dbPTM

ARPC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARPC5_HUMAN
UniProt AC	O15511
Protein Name	Actin-related protein 2/3 complex subunit 5
Gene Name	ARPC5
Organism	Homo sapiens (Human).
Sequence Length	151
Subcellular Localization	Cytoplasm, cytoskeleton . Cell projection .
Protein Description	Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks..
Protein Sequence	MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSKNTVSSA ------CCCCCCCCC	34.31	22814378
3	Sumoylation	-----MSKNTVSSAR -----CCCCCCCCCC	56.17	-
3	Ubiquitination	-----MSKNTVSSAR -----CCCCCCCCCC	56.17	24816145
3	Acetylation	-----MSKNTVSSAR -----CCCCCCCCCC	56.17	25953088
3	Sumoylation	-----MSKNTVSSAR -----CCCCCCCCCC	56.17	-
5	Phosphorylation	---MSKNTVSSARFR ---CCCCCCCCCCEE	26.04	30257219
5	O-linked_Glycosylation	---MSKNTVSSARFR ---CCCCCCCCCCEE	26.04	30379171
7	Phosphorylation	-MSKNTVSSARFRKV -CCCCCCCCCCEEEC	19.08	29514088
8	O-linked_Glycosylation	MSKNTVSSARFRKVD CCCCCCCCCCEEECC	21.08	30379171
8	Phosphorylation	MSKNTVSSARFRKVD CCCCCCCCCCEEECC	21.08	29514088
13	Ubiquitination	VSSARFRKVDVDEYD CCCCCEEECCHHHCC	39.82	33845483
19 (in isoform 2)	Phosphorylation	-	24.88	27642862
19	Phosphorylation	RKVDVDEYDENKFVD EECCHHHCCCCCCCC	24.88	28796482
23	Ubiquitination	VDEYDENKFVDEEDG HHHCCCCCCCCCCCC	44.72	29967540
23	Sumoylation	VDEYDENKFVDEEDG HHHCCCCCCCCCCCC	44.72	-
44	Phosphorylation	PDEGEVDSCLRQGNM CCCCCHHHHHHHCCH	21.89	-
51	Sulfoxidation	SCLRQGNMTAALQAA HHHHHCCHHHHHHHH	3.27	21406390
60 (in isoform 1)	Ubiquitination	-	63.78	21890473
60	Ubiquitination	AALQAALKNPPINTK HHHHHHHHCCCCCCC	63.78	21906983
67 (in isoform 1)	Ubiquitination	-	35.76	21890473
67	Ubiquitination	KNPPINTKSQAVKDR HCCCCCCCHHHHHHH	35.76	21906983
67	Acetylation	KNPPINTKSQAVKDR HCCCCCCCHHHHHHH	35.76	25953088
70	Ubiquitination	PINTKSQAVKDRAGS CCCCCHHHHHHHHHH	19.88	27667366
70 (in isoform 2)	Ubiquitination	-	19.88	21890473
72	Ubiquitination	NTKSQAVKDRAGSIV CCCHHHHHHHHHHHH	44.50	22505724
74	Methylation	KSQAVKDRAGSIVLK CHHHHHHHHHHHHHH	34.82	-
75	Ubiquitination	SQAVKDRAGSIVLKV HHHHHHHHHHHHHHH	26.64	23503661
77	Phosphorylation	AVKDRAGSIVLKVLI HHHHHHHHHHHHHHH	14.45	28355574
80 (in isoform 2)	Phosphorylation	-	2.79	27251275
85	Phosphorylation	IVLKVLISFKANDIE HHHHHHHHCHHCHHH	19.28	24719451
87	Ubiquitination	LKVLISFKANDIEKA HHHHHHCHHCHHHHH	39.22	33845483
87	Acetylation	LKVLISFKANDIEKA HHHHHHCHHCHHHHH	39.22	25953088
87	Malonylation	LKVLISFKANDIEKA HHHHHHCHHCHHHHH	39.22	26320211
90	Ubiquitination	LISFKANDIEKAVQS HHHCHHCHHHHHHHH	56.11	33845483
93	Ubiquitination	FKANDIEKAVQSLDK CHHCHHHHHHHHHHH	54.94	21906983
93	Acetylation	FKANDIEKAVQSLDK CHHCHHHHHHHHHHH	54.94	25953088
93 (in isoform 1)	Ubiquitination	-	54.94	21890473
96	Ubiquitination	NDIEKAVQSLDKNGV CHHHHHHHHHHHCCH	43.04	29967540
96 (in isoform 2)	Ubiquitination	-	43.04	21890473
100	Ubiquitination	KAVQSLDKNGVDLLM HHHHHHHHCCHHHHH	61.98	22505724
103	Ubiquitination	QSLDKNGVDLLMKYI HHHHHCCHHHHHHHH	7.01	22505724
108 (in isoform 1)	Ubiquitination	-	28.59	21890473
108	Ubiquitination	NGVDLLMKYIYKGFE CCHHHHHHHHHHCCC	28.59	21906983
111	Ubiquitination	DLLMKYIYKGFESPS HHHHHHHHHCCCCCC	11.28	21963094
111 (in isoform 2)	Ubiquitination	-	11.28	21890473
112 (in isoform 1)	Ubiquitination	-	47.79	21890473
112	Ubiquitination	LLMKYIYKGFESPSD HHHHHHHHCCCCCCC	47.79	22817900
115	Ubiquitination	KYIYKGFESPSDNSS HHHHHCCCCCCCCHH	71.10	22817900
115 (in isoform 2)	Ubiquitination	-	71.10	21890473
116	Phosphorylation	YIYKGFESPSDNSSA HHHHCCCCCCCCHHH	27.69	27251275
118	Phosphorylation	YKGFESPSDNSSAML HHCCCCCCCCHHHHH	59.72	22199227
119 (in isoform 2)	Phosphorylation	-	63.52	27251275
121	Phosphorylation	FESPSDNSSAMLLQW CCCCCCCHHHHHHHH	25.19	22199227
122	Phosphorylation	ESPSDNSSAMLLQWH CCCCCCHHHHHHHHH	24.77	22199227
124	Sulfoxidation	PSDNSSAMLLQWHEK CCCCHHHHHHHHHHH	4.08	30846556
131	Ubiquitination	MLLQWHEKALAAGGV HHHHHHHHHHHCCCH	35.49	22817900
131 (in isoform 1)	Ubiquitination	-	35.49	21890473
134 (in isoform 2)	Ubiquitination	-	14.66	21890473
134	Ubiquitination	QWHEKALAAGGVGSI HHHHHHHHCCCHHHH	14.66	21890473
140	Phosphorylation	LAAGGVGSIVRVLTA HHCCCHHHHHHHHHC	18.59	23312004
146	Phosphorylation	GSIVRVLTARKTV-- HHHHHHHHCCCCC--	22.89	23882029

