COMD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COMD5_HUMAN
• UniProt AC: Q9GZQ3
• Protein Name: COMM domain-containing protein 5
• Gene Name: COMMD5
• Organism: Homo sapiens (Human).
• Sequence Length: 224
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. [PubMed: 21778237 Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity Down-regulates activation of NF-kappa-B]
• Protein Sequence: MSAVGAATPYLHHPGDSHSGRVSFLGAQLPPEVAAMARLLGDLDRSTFRKLLKFVVSSLQGEDCREAVQRLGVSANLPEEQLGALLAGMHTLLQQALRLPPTSLKPDTFRDQLQELCIPQDLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEVPTAKFQELRYSVALVLKEMADLEKRCERRLQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAVGAATP ------CCCCCCCCC	31.49	25944712
2	Phosphorylation	------MSAVGAATP ------CCCCCCCCC	31.49	28857561
8	Phosphorylation	MSAVGAATPYLHHPG CCCCCCCCCCCCCCC	16.36	24043423
10	Phosphorylation	AVGAATPYLHHPGDS CCCCCCCCCCCCCCC	17.82	27642862
17	Phosphorylation	YLHHPGDSHSGRVSF CCCCCCCCCCCCEEE	26.01	24043423
19	Phosphorylation	HHPGDSHSGRVSFLG CCCCCCCCCCEEECC	32.04	24043423
140	Phosphorylation	SQRPLLDSVAQQQGA CCCHHHHHHHHHCCC	21.23	22210691
196	Ubiquitination	RFEVPTAKFQELRYS EEECCHHHHHHHHHH	50.48	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COMD5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COMD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COMD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COMD1_HUMAN	COMMD1	physical	15799966
TF65_HUMAN	RELA	physical	15799966
RELB_HUMAN	RELB	physical	15799966
NFKB1_HUMAN	NFKB1	physical	15799966
COMD1_HUMAN	COMMD1	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.