dbPTM

CCD93_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CCD93_HUMAN
UniProt AC	Q567U6
Protein Name	Coiled-coil domain-containing protein 93
Gene Name	CCDC93
Organism	Homo sapiens (Human).
Sequence Length	631
Subcellular Localization	Early endosome .
Protein Description	Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C. [PubMed: 25355947]
Protein Sequence	MGLPRGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWCITTCNFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVVQWLVKRAIETKEEMGDYIRSYSVSQFQKTYSLPEDDDFIKRKEKAIKTVVDLSEVYKPRRKYKRHQGAEELLDEESRIHATLLEYGRRYGFSRQSKMEKAEDKKTALPAGLSATEKADAHEEDELRAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSAEIKQIVSEYAEKQSELSAEESPEKLGTSQLHRRKVISLNKQIAQKTKHLEELRASHTSLQARYNEAKKTLTELKTYSEKLDKEQAALEKIESKADPSILQNLRALVAMNENLKSQEQEFKAHCREEMTRLQQEIENLKAERAPRGDEKTLSSGEPPGTLTSAMTHDEDLDRRYNMEKEKLYKIRLLQARRNREIAILHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKEISLLNSIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLEKQRLYFKTVKEFKEEGRKNEMLLSKVKAKAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Ubiquitination	EGQGLPEVETREDEE CCCCCCCCCCCCCHH	9.57	22817900
27	Ubiquitination	DEEQNVKLTEILELL CHHHCCHHHHHHHHH	4.53	22817900
29	Ubiquitination	EQNVKLTEILELLVA HHCCHHHHHHHHHHH	56.89	22817900
31	Ubiquitination	NVKLTEILELLVAAG CCHHHHHHHHHHHCC	2.86	22817900
35	Ubiquitination	TEILELLVAAGYFRA HHHHHHHHHCCHHHH	5.54	24816145
45	Ubiquitination	GYFRARIKGLSPFDK CHHHHHHCCCCHHHH	48.52	-
52	Ubiquitination	KGLSPFDKVVGGMTW CCCCHHHHHHCCEEE	38.92	22817900
64	Ubiquitination	MTWCITTCNFDVDVD EEEEEHHCCCCCCHH	3.41	22817900
66	Ubiquitination	WCITTCNFDVDVDLL EEEHHCCCCCCHHHH	12.01	22817900
68	Ubiquitination	ITTCNFDVDVDLLFQ EHHCCCCCCHHHHEE	7.27	22817900
89	Ubiquitination	QKIALSEKIVSVLPR HHHHCCHHHHHHCCC	45.06	-
92	Phosphorylation	ALSEKIVSVLPRMKC HCCHHHHHHCCCCCC	22.78	32142685
131	Ubiquitination	VKRAIETKEEMGDYI HHHHHHCHHHHHHHH	38.60	24816145
137	Phosphorylation	TKEEMGDYIRSYSVS CHHHHHHHHHHCCHH	7.78	24670416
142	Phosphorylation	GDYIRSYSVSQFQKT HHHHHHCCHHHHHHH	19.28	28857561
148	Ubiquitination	YSVSQFQKTYSLPED CCHHHHHHHCCCCCC	51.20	21906983
149	Phosphorylation	SVSQFQKTYSLPEDD CHHHHHHHCCCCCCC	13.94	30624053
150	Phosphorylation	VSQFQKTYSLPEDDD HHHHHHHCCCCCCCH	18.42	27642862
151	Phosphorylation	SQFQKTYSLPEDDDF HHHHHHCCCCCCCHH	42.55	29507054
160	Ubiquitination	PEDDDFIKRKEKAIK CCCCHHHHHHHHHHH	58.36	21906983
162	Ubiquitination	DDDFIKRKEKAIKTV CCHHHHHHHHHHHHH	59.57	22817900