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
77	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	RNF128	Q8TEB7	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARPC5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARPC5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARPC4_HUMAN	ARPC4	physical	12451597
ARPC4_HUMAN	ARPC4	physical	11162547
AASD1_HUMAN	AARSD1	physical	22863883
AN32B_HUMAN	ANP32B	physical	22863883
ARC1A_HUMAN	ARPC1A	physical	22863883
ARC1B_HUMAN	ARPC1B	physical	22863883
CALR_HUMAN	CALR	physical	22863883
2AAB_HUMAN	PPP2R1B	physical	22863883
KAPCA_HUMAN	PRKACA	physical	22863883
SH3G1_HUMAN	SH3GL1	physical	22863883
ARP3_HUMAN	ACTR3	physical	26344197
ARC1A_HUMAN	ARPC1A	physical	26344197
ARPC2_HUMAN	ARPC2	physical	26344197
ARPC4_HUMAN	ARPC4	physical	26344197
CAPZB_HUMAN	CAPZB	physical	26344197
ARP3B_HUMAN	ACTR3B	physical	28514442
HOIL1_HUMAN	RBCK1	physical	28514442
ARP3_HUMAN	ACTR3	physical	28514442
ARC1A_HUMAN	ARPC1A	physical	28514442
TROP_HUMAN	TRO	physical	28514442
ARPC3_HUMAN	ARPC3	physical	28514442
VP13A_HUMAN	VPS13A	physical	28514442
KPCD2_HUMAN	PRKD2	physical	28514442
UBB_HUMAN	UBB	physical	28514442
MKS1_HUMAN	MKS1	physical	28514442
VP13C_HUMAN	VPS13C	physical	28514442
DPOA2_HUMAN	POLA2	physical	28514442
RAD21_HUMAN	RAD21	physical	28514442
HUS1_HUMAN	HUS1	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
MAPK2_HUMAN	MAPKAPK2	physical	12829704

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARPC5_HUMAN

Related Literatures of Post-Translational Modification