| UniProt ID | TUFT1_HUMAN | |
|---|---|---|
| UniProt AC | Q9NNX1 | |
| Protein Name | Tuftelin | |
| Gene Name | TUFT1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 390 | |
| Subcellular Localization | Secreted . Secreted at a very early stage of enamel formation, concentrated at the dentin-enamel junction and tightly bound to the surface of the growing crystallites. | |
| Protein Description | Involved in the mineralization and structural organization of enamel.. | |
| Protein Sequence | MNGTRNWCTLVDVHPEDQAAGSVDILRLTLQGELTGDELEHIAQKAGRKTYAMVSSHSAGHSLASELVESHDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCLQKLREDISSKLDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINEDVESLRKTVQDLLAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEVGELQRRLLGMETEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIHHLDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIEKQISHGNFSTQARAKTENPGSIRISKPPSPKPMPVIRVVET | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 (in isoform 2) | Phosphorylation | - | 18.80 | 22210691 | |
| 9 (in isoform 2) | Phosphorylation | - | 22.79 | 22210691 | |
| 50 | Phosphorylation | AQKAGRKTYAMVSSH HHHCCCCCEEEECCC | 18.36 | - | |
| 55 | Phosphorylation | RKTYAMVSSHSAGHS CCCEEEECCCHHCCH | 14.84 | 28348404 | |
| 56 | Phosphorylation | KTYAMVSSHSAGHSL CCEEEECCCHHCCHH | 15.28 | 27251275 | |
| 58 | Phosphorylation | YAMVSSHSAGHSLAS EEEECCCHHCCHHHH | 37.58 | 28348404 | |
| 62 | Phosphorylation | SSHSAGHSLASELVE CCCHHCCHHHHHHHH | 25.39 | - | |
| 94 | Ubiquitination | GDKMIHEKNINQLKS CCCCHHHHCHHHHHH | 49.30 | - | |
| 100 | Ubiquitination | EKNINQLKSEVQYIQ HHCHHHHHHHHHHHH | 34.50 | - | |
| 115 | Ubiquitination | EARNCLQKLREDISS HHHHHHHHHHHHHHH | 36.24 | - | |
| 123 | Ubiquitination | LREDISSKLDRNLGD HHHHHHHHHHHHHHH | 47.84 | - | |
| 131 | Phosphorylation | LDRNLGDSLHRQEIQ HHHHHHHHHHHHHHE | 25.03 | 20873877 | |
| 148 | Phosphorylation | LEKPNGFSQSPTALY EECCCCCCCCCCCCC | 31.02 | 28348404 | |
| 150 | Phosphorylation | KPNGFSQSPTALYSS CCCCCCCCCCCCCCC | 24.03 | 27251275 | |
| 152 | Phosphorylation | NGFSQSPTALYSSPP CCCCCCCCCCCCCCC | 34.24 | 28348404 | |
| 157 | Phosphorylation | SPTALYSSPPEVDTC CCCCCCCCCCCCCHH | 30.80 | - | |
| 171 | Phosphorylation | CINEDVESLRKTVQD HCCCCHHHHHHHHHH | 33.07 | 24719451 | |
| 182 | Ubiquitination | TVQDLLAKLQEAKRQ HHHHHHHHHHHHHHH | 51.15 | - | |
| 192 | Phosphorylation | EAKRQHQSDCVAFEV HHHHHCHHCCEEEEH | 30.74 | 25002506 | |
| 200 | Phosphorylation | DCVAFEVTLSRYQRE CCEEEEHHHHHHHHH | 16.30 | 25002506 | |
| 225 | Ubiquitination | EEDRVEQKEAEVGEL HHHHHHHHHHHHHHH | 45.44 | - | |
| 276 | Phosphorylation | AEREKAATLEKEVAG HHHHHHHHHHHHHHH | 40.07 | 24719451 | |
| 279 | 2-Hydroxyisobutyrylation | EKAATLEKEVAGLRE HHHHHHHHHHHHHHH | 61.68 | - | |
| 312 | Phosphorylation | MIEQLQNSKAVIQSK HHHHHHCCCHHHCCC | 14.72 | 24043423 | |
| 319 | Ubiquitination | SKAVIQSKDATIQEL CCHHHCCCCHHHHHH | 34.70 | - | |
| 370 | Phosphorylation | AKTENPGSIRISKPP CCCCCCCCCEECCCC | 15.22 | 24719451 | |
| 374 | Phosphorylation | NPGSIRISKPPSPKP CCCCCEECCCCCCCC | 29.30 | 30619164 | |
| 378 | Phosphorylation | IRISKPPSPKPMPVI CEECCCCCCCCCCEE | 54.83 | 25159151 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TUFT1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TUFT1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TUFT1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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