164	Ubiquitination	DFIKRKEKAIKTVVD HHHHHHHHHHHHHHC	59.45	22817900
173	Phosphorylation	IKTVVDLSEVYKPRR HHHHHCHHHHHCCCH	22.13	24719451
176	Phosphorylation	VVDLSEVYKPRRKYK HHCHHHHHCCCHHHH	15.95	24719451
177	Ubiquitination	VDLSEVYKPRRKYKR HCHHHHHCCCHHHHC	36.90	29967540
187	Ubiquitination	RKYKRHQGAEELLDE HHHHCCCCHHHHCCH	28.91	24816145
204	Ubiquitination	RIHATLLEYGRRYGF HHHHHHHHHHHHHCC	49.40	22817900
209	Phosphorylation	LLEYGRRYGFSRQSK HHHHHHHHCCCCHHH	22.59	-
216	Ubiquitination	YGFSRQSKMEKAEDK HCCCCHHHHCHHCCH	42.62	22817900
218	Ubiquitination	FSRQSKMEKAEDKKT CCCHHHHCHHCCHHC	53.50	22817900
220	Ubiquitination	RQSKMEKAEDKKTAL CHHHHCHHCCHHCCC	19.53	22817900
224	Ubiquitination	MEKAEDKKTALPAGL HCHHCCHHCCCCCCC	51.88	29967540
236	Ubiquitination	AGLSATEKADAHEED CCCCHHHCCCCCCHH	47.41	32015554
240	Ubiquitination	ATEKADAHEEDELRA HHHCCCCCCHHHHHH	39.25	22817900
244	Ubiquitination	ADAHEEDELRAAEEQ CCCCCHHHHHHHHHH	43.36	22817900
255	Phosphorylation	AEEQRIQSLMTKMTA HHHHHHHHHHHHHHH	20.10	28857561
259	Ubiquitination	RIQSLMTKMTAMANE HHHHHHHHHHHHCCH	21.93	29967540
261	Phosphorylation	QSLMTKMTAMANEES HHHHHHHHHHCCHHH	18.16	-
264	Ubiquitination	MTKMTAMANEESRLT HHHHHHHCCHHHHCC	20.16	22817900
268	Phosphorylation	TAMANEESRLTASSV HHHCCHHHHCCHHHH	26.81	-
271	Phosphorylation	ANEESRLTASSVGQI CCHHHHCCHHHHHHH	24.31	25072903
273	Phosphorylation	EESRLTASSVGQIVG HHHHCCHHHHHHHHH	21.96	26657352
274	Phosphorylation	ESRLTASSVGQIVGL HHHCCHHHHHHHHHH	28.01	28857561
277	Ubiquitination	LTASSVGQIVGLCSA CCHHHHHHHHHHCHH	25.66	22817900
281	Ubiquitination	SVGQIVGLCSAEIKQ HHHHHHHHCHHHHHH	1.12	22817900
287	Ubiquitination	GLCSAEIKQIVSEYA HHCHHHHHHHHHHHH	26.02	-
289	Ubiquitination	CSAEIKQIVSEYAEK CHHHHHHHHHHHHHH	2.90	24816145
296	Ubiquitination	IVSEYAEKQSELSAE HHHHHHHHHHHCCCC	51.45	29967540
298	Phosphorylation	SEYAEKQSELSAEES HHHHHHHHHCCCCCC	52.12	23927012
301	Phosphorylation	AEKQSELSAEESPEK HHHHHHCCCCCCHHH	29.59	29255136
301	Ubiquitination	AEKQSELSAEESPEK HHHHHHCCCCCCHHH	29.59	22817900
305	Phosphorylation	SELSAEESPEKLGTS HHCCCCCCHHHHCCC	29.84	29255136
308	Ubiquitination	SAEESPEKLGTSQLH CCCCCHHHHCCCHHH	56.45	29967540
311	Phosphorylation	ESPEKLGTSQLHRRK CCHHHHCCCHHHHHH	24.60	23403867
312	Phosphorylation	SPEKLGTSQLHRRKV CHHHHCCCHHHHHHH	29.01	23403867
318	Ubiquitination	TSQLHRRKVISLNKQ CCHHHHHHHHHHHHH	43.83	29967540
321	Phosphorylation	LHRRKVISLNKQIAQ HHHHHHHHHHHHHHH	28.95	21712546
