| UniProt ID | CDN2B_HUMAN | |
|---|---|---|
| UniProt AC | P42772 | |
| Protein Name | Cyclin-dependent kinase 4 inhibitor B | |
| Gene Name | CDKN2B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 138 | |
| Subcellular Localization | Cytoplasm . Also found in the nucleus. | |
| Protein Description | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.. | |
| Protein Sequence | MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 74 | S-nitrosocysteine | LHGAEPNCADPATLT HCCCCCCCCCCHHCC | 7.13 | - | |
| 74 | S-nitrosylation | LHGAEPNCADPATLT HCCCCCCCCCCHHCC | 7.13 | 19483679 | |
| 101 | Methylation | DTLVVLHRAGARLDV HHHHHHHHCCCCCCH | 30.47 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDN2B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDN2B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDN2B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MAGAB_HUMAN | MAGEA11 | physical | 16189514 | |
| ELP1_HUMAN | IKBKAP | physical | 16169070 | |
| CC90B_HUMAN | CCDC90B | physical | 16169070 | |
| CE126_HUMAN | KIAA1377 | physical | 16169070 | |
| A4_HUMAN | APP | physical | 21832049 | |
| P5CR3_HUMAN | PYCRL | physical | 23718855 | |
| ISL1_HUMAN | ISL1 | physical | 21988832 | |
| TGFI1_HUMAN | TGFB1I1 | physical | 21988832 | |
| TRAF1_HUMAN | TRAF1 | physical | 25416956 | |
| NIF3L_HUMAN | NIF3L1 | physical | 25416956 | |
| CCD33_HUMAN | CCDC33 | physical | 25416956 | |
| CDK6_HUMAN | CDK6 | physical | 26578655 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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