COMD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COMD2_HUMAN
• UniProt AC: Q86X83
• Protein Name: COMM domain-containing protein 2
• Gene Name: COMMD2
• Organism: Homo sapiens (Human).
• Sequence Length: 199
• Subcellular Localization: Cytoplasm .
• Protein Description: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. [PubMed: 21778237 May down-regulate activation of NF-kappa-B]
• Protein Sequence: MLLELSEEHKEHLAFLPQVDSAVVAEFGRIAVEFLRRGANPKIYEGAARKLNVSSDTVQHGVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLDNRKEIRTILSELAPSLPSYHNLEWRLDVQLASRSLRQQIKPAVTIKLHLNQNGDHNTKVLQTDPATLLHLVQQLEQALEEMKTNHCRRVVRNIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Methylation	RIAVEFLRRGANPKI HHHHHHHHCCCCCHH	40.06	-
42	Ubiquitination	LRRGANPKIYEGAAR HHCCCCCHHHHHHHH	58.70	33845483
42	Malonylation	LRRGANPKIYEGAAR HHCCCCCHHHHHHHH	58.70	26320211
50	Ubiquitination	IYEGAARKLNVSSDT HHHHHHHHCCCCCHH	39.42	29967540
73	Phosphorylation	TYLLTESSKLMISEL HHHHHCCCCEEEEEC	24.47	-
145	Ubiquitination	RSLRQQIKPAVTIKL HHHHHHCCCCEEEEE	23.68	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COMD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COMD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COMD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COMD1_HUMAN	COMMD1	physical	15799966
TF65_HUMAN	RELA	physical	15799966
RELB_HUMAN	RELB	physical	15799966
NFKB1_HUMAN	NFKB1	physical	15799966
NFKB2_HUMAN	NFKB2	physical	15799966
A4_HUMAN	APP	physical	21832049
RHG17_HUMAN	ARHGAP17	physical	26344197
COMD1_HUMAN	COMMD1	physical	26344197
COMD4_HUMAN	COMMD4	physical	26344197
COMD5_HUMAN	COMMD5	physical	26344197
COMD8_HUMAN	COMMD8	physical	26344197
MCMBP_HUMAN	MCMBP	physical	26344197
TIPRL_HUMAN	TIPRL	physical	26344197
CCD22_HUMAN	CCDC22	physical	28514442
COMD3_HUMAN	COMMD3	physical	28514442
COMD4_HUMAN	COMMD4	physical	28514442
FA45A_HUMAN	FAM45A	physical	28514442
COMD5_HUMAN	COMMD5	physical	28514442
CCD93_HUMAN	CCDC93	physical	28514442
CP062_HUMAN	C16orf62	physical	28514442
COMD7_HUMAN	COMMD7	physical	28514442
COMD9_HUMAN	COMMD9	physical	28514442
VPS29_HUMAN	VPS29	physical	28514442
FAT3_HUMAN	FAT3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.