dbPTM

MZF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MZF1_HUMAN
UniProt AC	P28698
Protein Name	Myeloid zinc finger 1
Gene Name	MZF1
Organism	Homo sapiens (Human).
Sequence Length	734
Subcellular Localization	Nucleus.
Protein Description	Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development..
Protein Sequence	MRPAVLGSPDRAPPEDEGPVMVKLEDSEEEGEAALWDPGPEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALVDGLRREPGGPRRWVTVQVQGQEVLSEKMEPSSFQPLPETEPPTPEPGPKTPPRTMQESPLGLQVKEESEVTEDSDFLESGPLAATQESVPTLLPEEAQRCGTVLDQIFPHSKTGPEGPSWREHPRALWHEEAGGIFSPGFALQLGSISAGPGSVSPHLHVPWDLGMAGLSGQIQSPSREGGFAHALLLPSDLRSEQDPTDEDPCRGVGPALITTRWRSPRGRSRGRPSTGGGVVRGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCSECGRSFSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEEHRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGDPPGPGAKPPAPPGAPEPPGPFPCSECRESFARRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQHRRIHTGERPFACAECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRFSQRLKLTRHQRTHTGEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLTQHRRIHTGERPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQSTKLIQHQRVHSAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MRPAVLGSPDRAPPE CCCCCCCCCCCCCCC	21.33	24719451
27	Phosphorylation	VMVKLEDSEEEGEAA EEEEECCCCCCCCCC	37.22	22798277
111	Phosphorylation	VQGQRPGSPEEAAAL HCCCCCCCHHHHHHH	31.64	28112733
134	Phosphorylation	GGPRRWVTVQVQGQE CCCCEEEEEEECCEE	9.77	23312004
150	Phosphorylation	LSEKMEPSSFQPLPE HHCCCCCCCCCCCCC	30.40	23312004
151	Phosphorylation	SEKMEPSSFQPLPET HCCCCCCCCCCCCCC	38.32	23312004
158	Phosphorylation	SFQPLPETEPPTPEP CCCCCCCCCCCCCCC	52.42	23312004
162	Phosphorylation	LPETEPPTPEPGPKT CCCCCCCCCCCCCCC	51.50	23312004
169	Phosphorylation	TPEPGPKTPPRTMQE CCCCCCCCCCCCCCC	41.48	27050516
173	Phosphorylation	GPKTPPRTMQESPLG CCCCCCCCCCCCCCC	29.04	23186163
177	Phosphorylation	PPRTMQESPLGLQVK CCCCCCCCCCCCEEC	14.45	25849741
238	Phosphorylation	KTGPEGPSWREHPRA CCCCCCCCHHHCCCH	50.01	26091039
347	Phosphorylation	GRSRGRPSTGGGVVR CCCCCCCCCCCCCCC	38.02	22817900
394	Phosphorylation	SECGRSFSRSSHLLR CCCCCCCCHHHHHHH	32.28	17081983
453	Phosphorylation	GQSFRQRSNLLQHQR CCHHHHHHHHHHHCH	24.40	-
592	Phosphorylation	TQHLRVHTGEKPFAC CHHEEEECCCCCCCC	44.15	-
595	Sumoylation	LRVHTGEKPFACPEC EEEECCCCCCCCCCH	46.94	-
595	Sumoylation	LRVHTGEKPFACPEC EEEECCCCCCCCCCH	46.94	-
618	Phosphorylation	KLTRHQRTHTGEKPY CCCCCCCCCCCCCCC	19.74	-
620	Phosphorylation	TRHQRTHTGEKPYHC CCCCCCCCCCCCCCC	46.56	-
723	Sumoylation	RRFHQSTKLIQHQRV HHHHHHHHHHHHCCC	49.17	-
723	Sumoylation	RRFHQSTKLIQHQRV HHHHHHHHHHHHCCC	49.17	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
27	S	Phosphorylation	Kinase	PAK4	O96013	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MZF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MZF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCND1_HUMAN	SCAND1	physical	10777584
ZNF24_HUMAN	ZNF24	physical	18472161
ZN202_HUMAN	ZNF202	physical	18472161
ZN174_HUMAN	ZNF174	physical	18472161

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MZF1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394, AND MASSSPECTROMETRY.	17081983 [Abstract]