| UniProt ID | GLI1_HUMAN | |
|---|---|---|
| UniProt AC | P08151 | |
| Protein Name | Zinc finger protein GLI1 | |
| Gene Name | GLI1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1106 | |
| Subcellular Localization | Cytoplasm . Nucleus . Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMe | |
| Protein Description | Acts as a transcriptional activator. [PubMed: 19706761] | |
| Protein Sequence | MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETNSCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLKSELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREGGPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLERRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGPPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGPPNMAVGNMSVLLRSLPGETEFLNSSA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 63 | Phosphorylation | ARETNSCTEGPLFSS CCCCCCCCCCCCCCC | 43.74 | - | |
| 69 | Phosphorylation | CTEGPLFSSPRSAVK CCCCCCCCCHHHHHH | 47.30 | 25159151 | |
| 70 | Phosphorylation | TEGPLFSSPRSAVKL CCCCCCCCHHHHHHH | 19.59 | 25627689 | |
| 84 | Phosphorylation | LTKKRALSISPLSDA HCCCCCCCCCCCCCC | 21.75 | 22617229 | |
| 86 | Phosphorylation | KKRALSISPLSDASL CCCCCCCCCCCCCCC | 19.20 | 20068231 | |
| 89 | Phosphorylation | ALSISPLSDASLDLQ CCCCCCCCCCCCCHH | 34.22 | 20068231 | |
| 92 | Phosphorylation | ISPLSDASLDLQTVI CCCCCCCCCCHHHHH | 27.66 | - | |
| 102 | Phosphorylation | LQTVIRTSPSSLVAF HHHHHCCCHHHHHHH | 16.97 | - | |
| 161 | Methylation | CGPHDSARGGMIPHP CCCCCCCCCCCCCCC | 46.26 | - | |
| 180 | Sumoylation | PFPTCQLKSELDMLV CCCCCHHHHHHHHHH | 18.92 | - | |
| 201 | Phosphorylation | PLEGDMSSPNSTGIQ CCCCCCCCCCCCCCC | 22.82 | - | |
| 204 | Phosphorylation | GDMSSPNSTGIQDPL CCCCCCCCCCCCCCH | 31.25 | - | |
| 205 | Phosphorylation | DMSSPNSTGIQDPLL CCCCCCCCCCCCCHH | 44.97 | - | |
| 243 | Phosphorylation | DCRWDGCSQEFDSQE CCCCCCCCCCCCCHH | 37.97 | - | |
| 296 | Phosphorylation | VVHMRRHTGEKPHKC EEEEHHCCCCCCCCC | 45.27 | 23532336 | |
| 304 | Phosphorylation | GEKPHKCTFEGCRKS CCCCCCCCCCCHHHH | 29.53 | - | |
| 319 | Ubiquitination | YSRLENLKTHLRSHT HHHHHHHHHHHHHHC | 45.54 | - | |
| 365 | Acetylation | NEKPYVCKLPGCTKR CCCCEEECCCCCCCC | 47.90 | 88883 | |
| 371 | Acetylation | CKLPGCTKRYTDPSS ECCCCCCCCCCCHHH | 47.70 | 88887 | |
| 373 | Phosphorylation | LPGCTKRYTDPSSLR CCCCCCCCCCHHHHH | 19.63 | 29496907 | |
| 374 | Phosphorylation | PGCTKRYTDPSSLRK CCCCCCCCCHHHHHH | 45.53 | 22817900 | |
| 377 | Phosphorylation | TKRYTDPSSLRKHVK CCCCCCHHHHHHHCE | 44.83 | 19060867 | |
| 378 | Phosphorylation | KRYTDPSSLRKHVKT CCCCCHHHHHHHCEE | 37.27 | 24719451 | |
| 408 | Phosphorylation | GPLPRAPSISTVEPK CCCCCCCCCCCCCCC | 28.34 | 28348404 | |
| 410 | Phosphorylation | LPRAPSISTVEPKRE CCCCCCCCCCCCCCH | 30.64 | 28348404 | |
| 411 | Phosphorylation | PRAPSISTVEPKRER CCCCCCCCCCCCCHH | 27.50 | 28348404 | |
| 518 | Acetylation | PIGTRGLKLPSLSHT CCCCCCCCCCCCCCC | 62.26 | 20081843 | |
| 521 | Phosphorylation | TRGLKLPSLSHTGTT CCCCCCCCCCCCCCC | 53.60 | - | |
| 527 | Phosphorylation | PSLSHTGTTVSRRVG CCCCCCCCCCCCCCC | 25.77 | - | |
| 538 | Phosphorylation | RRVGPPVSLERRSSS CCCCCCCCEEECCCC | 30.22 | 24719451 | |
