ARP3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARP3B_HUMAN
• UniProt AC: Q9P1U1
• Protein Name: Actin-related protein 3B
• Gene Name: ACTR3B
• Organism: Homo sapiens (Human).
• Sequence Length: 418
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection.
• Protein Description: Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors..
• Protein Sequence: MAGSLPPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVVDQAQRRVLRGVDDLDFFIGDEAIDKPTYATKWPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGSLPPCV ------CCCCCCCEE	19.11	-
16	Phosphorylation	VVDCGTGYTKLGYAG EEECCCCCEECCCCC	10.67	18083107
69	Ubiquitination	IGDEAIDKPTYATKW ECCCCCCCCCCCCCC	32.90	-
133	Phosphorylation	LAEIMFESFNVPGLY HHHHHHHHCCCCHHH	15.74	-
140	Phosphorylation	SFNVPGLYIAVQAVL HCCCCHHHHHHHHHH	7.86	-
152	Phosphorylation	AVLALAASWTSRQVG HHHHHHHHHHCCCCC	25.86	-
184	Phosphorylation	VIPVAEGYVIGSCIK EEEECCCEEEHHHHH	4.76	20090780
188	Phosphorylation	AEGYVIGSCIKHIPI CCCEEEHHHHHCCCC	11.09	-
201	Phosphorylation	PIAGRDITYFIQQLL CCCCCHHHHHHHHHH	19.37	28450419
202	Phosphorylation	IAGRDITYFIQQLLR CCCCHHHHHHHHHHH	10.06	22115753
230	Ubiquitination	TAKAIKEKYCYICPD HHHHHHHHHEEECHH	35.30	-
231	Phosphorylation	AKAIKEKYCYICPDI HHHHHHHHEEECHHH	7.50	21082442
240	Acetylation	YICPDIVKEFAKYDV EECHHHHHHHHHCCC	47.66	-
244	Acetylation	DIVKEFAKYDVDPRK HHHHHHHHCCCCHHH	47.51	-
244	Ubiquitination	DIVKEFAKYDVDPRK HHHHHHHHCCCCHHH	47.51	-
251	Acetylation	KYDVDPRKWIKQYTG HCCCCHHHHHHHHHC	59.67	-
254	Acetylation	VDPRKWIKQYTGINA CCHHHHHHHHHCCCC	35.82	-
254	Ubiquitination	VDPRKWIKQYTGINA CCHHHHHHHHHCCCC	35.82	-
256	Phosphorylation	PRKWIKQYTGINAIN HHHHHHHHHCCCCCC	11.26	11172439
265	Ubiquitination	GINAINQKKFVIDVG CCCCCCCCEEEEEEC	43.63	-
266	Ubiquitination	INAINQKKFVIDVGY CCCCCCCEEEEEECH	34.79	-
293	Sulfoxidation	EFANPDFMESISDVV HHCCHHHHHHHHHHH	5.28	10
354	Phosphorylation	LRLSEELSGGRIKPK HHCCHHHCCCCCCCC	42.34	63650335
398	Ubiquitination	FQVCHTKKDYEEYGP HHHHCCCCCHHHHCC	67.70	-
403	Phosphorylation	TKKDYEEYGPSICRH CCCCHHHHCCCCCCC	23.54	153589
418	Phosphorylation	NPVFGVMS------- CCCCCCCC-------	34.36	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARP3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARP3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARP3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARPC2_HUMAN	ARPC2	physical	17353931
ARC1A_HUMAN	ARPC1A	physical	17353931
ARP2_HUMAN	ACTR2	physical	17353931
ARPC4_HUMAN	ARPC4	physical	17353931
ARC1B_HUMAN	ARPC1B	physical	17353931
CDK4_HUMAN	CDK4	physical	17353931
ARP5L_HUMAN	ARPC5L	physical	17353931
ARPC3_HUMAN	ARPC3	physical	17353931
ARPC5_HUMAN	ARPC5	physical	17353931
TWF2_HUMAN	TWF2	physical	17353931
CCAR2_HUMAN	CCAR2	physical	17353931
EXOC5_HUMAN	EXOC5	physical	21988832
ARP2_HUMAN	ACTR2	physical	28514442
ARPC2_HUMAN	ARPC2	physical	28514442
CHUR_HUMAN	CHURC1	physical	28514442
OSBL3_HUMAN	OSBPL3	physical	28514442
ARP3_HUMAN	ACTR3	physical	28514442
ARP5L_HUMAN	ARPC5L	physical	28514442
ARPC4_HUMAN	ARPC4	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPQ_HUMAN	CCT8	physical	28514442
PHLP_HUMAN	PDCL	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.