dbPTM

CDK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDK4_HUMAN
UniProt AC	P11802
Protein Name	Cyclin-dependent kinase 4
Gene Name	CDK4
Organism	Homo sapiens (Human).
Sequence Length	303
Subcellular Localization	Cytoplasm. Nucleus. Membrane. Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S pha
Protein Description	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex..
Protein Sequence	MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATSRYEPV ------CCCCCCCCC	17.81	19413330
17	Phosphorylation	AEIGVGAYGTVYKAR EEEECEECEEEEEEC	13.85	22817900
22	Ubiquitination	GAYGTVYKARDPHSG EECEEEEEECCCCCC	32.39	21906983
22	Ubiquitination	GAYGTVYKARDPHSG EECEEEEEECCCCCC	32.39	-
28	Phosphorylation	YKARDPHSGHFVALK EEECCCCCCCEEEEE	39.07	20873877
35	Ubiquitination	SGHFVALKSVRVPNG CCCEEEEEEEECCCC	36.85	21890473
35	Ubiquitination	SGHFVALKSVRVPNG CCCEEEEEEEECCCC	36.85	21890473
35	Ubiquitination	SGHFVALKSVRVPNG CCCEEEEEEEECCCC	36.85	21890473
35	Ubiquitination	SGHFVALKSVRVPNG CCCEEEEEEEECCCC	36.85	21906983
91	Ubiquitination	DREIKVTLVFEHVDQ CCEEEEEEEEEECCH	4.68	-
101	Methylation	EHVDQDLRTYLDKAP EECCHHHHHHHHHCC	29.61	-
102	Phosphorylation	HVDQDLRTYLDKAPP ECCHHHHHHHHHCCC	35.42	20071362
103	Phosphorylation	VDQDLRTYLDKAPPP CCHHHHHHHHHCCCC	13.38	29496907
106	Ubiquitination	DLRTYLDKAPPPGLP HHHHHHHHCCCCCCC	61.26	21906983
118	Ubiquitination	GLPAETIKDLMRQFL CCCHHHHHHHHHHHH	52.83	21906983
142	Ubiquitination	CIVHRDLKPENILVT EEECCCCCHHHEEEE	55.35	21906983
150	Phosphorylation	PENILVTSGGTVKLA HHHEEEECCCEEEHH	27.96	20873877
153	Phosphorylation	ILVTSGGTVKLADFG EEEECCCEEEHHHHC	20.28	20873877
155	Ubiquitination	VTSGGTVKLADFGLA EECCCEEEHHHHCHH	37.48	21906983
165	Phosphorylation	DFGLARIYSYQMALT HHCHHHHEEHHHCCC	8.86	25262027
166	Phosphorylation	FGLARIYSYQMALTP HCHHHHEEHHHCCCC	13.40	25262027
167	Phosphorylation	GLARIYSYQMALTPV CHHHHEEHHHCCCCH	5.83	25262027
169	Sulfoxidation	ARIYSYQMALTPVVV HHHEEHHHCCCCHHH	2.21	28183972
172	Phosphorylation	YSYQMALTPVVVTLW EEHHHCCCCHHHHHH	12.42	9311594
177	Phosphorylation	ALTPVVVTLWYRAPE CCCCHHHHHHHCCCH	10.44	25262027
177	Ubiquitination	ALTPVVVTLWYRAPE CCCCHHHHHHHCCCH	10.44	-
180	Phosphorylation	PVVVTLWYRAPEVLL CHHHHHHHCCCHHHH	10.46	25262027
211	Ubiquitination	FAEMFRRKPLFCGNS HHHHHHCCCCCCCCC	41.64	21890473
243	Phosphorylation	DDWPRDVSLPRGAFP CCCCCCCCCCCCCCC	36.62	24719451
277	Phosphorylation	QLLLEMLTFNPHKRI HHHHHHHHCCHHHHH	21.76	20071362
282	Ubiquitination	MLTFNPHKRISAFRA HHHCCHHHHHHHHHH	53.32	-
285	Phosphorylation	FNPHKRISAFRALQH CCHHHHHHHHHHHHH	25.95	24719451
293	Phosphorylation	AFRALQHSYLHKDEG HHHHHHHHHHCCCCC	19.21	20873877
297	Ubiquitination	LQHSYLHKDEGNPE- HHHHHHCCCCCCCC-	55.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
17	Y	Phosphorylation	Kinase	LYN	P07948	PSP
17	Y	Phosphorylation	Kinase	SRC	P12931	PSP
17	Y	Phosphorylation	Kinase	YES1	P07947	GPS
17	Y	Phosphorylation	Kinase	SRC-FAMILY	-	GPS
172	T	Phosphorylation	Kinase	CDK7	P50613	PSP
172	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
172	T	Phosphorylation	Kinase	MAPK9	P45984	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
172	T	Phosphorylation	16782892
In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B.