324	Ubiquitination	RKVISLNKQIAQKTK HHHHHHHHHHHHHHH	48.66	29967540
324	Malonylation	RKVISLNKQIAQKTK HHHHHHHHHHHHHHH	48.66	26320211
326	Ubiquitination	VISLNKQIAQKTKHL HHHHHHHHHHHHHCH	4.72	24816145
347	Phosphorylation	HTSLQARYNEAKKTL HHHHHHHHHHHHHHH	21.99	22817900
351	Ubiquitination	QARYNEAKKTLTELK HHHHHHHHHHHHHHH	39.86	24816145
351	Acetylation	QARYNEAKKTLTELK HHHHHHHHHHHHHHH	39.86	20167786
352	Acetylation	ARYNEAKKTLTELKT HHHHHHHHHHHHHHH	56.68	20167786
353	Phosphorylation	RYNEAKKTLTELKTY HHHHHHHHHHHHHHH	37.90	25072903
355	Phosphorylation	NEAKKTLTELKTYSE HHHHHHHHHHHHHHH	44.49	25072903
358	Acetylation	KKTLTELKTYSEKLD HHHHHHHHHHHHHCC	38.90	7822347
359	Phosphorylation	KTLTELKTYSEKLDK HHHHHHHHHHHHCCH	44.92	25072903
360	Phosphorylation	TLTELKTYSEKLDKE HHHHHHHHHHHCCHH	17.16	25072903
361	Phosphorylation	LTELKTYSEKLDKEQ HHHHHHHHHHCCHHH	33.22	25072903
363	Ubiquitination	ELKTYSEKLDKEQAA HHHHHHHHCCHHHHH	56.92	-
366	Ubiquitination	TYSEKLDKEQAALEK HHHHHCCHHHHHHHH	63.26	24816145
373	Ubiquitination	KEQAALEKIESKADP HHHHHHHHHHHHCCH	53.26	22817900
377	Malonylation	ALEKIESKADPSILQ HHHHHHHHCCHHHHH	43.98	26320211
377	Ubiquitination	ALEKIESKADPSILQ HHHHHHHHCCHHHHH	43.98	22817900
388	Ubiquitination	SILQNLRALVAMNEN HHHHHHHHHHHHCHH	15.00	24816145
397	Ubiquitination	VAMNENLKSQEQEFK HHHCHHHHHHHHHHH	62.77	22817900
403	Ubiquitination	LKSQEQEFKAHCREE HHHHHHHHHHHHHHH	9.41	24816145
404	Ubiquitination	KSQEQEFKAHCREEM HHHHHHHHHHHHHHH	36.15	29967540
422	Ubiquitination	QQEIENLKAERAPRG HHHHHHHHHHCCCCC	60.84	24816145
428	Ubiquitination	LKAERAPRGDEKTLS HHHHCCCCCCCCCCC	65.30	22817900
432	Ubiquitination	RAPRGDEKTLSSGEP CCCCCCCCCCCCCCC	60.55	22817900
433	Phosphorylation	APRGDEKTLSSGEPP CCCCCCCCCCCCCCC	29.80	-
452	Ubiquitination	SAMTHDEDLDRRYNM CCCCCCHHHHHHHCC	60.98	22817900
457	Phosphorylation	DEDLDRRYNMEKEKL CHHHHHHHCCCHHHH	21.54	29083192
477	Ubiquitination	LQARRNREIAILHRK HHHHCCCHHHEEECC	40.08	24816145
484	Ubiquitination	EIAILHRKIDEVPSR HHHEEECCHHHCCCH	43.70	24816145
499	Ubiquitination	AELIQYQKRFIELYR HHHHHHHHHHHHHHH	44.32	24816145
509	Phosphorylation	IELYRQISAVHKETK HHHHHHHHHHHHHHH	18.85	28509920
539	Ubiquitination	LEKEISLLNSIHENF HHHHHHHHHHHHHHH	3.64	24816145
552	Phosphorylation	NFSQAMASPAARDQF HHHHHHCCHHHHHHH	11.29	26329039
554	Ubiquitination	SQAMASPAARDQFLR HHHHCCHHHHHHHHH	16.78	24816145
571	Ubiquitination	EQIVEGIKQSRMKME HHHHHHHHHHHHHHH	53.75	-
573	Phosphorylation	IVEGIKQSRMKMEKK HHHHHHHHHHHHHHH	29.37	-