| 544 | Phosphorylation | VSLERRSSSSSSISS CCEEECCCCCCCCCE | 32.21 | 28857561 | |
| 545 | Phosphorylation | SLERRSSSSSSISSA CEEECCCCCCCCCEE | 35.17 | - | |
| 560 | Phosphorylation | YTVSRRSSLASPFPP EEECCCHHCCCCCCC | 26.58 | 22817900 | |
| 597 | Methylation | RARYASARGGGTSPT HHHHHHHCCCCCCCC | 41.62 | - | |
| 602 | Phosphorylation | SARGGGTSPTAASSL HHCCCCCCCCHHHHC | 24.43 | 19664995 | |
| 622 | Phosphorylation | LPMPPWRSRAEYPGY CCCCCCCCCCCCCCC | 31.79 | - | |
| 640 | Phosphorylation | AGVTRRASDPAQAAD CCCCCCCCCHHHHCC | 42.17 | 28985074 | |
| 815 | Sumoylation | HYGQVQVKPEQGCPV ECEECEECCCCCCCC | 26.25 | - | |
| 934 | Phosphorylation | SPKFLGGSQVSPSRA CCCCCCCCCCCHHHC | 26.13 | 23312004 | |
| 937 | Phosphorylation | FLGGSQVSPSRAKAP CCCCCCCCHHHCCCC | 14.99 | 28985074 | |
| 939 | Phosphorylation | GGSQVSPSRAKAPVN CCCCCCHHHCCCCCC | 37.05 | - | |
| 948 | Phosphorylation | AKAPVNTYGPGFGPN CCCCCCCCCCCCCCC | 19.00 | 27642862 | |
| 968 | Phosphorylation | SGSYPTPSPCHENFV CCCCCCCCCCCCCEE | 42.51 | - | |
| 1003 | Sumoylation | PTCYGPLKVGGTNPS CCCCCCCEECCCCCC | 41.80 | 28112733 | |
| 1071 | Phosphorylation | SHDQRGSSGHTPPPS CCCCCCCCCCCCCCC | 37.10 | - | |
| 1074 | Phosphorylation | QRGSSGHTPPPSGPP CCCCCCCCCCCCCCC | 40.80 | - | |
| 1078 | Phosphorylation | SGHTPPPSGPPNMAV CCCCCCCCCCCCCCC | 70.48 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 84 | S | Phosphorylation | Kinase | RPS6KB1 | P23443 | GPS |
| 102 | S | Phosphorylation | Kinase | PRKAA2 | P54646 | GPS |
| 201 | S | Phosphorylation | Kinase | MAP3K3 | Q99759 | GPS |
| 204 | S | Phosphorylation | Kinase | MAP3K3 | Q99759 | GPS |
| 243 | S | Phosphorylation | Kinase | MAP3K3 | Q99759 | GPS |
| 243 | S | Phosphorylation | Kinase | PRKCI | P41743 | GPS |
| 304 | T | Phosphorylation | Kinase | PRKCI | P41743 | GPS |
| 374 | T | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| 374 | T | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 408 | S | Phosphorylation | Kinase | PRKAA2 | P54646 | GPS |
| 408 | S | Phosphorylation | Kinase | DYRK1A | Q13627 | PSP |
| 408 | S | Phosphorylation | Kinase | PRKAA1 | Q13131 | GPS |
| 544 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 544 | S | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| 560 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 560 | S | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| 640 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 640 | S | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| 968 | S | Phosphorylation | Kinase | MAP3K3 | Q99759 | GPS |
| 1074 | T | Phosphorylation | Kinase | PRKAA2 | P54646 | GPS |
| 1074 | T | Phosphorylation | Kinase | MAP3K3 | Q99759 | GPS |
| 1078 | S | Phosphorylation | Kinase | MAP3K3 | Q99759 | GPS |
| - | K | Ubiquitination | E3 ubiquitin ligase | ITCH | Q96J02 | PMID:20818436 |
| - | K | Ubiquitination | E3 ubiquitin ligase | SPOP | O43791 | PMID:22199232 |
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 518 | K | Acetylation |
| 20081843 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GLI1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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