COMD9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COMD9_HUMAN
• UniProt AC: Q9P000
• Protein Name: COMM domain-containing protein 9
• Gene Name: COMMD9
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Subcellular Localization: Nucleus . Cytoplasmic vesicle .
• Protein Description: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. [PubMed: 21778237 May down-regulate activation of NF-kappa-B]
• Protein Sequence: MAALTAEHFAALQSLLKASSKDVVRQLCQESFSSSALGLKKLLDVTCSSLSVTQEEAEELLQALHRLTRLVAFRDLSSAEAILALFPENFHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAVTVELSKETLDTMLDGLGRIRDQLSAVASK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAALTAEHF ------CCCHHHHHH	15.92	25944712
14	Phosphorylation	EHFAALQSLLKASSK HHHHHHHHHHHHCCH	36.20	24719451
17	Ubiquitination	AALQSLLKASSKDVV HHHHHHHHHCCHHHH	52.06	-
19	Phosphorylation	LQSLLKASSKDVVRQ HHHHHHHCCHHHHHH	36.01	20068231
20	Phosphorylation	QSLLKASSKDVVRQL HHHHHHCCHHHHHHH	37.42	25278378
28	S-nitrosylation	KDVVRQLCQESFSSS HHHHHHHHHHCCCHH	2.97	24105792
31	Phosphorylation	VRQLCQESFSSSALG HHHHHHHCCCHHHCC	12.44	29507054
40	Ubiquitination	SSSALGLKKLLDVTC CHHHCCHHHHHHCHH	39.31	-
41	Ubiquitination	SSALGLKKLLDVTCS HHHCCHHHHHHCHHH	60.36	-
47	S-nitrosylation	KKLLDVTCSSLSVTQ HHHHHCHHHCCCCCH	2.33	24105792
100	Ubiquitination	NLKNLLTKIILEHVS HHHHHHHHHHHHHHH	27.93	-
108	Phosphorylation	IILEHVSTWRTEAQA HHHHHHHHHCCHHHH	20.20	24719451
111	Phosphorylation	EHVSTWRTEAQANQI HHHHHHCCHHHHHCC	27.51	22210691
119	Phosphorylation	EAQANQISLPRLVDL HHHHHCCCCCCCCCC	23.66	24719451
133	Ubiquitination	LDWRVDIKTSSDSIS CCEEEEEECCCHHHH	37.58	-
147	S-nitrosylation	SRMAVPTCLLQMKIQ HHHHHCHHHHHHHHC	2.67	24105792
163	Ubiquitination	DPSLCGDKPSISAVT CHHHCCCCCCCEEEE	26.42	-
193	Phosphorylation	GRIRDQLSAVASK-- HHHHHHHHHHHCC--	18.31	23403867
197	Phosphorylation	DQLSAVASK------ HHHHHHHCC------	32.09	23403867
198	Ubiquitination	QLSAVASK------- HHHHHHCC-------	55.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COMD9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COMD9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COMD9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RELB_HUMAN	RELB	physical	15799966
NFKB1_HUMAN	NFKB1	physical	15799966
CCD22_HUMAN	CCDC22	physical	23563313
COMD3_HUMAN	COMMD3	physical	26344197
COMD6_HUMAN	COMMD6	physical	26344197
XPO7_HUMAN	XPO7	physical	26344197

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.