172	T	Phosphorylation	16782892
Phosphorylation at Thr-172 is required for enzymatic activity.
172	T	Phosphorylation	16782892
Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDK4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDN2D_HUMAN	CDKN2D	physical	16189514
VTA1_HUMAN	VTA1	physical	16189514
CDN2B_HUMAN	CDKN2B	physical	16189514
CDC37_HUMAN	CDC37	physical	17353931
CDN2A_HUMAN	CDKN2A	physical	17353931
ARF_HUMAN	CDKN2A	physical	17353931
CDN2C_HUMAN	CDKN2C	physical	17353931
SMC3_HUMAN	SMC3	physical	17353931
RPRM_HUMAN	RPRM	physical	17353931
DBNL_HUMAN	DBNL	physical	17353931
GEMI4_HUMAN	GEMIN4	physical	17353931
UBXN1_HUMAN	UBXN1	physical	17353931
SMC1A_HUMAN	SMC1A	physical	17353931
LYN_HUMAN	LYN	physical	17353931
BAG6_HUMAN	BAG6	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
CPNS1_HUMAN	CAPNS1	physical	16169070
CDN2B_HUMAN	CDKN2B	physical	16169070
CCND1_HUMAN	CCND1	physical	10580009
CDN2A_HUMAN	CDKN2A	physical	8259215
ARF_HUMAN	CDKN2A	physical	8259215
PCNA_HUMAN	PCNA	physical	8259215
CCND1_HUMAN	CCND1	physical	8259215
CCND1_HUMAN	CCND1	physical	11360184
CCND2_HUMAN	CCND2	physical	11360184
CCND3_HUMAN	CCND3	physical	11360184
CCND3_HUMAN	CCND3	physical	10342870
CDC37_HUMAN	CDC37	physical	8703009
RFC1_HUMAN	RFC1	physical	10353443
CDC37_HUMAN	CDC37	physical	9150368
CDN1B_HUMAN	CDKN1B	physical	10908655
CCND1_HUMAN	CCND1	physical	10908655
CCND1_HUMAN	CCND1	physical	9228064
CDN2A_HUMAN	CDKN2A	physical	9228064
ARF_HUMAN	CDKN2A	physical	9228064
CDC37_HUMAN	CDC37	physical	8666233
PCNA_HUMAN	PCNA	physical	8101826
RB_HUMAN	RB1	physical	19225156
CDN1B_HUMAN	CDKN1B	physical	15695403
CDN1A_HUMAN	CDKN1A	physical	15695403
HSP7C_HUMAN	HSPA8	physical	18537972
CCND1_HUMAN	CCND1	physical	18537972
TSYL2_HUMAN	TSPYL2	physical	11395479
RB_HUMAN	RB1	physical	15003538
BRCA1_HUMAN	BRCA1	physical	17334399
CCND1_HUMAN	CCND1	physical	9372967
CCND1_HUMAN	CCND1	physical	20837141
CDN1B_HUMAN	CDKN1B	physical	20837141
CDN1A_HUMAN	CDKN1A	physical	17556661
CDN2B_HUMAN	CDKN2B	physical	21900206
APLP1_HUMAN	APLP1	physical	21900206
DDAH2_HUMAN	DDAH2	physical	21900206
ZBT16_HUMAN	ZBTB16	physical	21900206
SYQ_HUMAN	QARS	physical	21900206
HMGX3_HUMAN	HMGXB3	physical	21900206
TRM2A_HUMAN	TRMT2A	physical	21900206
ATPB_HUMAN	ATP5B	physical	21900206
KPYM_HUMAN	PKM	physical	21900206
LC7L2_HUMAN	LUC7L2	physical	21900206
SETB1_HUMAN	SETDB1	physical	21900206
CDN1A_HUMAN	CDKN1A	physical	18850315
CDN1B_HUMAN	CDKN1B	physical	18850315
H13_HUMAN	HIST1H1D	physical	18850315
RB_HUMAN	RB1	physical	16205633
RB_HUMAN	RB1	physical	15169570
CCND2_HUMAN	CCND2	physical	15169570
RB_HUMAN	RB1	physical	12949733
PSMD9_HUMAN	PSMD9	physical	12684681
RB_HUMAN	RB1	physical	12519773
H11_HUMAN	HIST1H1A	physical	11132966
CD5R1_HUMAN	CDK5R1	physical	22654103
MARCS_HUMAN	MARCKS	physical	10359664
