COMD6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COMD6_HUMAN
• UniProt AC: Q7Z4G1
• Protein Name: COMM domain-containing protein 6
• Gene Name: COMMD6
• Organism: Homo sapiens (Human).
• Sequence Length: 85
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. [PubMed: 21778237 Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.]
• Protein Sequence: MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKEIAAVIETV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEASSEPP -------CCCCCCCC	9.78	19413330
12	Ubiquitination	SEPPLDAKSDVTNQL CCCCCCCCCHHHHHH	47.02	23000965
28	Sulfoxidation	DFQWKLGMAVSSDTC HHHHHHCCCCCCHHH	4.89	21406390
31	Phosphorylation	WKLGMAVSSDTCRSL HHHCCCCCCHHHHHC	16.98	27251275
32 (in isoform 2)	Phosphorylation	-	30.27	27251275
32	Phosphorylation	KLGMAVSSDTCRSLK HHCCCCCCHHHHHCC	30.27	27251275
39	Acetylation	SDTCRSLKYPYVAVM CHHHHHCCCCEEEEE	45.48	20167786
39	Ubiquitination	SDTCRSLKYPYVAVM CHHHHHCCCCEEEEE	45.48	23000965
39 (in isoform 2)	Ubiquitination	-	45.48	21890473
39 (in isoform 1)	Ubiquitination	-	45.48	21890473
48	Acetylation	PYVAVMLKVADHSGQ CEEEEEEEECCCCCC	19.79	20167786
57	Acetylation	ADHSGQVKTKCFEMT CCCCCCEEEEEEEEE	34.09	25953088
72	Phosphorylation	IPQFQNFYRQFKEIA HHHHHHHHHHHHHHH	15.85	30257219
79	Ubiquitination	YRQFKEIAAVIETV- HHHHHHHHHHEECC-	9.21	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COMD6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COMD6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COMD6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COMD1_HUMAN	COMMD1	physical	15799966
TF65_HUMAN	RELA	physical	15799966
NFKB1_HUMAN	NFKB1	physical	15799966
COMD1_HUMAN	COMMD1	physical	16573520
COMD6_HUMAN	COMMD6	physical	16573520
TF65_HUMAN	RELA	physical	16573520
CCD22_HUMAN	CCDC22	physical	23563313
COMD1_HUMAN	COMMD1	physical	23563313
COMDA_HUMAN	COMMD10	physical	23563313
COMD1_HUMAN	COMMD1	physical	28514442
COMDA_HUMAN	COMMD10	physical	28514442
FA45A_HUMAN	FAM45A	physical	28514442
COMD2_HUMAN	COMMD2	physical	28514442
COMD4_HUMAN	COMMD4	physical	28514442
COMD8_HUMAN	COMMD8	physical	28514442
CCD22_HUMAN	CCDC22	physical	28514442
COMD3_HUMAN	COMMD3	physical	28514442
CCD93_HUMAN	CCDC93	physical	28514442
CP062_HUMAN	C16orf62	physical	28514442
COMD5_HUMAN	COMMD5	physical	28514442
COMD9_HUMAN	COMMD9	physical	28514442
DSCR3_HUMAN	DSCR3	physical	28514442
COMD7_HUMAN	COMMD7	physical	28514442
E2F6_HUMAN	E2F6	physical	28514442
VPS29_HUMAN	VPS29	physical	28514442
TFDP1_HUMAN	TFDP1	physical	28514442
VP33B_HUMAN	VPS33B	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442
EMB_HUMAN	EMB	physical	28514442
TM2D3_HUMAN	TM2D3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330