MCUR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCUR1_HUMAN
• UniProt AC: Q96AQ8
• Protein Name: Mitochondrial calcium uniporter regulator 1 {ECO:0000303|PubMed:23178883}
• Gene Name: MCUR1 {ECO:0000303|PubMed:23178883}
• Organism: Homo sapiens (Human).
• Sequence Length: 359
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. [PubMed: 23178883]
• Protein Sequence: MDCGSVGGQRTQRLPGRQRLLFLPVGLSGRPGGSETSARRCLSALSDGLGALRPRAPAARGGVSRASPLLLLLLVPSPRLAAAAPRRQLGDWERSRLGYAAPPAGRSSAWRCSPGVAAAAGALPQYHGPAPALVSCRRELSLSAGSLQLERKRRDFTSSGSRKLYFDTHALVCLLEDNGFATQQAEIIVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDMIILEKSEFSALRAENEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEKSRVKELYSLNEKKLLELRTEIVALHAQQDRALTQTDRKIETEVAGLKTMLESHKLDNIKYLAGSIFTCLTVALGFYRLWI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	LSGRPGGSETSARRC CCCCCCCCHHHHHHH		28787133
37	Phosphorylation	RPGGSETSARRCLSA CCCCCHHHHHHHHHH		28787133
43	Phosphorylation	TSARRCLSALSDGLG HHHHHHHHHHHCCCC		28787133
99	Phosphorylation	WERSRLGYAAPPAGR CHHHCCCCCCCCCCC		22210691
107	Phosphorylation	AAPPAGRSSAWRCSP CCCCCCCCCCCCCCH		22210691
141	Phosphorylation	VSCRRELSLSAGSLQ HHHCHHHHHCCCCCE		24114839
143	Phosphorylation	CRRELSLSAGSLQLE HCHHHHHCCCCCEEE		24114839
161	Phosphorylation	RDFTSSGSRKLYFDT CCCCCCCCEEEEEEC		19651622
216	Phosphorylation	TKMQQEITFQQVMSQ HHHHHHHHHHHHHHH		-
240	Phosphorylation	ILEKSEFSALRAENE EEEHHHHHHHHHHHH		24719451
279	Ubiquitination	KLDFNLEKSRVKELY CCCCCCCHHHHHHHH		-
280	Phosphorylation	LDFNLEKSRVKELYS CCCCCCHHHHHHHHC		26270265
283	Ubiquitination	NLEKSRVKELYSLNE CCCHHHHHHHHCCCH		-
286	Phosphorylation	KSRVKELYSLNEKKL HHHHHHHHCCCHHHH		26270265
287	Phosphorylation	SRVKELYSLNEKKLL HHHHHHHCCCHHHHH		26270265
291	Ubiquitination	ELYSLNEKKLLELRT HHHCCCHHHHHHHHH		-
317	Ubiquitination	ALTQTDRKIETEVAG HCHHHCHHHHHHHHH		-
320	Phosphorylation	QTDRKIETEVAGLKT HHCHHHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCUR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCUR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCUR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPT2_HUMAN	CPT2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.