CDN1B_HUMAN	CDKN1B	physical	18615582
RB_HUMAN	RB1	physical	10198259
CDN1B_HUMAN	CDKN1B	physical	10198259
CDN1A_HUMAN	CDKN1A	physical	9658399
CDN1B_HUMAN	CDKN1B	physical	9658399
CDN1A_HUMAN	CDKN1A	physical	9632134
CDN1B_HUMAN	CDKN1B	physical	9632134
RB_HUMAN	RB1	physical	8647086
CCND1_HUMAN	CCND1	physical	8867812
RB_HUMAN	RB1	physical	8867812
H11_HUMAN	HIST1H1A	physical	10447003
RB_HUMAN	RB1	physical	15998794
H10_HUMAN	H1F0	physical	12383116
RB_HUMAN	RB1	physical	12190313
CDN2A_HUMAN	CDKN2A	physical	11900540
ARF_HUMAN	CDKN2A	physical	11900540
CDN2C_HUMAN	CDKN2C	physical	11900540
PSD10_HUMAN	PSMD10	physical	11900540
RB_HUMAN	RB1	physical	11900540
CCND3_HUMAN	CCND3	physical	16985050
CCND1_HUMAN	CCND1	physical	16985050
RB_HUMAN	RB1	physical	16985050
RB_HUMAN	RB1	physical	19556892
BRCA1_HUMAN	BRCA1	physical	12509456
RB_HUMAN	RB1	physical	12509456
RB_HUMAN	RB1	physical	15147269
CDC37_HUMAN	CDC37	physical	11867521
HS90A_HUMAN	HSP90AA1	physical	11867521
CEBPA_HUMAN	CEBPA	physical	11867521
CDN2A_HUMAN	CDKN2A	physical	10719365
ARF_HUMAN	CDKN2A	physical	10719365
RB_HUMAN	RB1	physical	15922743
RB_HUMAN	RB1	physical	9199321
H11_HUMAN	HIST1H1A	physical	9464540
CDN1A_HUMAN	CDKN1A	physical	9464540
RB_HUMAN	RB1	physical	9464540
CDN1B_HUMAN	CDKN1B	physical	9464540
A4_HUMAN	APP	physical	21832049
PP1A_HUMAN	PPP1CA	physical	22939629
RB_HUMAN	RB1	physical	10202152
UBF1_HUMAN	UBTF	physical	10202152
RB_HUMAN	RB1	physical	17015477
DPOD1_HUMAN	POLD1	physical	9545286
RB_HUMAN	RB1	physical	9190208
SMAD3_HUMAN	SMAD3	physical	15241418
SMAD2_HUMAN	SMAD2	physical	15241418
RB_HUMAN	RB1	physical	15241418
CDN1A_HUMAN	CDKN1A	physical	8756624
RB_HUMAN	RB1	physical	8756624
RB_HUMAN	RB1	physical	9003781
CDN2A_HUMAN	CDKN2A	physical	17909018
ARF_HUMAN	CDKN2A	physical	17909018
RB_HUMAN	RB1	physical	22094256
FOXM1_HUMAN	FOXM1	physical	22094256
CDC6_HUMAN	CDC6	physical	22094256
GLI1_HUMAN	GLI1	physical	22094256
MYC_HUMAN	MYC	physical	22094256
OTX2_HUMAN	OTX2	physical	22094256
RBL1_HUMAN	RBL1	physical	22094256
RBL2_HUMAN	RBL2	physical	22094256
SHOX2_HUMAN	SHOX2	physical	22094256
MZF1_HUMAN	MZF1	physical	22094256
SLBP_HUMAN	SLBP	physical	22094256
ANR12_HUMAN	ANKRD12	physical	22094256
SENP3_HUMAN	SENP3	physical	22094256
ZN219_HUMAN	ZNF219	physical	22094256
BC11A_HUMAN	BCL11A	physical	22094256
WDR33_HUMAN	WDR33	physical	22094256
ZN335_HUMAN	ZNF335	physical	22094256
ZN101_HUMAN	ZNF101	physical	22094256
MCM2_HUMAN	MCM2	physical	15232106
CDN1A_HUMAN	CDKN1A	physical	15232106
CDC7_HUMAN	CDC7	physical	15232106
RB_HUMAN	RB1	physical	12676926
CDN2B_HUMAN	CDKN2B	physical	19447967
RB_MOUSE	Rb1	physical	9840932
CCND1_HUMAN	CCND1	physical	19470470
CDN1B_HUMAN	CDKN1B	physical	19470470
RB_HUMAN	RB1	physical	16326706
RB_HUMAN	RB1	physical	23543736
RB_HUMAN	RB1	physical	16962592
