COMDA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COMDA_HUMAN
• UniProt AC: Q9Y6G5
• Protein Name: COMM domain-containing protein 10
• Gene Name: COMMD10
• Organism: Homo sapiens (Human).
• Sequence Length: 202
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. [PubMed: 21778237 May down-regulate activation of NF-kappa-B]
• Protein Sequence: MAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSLEKVLVEFSHKELFDFYNKLETIQAQLDSLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVPAALIL ------CCCCHHHHH	18.92	25944712
12	Phosphorylation	AALILRESPSMKKAV HHHHHHCCCCHHHHH	18.81	28464451
14	Phosphorylation	LILRESPSMKKAVSL HHHHCCCCHHHHHHH	53.14	28634298
20	Phosphorylation	PSMKKAVSLINAIDT CCHHHHHHHHHHHHC	28.52	20068231
27	Phosphorylation	SLINAIDTGRFPRLL HHHHHHHCCCHHHHH	24.92	21406692
48	Phosphorylation	LHLKAESSFSEEEEE HHHHHHCCCCHHHHH	25.05	25159151
56	Ubiquitination	FSEEEEEKLQAAFSL CCHHHHHHHHHHHCC	49.53	-
105	Ubiquitination	NIHLRQDKAEAFVNT HCCCCHHHHHHHHHH	39.53	-
112	Phosphorylation	KAEAFVNTWSSMGQE HHHHHHHHHHHCCHH	22.79	29978859
114	Phosphorylation	EAFVNTWSSMGQETV HHHHHHHHHCCHHHH	14.38	29978859
115	Phosphorylation	AFVNTWSSMGQETVE HHHHHHHHCCHHHHH	20.63	29978859
123	Ubiquitination	MGQETVEKFRQRILA CCHHHHHHHHHHHHH	41.32	-
136	Phosphorylation	LAPCKLETVGWQLNL HHCCCCCCCCHHHHH	34.45	-
154	Ubiquitination	HSAQAKLKSPQAVLQ HHHHHHCCCCHHHHH	60.42	-
155	Phosphorylation	SAQAKLKSPQAVLQL HHHHHCCCCHHHHHH	32.45	30266825
169	Phosphorylation	LGVNNEDSKSLEKVL HCCCCCCCCCHHHHH	20.26	22199227
170	Ubiquitination	GVNNEDSKSLEKVLV CCCCCCCCCHHHHHH	71.96	-
174	Ubiquitination	EDSKSLEKVLVEFSH CCCCCHHHHHHHCCH	46.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COMDA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COMDA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COMDA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COMD1_HUMAN	COMMD1	physical	15799966
TF65_HUMAN	RELA	physical	15799966
RELB_HUMAN	RELB	physical	15799966
NFKB1_HUMAN	NFKB1	physical	15799966
CCD22_HUMAN	CCDC22	physical	23563313
CCD22_HUMAN	CCDC22	physical	26344197
COMD1_HUMAN	COMMD1	physical	26344197
COMD2_HUMAN	COMMD2	physical	26344197
COMD5_HUMAN	COMMD5	physical	26344197
COMD8_HUMAN	COMMD8	physical	28514442
COMD3_HUMAN	COMMD3	physical	28514442
COMD2_HUMAN	COMMD2	physical	28514442
FA45A_HUMAN	FAM45A	physical	28514442
COMD4_HUMAN	COMMD4	physical	28514442
CCD22_HUMAN	CCDC22	physical	28514442
COMD5_HUMAN	COMMD5	physical	28514442
VPS29_HUMAN	VPS29	physical	28514442
CP062_HUMAN	C16orf62	physical	28514442
COMD7_HUMAN	COMMD7	physical	28514442
TRI13_HUMAN	TRIM13	physical	28514442
COMD9_HUMAN	COMMD9	physical	28514442
FKB15_HUMAN	FKBP15	physical	28514442
CCD93_HUMAN	CCDC93	physical	28514442
TC1D2_HUMAN	TCTEX1D2	physical	28514442
DSCR3_HUMAN	DSCR3	physical	28514442
TRAF7_HUMAN	TRAF7	physical	28514442
HIKES_HUMAN	C11orf73	physical	28514442
PRPK_HUMAN	TP53RK	physical	28514442
TPRKB_HUMAN	TPRKB	physical	28514442
ACOT9_HUMAN	ACOT9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.