TPRKB_HUMAN - dbPTM
TPRKB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPRKB_HUMAN
UniProt AC Q9Y3C4
Protein Name EKC/KEOPS complex subunit TPRKB {ECO:0000305}
Gene Name TPRKB {ECO:0000312|HGNC:HGNC:24259}
Organism Homo sapiens (Human).
Sequence Length 175
Subcellular Localization Cytoplasm, cytosol . Nucleus .
Protein Description Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. [PubMed: 22912744]
Protein Sequence MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21 (in isoform 3)Ubiquitination-62.67-
21UbiquitinationRVTLLLFKDVKNAGD
HEEEEEECCCCCHHH		62.6733845483
24 (in isoform 3)Ubiquitination-51.73-
24UbiquitinationLLLFKDVKNAGDLRR
EEEECCCCCHHHHHH		51.7333845483
33UbiquitinationAGDLRRKAMEGTIDG
HHHHHHHHHCCCCCC		10.2329967540
48UbiquitinationSLINPTVIVDPFQIL
CCCCCEEEECHHHHH		2.9829967540
61 (in isoform 3)Phosphorylation-8.1829978859
61UbiquitinationILVAANKAVHLYKLG
HHHHHHHHHHHHHCC		8.1821963094
61 (in isoform 2)Ubiquitination-8.1821906983
62UbiquitinationLVAANKAVHLYKLGK
HHHHHHHHHHHHCCC		3.2322817900
64 (in isoform 3)Phosphorylation-3.0329978859
66 (in isoform 3)Phosphorylation-58.0629978859
66UbiquitinationNKAVHLYKLGKMKTR
HHHHHHHHCCCCCCC		58.0629967540
67 (in isoform 3)Phosphorylation-5.1429978859
69 (in isoform 3)Phosphorylation-47.8929978859
76PhosphorylationKMKTRTLSTEIIFNL
CCCCCCCEEEEEEEC		24.3119369195
76UbiquitinationKMKTRTLSTEIIFNL
CCCCCCCEEEEEEEC		24.3121963094
77UbiquitinationMKTRTLSTEIIFNLS
CCCCCCEEEEEEECC		34.0222817900
77PhosphorylationMKTRTLSTEIIFNLS
CCCCCCEEEEEEECC		34.02-
94UbiquitinationNNISEALKKFGISAN
CCHHHHHHHHCCCCC		53.7721906983
94 (in isoform 1)Ubiquitination-53.7721906983
95UbiquitinationNISEALKKFGISAND
CHHHHHHHHCCCCCC		50.0722817900
99PhosphorylationALKKFGISANDTSIL
HHHHHCCCCCCCEEE		22.7727762562
101 (in isoform 2)Ubiquitination-46.4321906983
101UbiquitinationKKFGISANDTSILIV
HHHCCCCCCCEEEEE		46.4321963094
105UbiquitinationISANDTSILIVYIEE
CCCCCCEEEEEEEEC		3.1029967540
105 (in isoform 3)Ubiquitination-3.10-
113 (in isoform 2)Ubiquitination-34.3121906983
113UbiquitinationLIVYIEEGEKQINQE
EEEEEECCCEEECHH		34.3122817900
114UbiquitinationIVYIEEGEKQINQEY
EEEEECCCEEECHHH		45.1022817900
116UbiquitinationYIEEGEKQINQEYLI
EEECCCEEECHHHHH		35.2521963094
117UbiquitinationIEEGEKQINQEYLIS
EECCCEEECHHHHHH		9.4722817900
121PhosphorylationEKQINQEYLISQVEG
CEEECHHHHHHEECC		10.2819060867
124PhosphorylationINQEYLISQVEGHQV
ECHHHHHHEECCCCC		26.1122798277
128UbiquitinationYLISQVEGHQVSLKN
HHHHEECCCCCCCCC		20.0522817900
129UbiquitinationLISQVEGHQVSLKNL
HHHEECCCCCCCCCC		16.0322817900
132PhosphorylationQVEGHQVSLKNLPEI
EECCCCCCCCCCHHH		27.3619060867
132UbiquitinationQVEGHQVSLKNLPEI
EECCCCCCCCCCHHH		27.3622817900
133 (in isoform 3)Ubiquitination-4.4721906983
133UbiquitinationVEGHQVSLKNLPEIM
ECCCCCCCCCCHHHH		4.4721963094
134UbiquitinationEGHQVSLKNLPEIMN
CCCCCCCCCCHHHHC		49.2721906983
134 (in isoform 1)Ubiquitination-49.2721906983
140SulfoxidationLKNLPEIMNITEVKK
CCCCHHHHCHHHHHH		2.5721406390
143PhosphorylationLPEIMNITEVKKIYK
CHHHHCHHHHHHHHH		29.7122798277
146 (in isoform 1)Ubiquitination-27.5021906983
146UbiquitinationIMNITEVKKIYKLSS
HHCHHHHHHHHHHCC		27.5027667366
147UbiquitinationMNITEVKKIYKLSSQ
HCHHHHHHHHHHCCC		57.3422817900
150UbiquitinationTEVKKIYKLSSQEES
HHHHHHHHHCCCHHH		45.4222817900
152PhosphorylationVKKIYKLSSQEESIG
HHHHHHHCCCHHHHH		26.3120068231
153PhosphorylationKKIYKLSSQEESIGT
HHHHHHCCCHHHHHH		52.6428348404
157PhosphorylationKLSSQEESIGTLLDA
HHCCCHHHHHHHHHH		26.0920068231
160PhosphorylationSQEESIGTLLDAIIC
CCHHHHHHHHHHHHH		23.6020068231
171PhosphorylationAIICRMSTKDVL---
HHHHCCCCCCCC---		23.1719369195
172UbiquitinationIICRMSTKDVL----
HHHCCCCCCCC----		38.23-
173UbiquitinationICRMSTKDVL-----
HHCCCCCCCC-----		47.2221963094
173 (in isoform 3)Ubiquitination-47.2221906983
185Ubiquitination-----------------
-----------------		22817900
185 (in isoform 3)Ubiquitination-21906983
186Ubiquitination------------------
------------------		22817900
189 (in isoform 3)Ubiquitination--
189Ubiquitination---------------------
---------------------		22817900
211 (in isoform 3)Ubiquitination--
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPRKB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPRKB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPRKB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRPK_HUMANTP53RKphysical
16189514
PRPK_HUMANTP53RKphysical
12659830
OSGEP_HUMANOSGEPphysical
22912744
LAGE3_HUMANLAGE3physical
22912744
PRPK_HUMANTP53RKphysical
22912744
UBE2S_HUMANUBE2Sphysical
22939629
TRM1_HUMANTRMT1physical
22939629
ARPC4_HUMANARPC4physical
22863883
ARPC5_HUMANARPC5physical
22863883
HSF1_HUMANHSF1physical
22863883
HPBP1_HUMANHSPBP1physical
22863883
KBP_HUMANKIAA1279physical
22863883
TRMB_HUMANMETTL1physical
22863883
NIF3L_HUMANNIF3L1physical
22863883
KAPCB_HUMANPRKACBphysical
22863883
RAGP1_HUMANRANGAP1physical
22863883
SH3G1_HUMANSH3GL1physical
22863883
SHLB1_HUMANSH3GLB1physical
22863883
PRPK_HUMANTP53RKphysical
22863883
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPRKB_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76; TYR-121; SER-132 ANDSER-152, AND MASS SPECTROMETRY.

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