COMD7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COMD7_HUMAN
• UniProt AC: Q86VX2
• Protein Name: COMM domain-containing protein 7
• Gene Name: COMMD7
• Organism: Homo sapiens (Human).
• Sequence Length: 200
• Subcellular Localization: Cytoplasmic vesicle .
• Protein Description: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. [PubMed: 21778237 Associates with the NF-kappa-B complex and suppresses its transcriptional activity]
• Protein Sequence: MGRLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSMECFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	ERFLAQLSEFATTNQ HHHHHHHHHHHCCCC	20.70	-
67	Phosphorylation	TNQISLGSLRSIVKS CCCCCHHHHHHHHHH	26.38	24719451
72	Ubiquitination	LGSLRSIVKSLLLVP HHHHHHHHHHHCCCC	3.48	21890473
72 (in isoform 2)	Ubiquitination	-	3.48	21890473
73	Ubiquitination	GSLRSIVKSLLLVPN HHHHHHHHHHCCCCC	33.44	22817900
73 (in isoform 1)	Ubiquitination	-	33.44	21890473
89	Ubiquitination	ALKKSLTAKQVQADF HHCCCCCHHHHHHCE	12.94	29967540
90	Ubiquitination	LKKSLTAKQVQADFI HCCCCCHHHHHHCEE	45.85	29967540
104	Ubiquitination	ITLGLSEEKATYFSE EEECCCHHHHHHHCH	44.61	29967540
105	Ubiquitination	TLGLSEEKATYFSEK EECCCHHHHHHHCHH	41.81	29967540
144	Phosphorylation	MEWKFGVTSGSSELE CEECCCCCCCCHHHH	27.96	26699800
145	Phosphorylation	EWKFGVTSGSSELEK EECCCCCCCCHHHHH	33.98	26699800
147	Phosphorylation	KFGVTSGSSELEKVG CCCCCCCCHHHHHHH	22.02	26699800
148	Phosphorylation	FGVTSGSSELEKVGS CCCCCCCHHHHHHHH	50.13	26699800

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COMD7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COMD7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COMD7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COMD1_HUMAN	COMMD1	physical	15799966
TF65_HUMAN	RELA	physical	15799966
COMD8_HUMAN	COMMD8	physical	22939629
COMDA_HUMAN	COMMD10	physical	22939629
COMD9_HUMAN	COMMD9	physical	22939629
COMD1_HUMAN	COMMD1	physical	26344197
COMD1_HUMAN	COMMD1	physical	26060140
COMD6_HUMAN	COMMD6	physical	26060140
IKKA_HUMAN	CHUK	physical	26060140
IKKB_HUMAN	IKBKB	physical	26060140

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.