCCEEEEEEEECCC	15.19	30108239
622	Phosphorylation	KVGITLFTVSHRKSL CEEEEEEEECCCHHH	24.98	30108239
624	Phosphorylation	GITLFTVSHRKSLWK EEEEEEECCCHHHHH	17.95	30108239
631	Acetylation	SHRKSLWKHHEYYLH CCCHHHHHCCEEEEC	40.14	25825284
635	Phosphorylation	SLWKHHEYYLHMDGR HHHHCCEEEECCCCC	13.63	7601317
636	Phosphorylation	LWKHHEYYLHMDGRG HHHCCEEEECCCCCC	6.27	7601329
645	Phosphorylation	HMDGRGNYEFKQITE CCCCCCCEEEEECCC	26.10	7601341
651	Phosphorylation	NYEFKQITEDTVEFG CEEEEECCCCCCCCC	25.89	29759185
654	Phosphorylation	FKQITEDTVEFGS-- EEECCCCCCCCCC--	18.72	113307785
659	Phosphorylation	EDTVEFGS------- CCCCCCCC-------	42.23	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABCD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABCD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABCD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABCD1_HUMAN	ABCD1	physical	10551832
PEX19_HUMAN	PEX19	physical	11453642
PEX3_HUMAN	PEX3	physical	22939629
NDUV1_HUMAN	NDUFV1	physical	22939629
MPV17_HUMAN	MPV17	physical	22939629
TAP1_HUMAN	TAP1	physical	22939629
VATC1_HUMAN	ATP6V1C1	physical	22939629
ADAS_HUMAN	AGPS	physical	22939629
NNTM_HUMAN	NNT	physical	22939629
SURF1_HUMAN	SURF1	physical	22939629
SYJ2B_HUMAN	SYNJ2BP	physical	22939629
RM41_HUMAN	MRPL41	physical	22939629
ZN454_HUMAN	ZNF454	physical	22939629
TIDC1_HUMAN	TIMMDC1	physical	22939629
NDUBB_HUMAN	NDUFB11	physical	22939629
NDUS4_HUMAN	NDUFS4	physical	22939629
TOM40_HUMAN	TOMM40	physical	22939629
TUFT1_HUMAN	TUFT1	physical	21988832
PSA1_HUMAN	PSMA1	physical	21988832
EF2_HUMAN	EEF2	physical	26344197
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616278: Congenital bile acid synthesis defect 5 (CBAS5)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-260 AND LYS-399, AND MASSSPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-145, AND MASSSPECTROMETRY.
PubMed: 18187866