RB_HUMAN	RB1	physical	17053782
CDN1B_HUMAN	CDKN1B	physical	17053782
RB_HUMAN	RB1	physical	9139732
CDN2D_HUMAN	CDKN2D	physical	23718855
RB_HUMAN	RB1	physical	10486249
CDN1B_HUMAN	CDKN1B	physical	23707388
CCND1_HUMAN	CCND1	physical	23707388
I15RA_HUMAN	IL15RA	physical	21988832
CDN2C_HUMAN	CDKN2C	physical	21988832
DUS9_HUMAN	DUSP9	physical	21988832
MYC_HUMAN	MYC	physical	21988832
6PGD_HUMAN	PGD	physical	21988832
SKP1_HUMAN	SKP1	physical	21988832
CIB1_HUMAN	CIB1	physical	21988832
MARE2_HUMAN	MAPRE2	physical	21988832
CDN2B_HUMAN	CDKN2B	physical	23602568
CDN2A_HUMAN	CDKN2A	physical	23602568
ARF_HUMAN	CDKN2A	physical	23602568
CDN2C_HUMAN	CDKN2C	physical	23602568
CDK13_HUMAN	CDK13	physical	23602568
CDN2D_HUMAN	CDKN2D	physical	23602568
CDN1B_HUMAN	CDKN1B	physical	23602568
HS90A_HUMAN	HSP90AA1	physical	23455922
HS90B_HUMAN	HSP90AB1	physical	23455922
CDN2A_HUMAN	CDKN2A	physical	23455922
ARF_HUMAN	CDKN2A	physical	23455922
CDN2B_HUMAN	CDKN2B	physical	23455922
CDN2C_HUMAN	CDKN2C	physical	23455922
CDK6_HUMAN	CDK6	physical	23455922
TRAP1_HUMAN	TRAP1	physical	23455922
CDN2C_HUMAN	CDKN2C	physical	25416956
CDN2D_HUMAN	CDKN2D	physical	25416956
HOOK1_HUMAN	HOOK1	physical	25416956
RB_HUMAN	RB1	physical	16878158
H11_HUMAN	HIST1H1A	physical	16878158
RB_HUMAN	RB1	physical	15695403
HS90A_HUMAN	HSP90AA1	physical	26186194
HS90B_HUMAN	HSP90AB1	physical	26186194
OGFR_HUMAN	OGFR	physical	26186194
FKBP5_HUMAN	FKBP5	physical	26186194
CDC37_HUMAN	CDC37	physical	26186194
IF1AX_HUMAN	EIF1AX	physical	26186194
BGLR_HUMAN	GUSB	physical	26186194
OGRL1_HUMAN	OGFRL1	physical	26186194
CDN2B_HUMAN	CDKN2B	physical	26186194
CDN2A_HUMAN	CDKN2A	physical	26186194
ARF_HUMAN	CDKN2A	physical	26186194
JAK3_HUMAN	JAK3	physical	26186194
CDN2C_HUMAN	CDKN2C	physical	26186194
CDN2D_HUMAN	CDKN2D	physical	26186194
CDN1B_HUMAN	CDKN1B	physical	26186194
ALR_HUMAN	GFER	physical	26186194
CCND3_HUMAN	CCND3	physical	21516116
CCND3_HUMAN	CCND3	physical	26496610
CDN2A_HUMAN	CDKN2A	physical	26496610
ARF_HUMAN	CDKN2A	physical	26496610
CDN2B_HUMAN	CDKN2B	physical	26496610
SMTN_HUMAN	SMTN	physical	26496610
CDK13_HUMAN	CDK13	physical	26496610
SRBS1_HUMAN	SORBS1	physical	26496610
NU133_HUMAN	NUP133	physical	26496610
ZNFX1_HUMAN	ZNFX1	physical	26496610
ZC3HE_HUMAN	ZC3H14	physical	26496610
T126A_HUMAN	TMEM126A	physical	26496610
ASPM_HUMAN	ASPM	physical	26496610
CDN1B_HUMAN	CDKN1B	physical	25241761
CCND1_HUMAN	CCND1	physical	25241761
SMAD3_HUMAN	SMAD3	physical	25241761
RB_HUMAN	RB1	physical	19767775
RB_HUMAN	RB1	physical	11287611
CDN1A_HUMAN	CDKN1A	physical	23007395
VHL_HUMAN	VHL	genetic	28319113
HDAC1_HUMAN	HDAC1	genetic	28319113
PRKDC_HUMAN	PRKDC	genetic	28319113
CHK2_HUMAN	CHEK2	genetic	28319113
ERBB2_HUMAN	ERBB2	genetic	28319113
TOP1_HUMAN	TOP1	genetic	28319113
PTEN_HUMAN	PTEN	genetic	28319113
