CC90B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC90B_HUMAN
• UniProt AC: Q9GZT6
• Protein Name: Coiled-coil domain-containing protein 90B, mitochondrial
• Gene Name: CCDC90B
• Organism: Homo sapiens (Human).
• Sequence Length: 254
• Subcellular Localization: Mitochondrion membrane ; Single-pass membrane protein .
• Protein Sequence: MNSRQAWRLFLSQGRGDRWVSRPRGHFSPALRREFFTTTTKEGYDRRPVDITPLEQRKLTFDTHALVQDLETHGFDKTQAETIVSALTALSNVSLDTIYKEMVTQAQQEITVQQLMAHLDAIRKDMVILEKSEFANLRAENEKMKIELDQVKQQLMHETSRIRADNKLDINLERSRVTDMFTDQEKQLMETTTEFTKKDTQTKSIISETSNKIDAEIASLKTLMESNKLETIRYLAASVFTCLAIALGFYRFWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	QAWRLFLSQGRGDRW HHHHHHHHCCCCCCC	24.21	24719451
37	Phosphorylation	ALRREFFTTTTKEGY HHHHHHHCCCCCCCC	28.67	-
52	Ubiquitination	DRRPVDITPLEQRKL CCCCCCCCCHHHCCC	19.84	29967540
66	Ubiquitination	LTFDTHALVQDLETH CCCCHHHHHHHHHHC	2.49	29967540
69	Ubiquitination	DTHALVQDLETHGFD CHHHHHHHHHHCCCC	38.71	29967540
104	Phosphorylation	TIYKEMVTQAQQEIT HHHHHHHHHHHHHCH	19.51	17525332
158	Ubiquitination	VKQQLMHETSRIRAD HHHHHHHHHHHHHHC	34.22	29967540
167	Ubiquitination	SRIRADNKLDINLER HHHHHCCCCCCCCHH	48.35	29967540
175	Phosphorylation	LDINLERSRVTDMFT CCCCCHHHHHHHHCC	23.02	26074081
182	Phosphorylation	SRVTDMFTDQEKQLM HHHHHHCCHHHHHHH	30.09	-
193	Phosphorylation	KQLMETTTEFTKKDT HHHHHHHCCHHHHHH	36.20	-
196	Phosphorylation	METTTEFTKKDTQTK HHHHCCHHHHHHHHH	30.84	-
219	Phosphorylation	KIDAEIASLKTLMES HHHHHHHHHHHHHHC	35.74	30266825
222	Phosphorylation	AEIASLKTLMESNKL HHHHHHHHHHHCCCH	36.31	-
231	Phosphorylation	MESNKLETIRYLAAS HHCCCHHHHHHHHHH	22.61	-
234	Phosphorylation	NKLETIRYLAASVFT CCHHHHHHHHHHHHH	9.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC90B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC90B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC90B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MCUR1_HUMAN	MCUR1	physical	26186194
MCUR1_HUMAN	MCUR1	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-104, AND MASSSPECTROMETRY.
PubMed: 17525332