601	Ubiquitination	QYLELLEKQRLYFKT HHHHHHHHHCHHHHH	40.46	29967540
625	Ubiquitination	KNEMLLSKVKAKAS- CCHHHHHHHHHHCC-	47.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CCD93_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CCD93_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CCD93_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C40_HUMAN	KRT40	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
CCD22_HUMAN	CCDC22	physical	25355947
CP062_HUMAN	C16orf62	physical	25355947
COMD1_HUMAN	COMMD1	physical	25355947
COMD6_HUMAN	COMMD6	physical	25355947
CCD22_HUMAN	CCDC22	physical	26344197
COMDA_HUMAN	COMMD10	physical	26344197
COMD2_HUMAN	COMMD2	physical	26344197
MNS1_HUMAN	MNS1	physical	26344197
GOGB1_HUMAN	GOLGB1	physical	26496610
HNRPC_HUMAN	HNRNPC	physical	26496610
PDK1_HUMAN	PDK1	physical	26496610
PRS6A_HUMAN	PSMC3	physical	26496610
FXR1_HUMAN	FXR1	physical	26496610
DSCR3_HUMAN	DSCR3	physical	26496610
COMD3_HUMAN	COMMD3	physical	26496610
LTN1_HUMAN	LTN1	physical	26496610
CCD22_HUMAN	CCDC22	physical	26496610
COMD5_HUMAN	COMMD5	physical	26496610
COMD9_HUMAN	COMMD9	physical	26496610
COMD2_HUMAN	COMMD2	physical	26496610
COMDA_HUMAN	COMMD10	physical	26496610
VPS29_HUMAN	VPS29	physical	26496610
COMD8_HUMAN	COMMD8	physical	26496610
TM248_HUMAN	TMEM248	physical	26496610
CP062_HUMAN	C16orf62	physical	26496610
CPSF7_HUMAN	CPSF7	physical	26496610
ZIC4_HUMAN	ZIC4	physical	26496610
COMD7_HUMAN	COMMD7	physical	26496610
COMD1_HUMAN	COMMD1	physical	26496610
DHX36_HUMAN	DHX36	physical	26496610
COMD6_HUMAN	COMMD6	physical	26496610
FA45A_HUMAN	FAM45A	physical	26496610
PKN3_HUMAN	PKN3	physical	27173435
NCK5L_HUMAN	NCKAP5L	physical	27173435
TFPT_HUMAN	TFPT	physical	27173435
YETS4_HUMAN	YEATS4	physical	27173435
GOGA5_HUMAN	GOLGA5	physical	27173435
CLOCK_HUMAN	CLOCK	physical	27173435
PSMD9_HUMAN	PSMD9	physical	27173435
DZIP3_HUMAN	DZIP3	physical	27173435
GRAP1_HUMAN	GRIPAP1	physical	27173435
VPS50_HUMAN	CCDC132	physical	27173435
PF21A_HUMAN	PHF21A	physical	27173435
CAVN1_HUMAN	PTRF	physical	27173435
HAUS6_HUMAN	HAUS6	physical	27173435
RPR1A_HUMAN	RPRD1A	physical	27173435
BMAL1_HUMAN	ARNTL	physical	27173435
RABX5_HUMAN	RABGEF1	physical	27173435
NUF2_HUMAN	NUF2	physical	27173435
EIPR1_HUMAN	TSSC1	physical	27173435
JUN_HUMAN	JUN	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CCD93_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; SER-301 ANDSER-305, AND MASS SPECTROMETRY.	18691976 [Abstract]