YBOX3_HUMAN	YBX3	physical	10100871
U17L2_HUMAN	USP17L2	physical	28067227
OGRL1_HUMAN	OGFRL1	physical	28514442
CDN2B_HUMAN	CDKN2B	physical	28514442
CDN2A_HUMAN	CDKN2A	physical	28514442
ARF_HUMAN	CDKN2A	physical	28514442
CDN1B_HUMAN	CDKN1B	physical	28514442
FKBP5_HUMAN	FKBP5	physical	28514442
HS90A_HUMAN	HSP90AA1	physical	28514442
JAK3_HUMAN	JAK3	physical	28514442
HS90B_HUMAN	HSP90AB1	physical	28514442
BGLR_HUMAN	GUSB	physical	28514442
ALR_HUMAN	GFER	physical	28514442
CDC37_HUMAN	CDC37	physical	28514442
CDN1A_HUMAN	CDKN1A	physical	28514442
CDN2D_HUMAN	CDKN2D	physical	28514442
CCND2_HUMAN	CCND2	physical	17873913
RB_HUMAN	RB1	physical	17873913
DNJC9_HUMAN	DNAJC9	physical	27173435
RB_HUMAN	RB1	physical	11306463
CCND1_HUMAN	CCND1	physical	11463845

Drug and Disease Associations

Kegg Disease
H00030	Cervical cancer
H00038	Malignant melanoma
H00042	Glioma
OMIM Disease
609048	Melanoma, cutaneous malignant 3 (CMM3)
Kegg Drug
D10372	Palbociclib (USAN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDK4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150 AND THR-172, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"The structure of CDK4/cyclin D3 has implications for models of CDKactivation."; Takaki T., Echalier A., Brown N.R., Hunt T., Endicott J.A.,Noble M.E.; Proc. Natl. Acad. Sci. U.S.A. 106:4171-4176(2009). Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF NONPHOSPHORYLATED FORM INCOMPLEX WITH CCND3, PHOSPHORYLATION AT THR-172, AND MASS SPECTROMETRY.	19237555 [Abstract]
"Crystal structure of human CDK4 in complex with a D-type cyclin."; Day P.J., Cleasby A., Tickle I.J., O'Reilly M., Coyle J.E.,Holding F.P., McMenamin R.L., Yon J., Chopra R., Lengauer C.,Jhoti H.; Proc. Natl. Acad. Sci. U.S.A. 106:4166-4170(2009). Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF THR-172-PHOSPHORYLATED WILDTYPE AND MUTANTS ALA-172; PHE-172 AND ASP-172 IN COMPLEX WITH CCND1,MASS SPECTROMETRY, PHOSPHORYLATION AT THR-172, AND CATALYTIC ACTIVITY.	19237565 [Abstract]
"Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6,evidence that CDK4 might not be activated by CDK7, and design of aCDK6 activating mutation."; Bockstaele L., Bisteau X., Paternot S., Roger P.P.; Mol. Cell. Biol. 29:4188-4200(2009). Cited for: PHOSPHORYLATION AT THR-172, ENZYME REGULATION, AND MUTAGENESIS OFPRO-173.	19487459 [Abstract]
"Regulated activating Thr172 phosphorylation of cyclin-dependentkinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'."; Bockstaele L., Kooken H., Libert F., Paternot S., Dumont J.E.,de Launoit Y., Roger P.P., Coulonval K.; Mol. Cell. Biol. 26:5070-5085(2006). Cited for: PHOSPHORYLATION AT THR-172, INTERACTION WITH CCND1; CCND3; CDKN2A ANDCDKN1B, AND MUTAGENESIS OF THR-172.	16782892 [Abstract]

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